A review on 3D printing in tissue engineering applications

Mani, Mohan Prasath; Sadia, Madeeha; Jaganathan, Saravana Kumar; Khudzari, Ahmad Zahran Md; Supriyanto, Eko; Saidin, Syafiqah; Ramakrishna, Seeram; Ismail, Ahmad Fauzi; Faudzi, Ahmad Athif Mohd

doi:10.1515/polyeng-2021-0059

Cited by 39 publications

(20 citation statements)

References 126 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This technology has widely emerged as an alternative manufacturing approach compared to conventional manufacturing techniques thanks to its ability to create complicated geometries for multimaterials with intricate features in decreased processing time for manufacturing. [177][178][179][180][181][182][183] 3D printing of SRPs utilizes the same commercial AM technologies to develop smart structures for different engineering applications. [184] However, 3D printers should be compatible with these smart materials or exhibit multimaterial characteristics for the cases where deformation mismatch within the structure causes functional or shape change.…”

Section: Am Techniquesmentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

Self Cite

View full text Add to dashboard Cite

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

show abstract

Section: Am Techniquesmentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

Self Cite

View full text Add to dashboard Cite

show abstract

“…When we associate the handling time of any AM procedure on average with the standard production method, AM procedure makes a 38 mm cube for about 1 hour while injection modeling can make less identical cubes per minute. Therefore, 3D printing is not suitable for use as a massproduction element of any product [141].…”

Section: Future Aspects and Challengesmentioning

confidence: 99%

3d Printing: A Review on the Transformation of Additive Manufacturing

KUMAR

SINGH

et al. 2022

Int J App Pharm

View full text Add to dashboard Cite

3D printing and nanotechnology have been two of the most important tools in the development of personalized medical treatments. More recently, their alliance has developed in an effort to create new, flexible, multidisciplinary, and/or medical and drug-wise products. Therefore, a comprehensive review of scientific studies, including 3D printing and nanomaterials on the development of new pharmaceutical methods and medical applications for the treatment and prevention of diseases, is presented here with the help of secondary research from most recent articles. 3D printing, also known as additive manufacturing, has held the power of building a new class of active nanocomposites. With the ability to print a layer of complex 3D objects by layer, additional production of nanomaterials can be used in new ways to significantly control architectural structures of all sizes. The high efficiency of embedded nanomaterials can further extend the power of nanocomposites to structures such as gradients in thermal conductivity, converted photonic emissions, and increased energy and reduced weight. According to the survey done by annual industry, around 50% of the market of 3d printing in the industrial sectors is credited to created prototypes by means of photopolymers. While, Formlabs, Stratasys, HP, Desktop Metal, Ultimaker, Carbon, EOS, Nanoscribe and Markforged are among the top additive manufacturers. This work is hereby an effort to focus on different techniques, merits and demerits, applications, recent advances, relation with nanotechnology along with future aspects.

show abstract

“…Medical implants fabricated by this additive manufacturing technique have better surface, mechanical properties, and biocompatibility, compared with traditional manufacturing methods. Consequently, 3Dprinted implants have been applied to major medical fields such as dentofacial, tracheobronchial, cardiovascular, orthopedics, skin wound healing, amongst others (18). Thus, there is a real need for a fast standardization of regulations for these medical products (17).…”

Section: Custom-made Device and D Printingmentioning

confidence: 99%

“…Scaffolds obtained by different 3D-printing technologies (e.g., extrusion-based, inkjet) as sparked much interest because their performance properties can be tuned according to a specific aim (18). Moreover, multifunctional scaffolds can be combined with drug delivery strategies with or without the use of external stimulus (e.g., magnetic, electric, phototermal) (21).…”

Section: Personalized D-printed Sca Oldsmentioning

confidence: 99%

The regulatory challenges of innovative customized combination products

2022

View full text Add to dashboard Cite

Background/aimsCombination products are therapeutic and/or diagnostic products that can combine drugs and medical devices and which increasing complexity has raised new regulatory framework challenges. To reach the market, a combination product must be classified based on the principal mode of action (PMOA). However, research and technological progress has been leading to the development of novel combination products with no clearly defined PMOA, emphasizing the lack of a systematization process, thus challenging the correct classification of these products. To illustrate the regulatory challenge, two case studies are discussed: innovative combination products with PMOA that can change due to an external stimulus, specifically custom-made 3D-printed scaffolds with incorporated medicinal substances.MethodsData was collected through computational search engines, regulatory agencies and equally relevant associations. The analysis of the data resulted on this state-of-the-art review, a description of the decision-making process by the regulatory authorities, and case studies analysis that culminated in the proposal of a decision-tree scheme.FindingsCurrent regulations do not fully address complex combination products namely personalized 3D-printed scaffolds. Two merged regulatory approaches are suggested along with the schematization of the rational assisted by a decision-tree tool.ConclusionCombination products have become increasingly sophisticated, which has furthered the need to develop multidisciplinary collaborations within the health sector to adapt to these innovative healthcare solutions as well as with regulators to overcome the challenges posed for their classification.

show abstract

A review on 3D printing in tissue engineering applications

Cited by 39 publications

References 126 publications

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

3d Printing: A Review on the Transformation of Additive Manufacturing

The regulatory challenges of innovative customized combination products

Contact Info

Product

Resources

About