Candida -associated denture stomatitis is a common fungal infection that affects removable denture wearers. Although Candida spp . are considered commensal fungal in the oral cavity, changes in local and/or systemic predisposing factors related to the host conditions may lead to pathogenic form and cause disease. The clinical manifestations are usually associated with the predisposing factors, changing from no symptoms to severe pain and diffi culty swallowing. The therapeutic strategies commonly adopted in the clinical practice are the use of topical and/or systemic antifungal, in addition to removing mechanically the plaque from denture surfaces and from underlying mucosa and give instructions about the correct oral hygiene to the patient. In this context, considering the high prevalence of this disease in the clinical practice, a review about the etiology, risk factors, clinical manifestations, and therapy management of these patients is of utmost importance.