A review of the relationship between acute toxicity (LC50) of γ-hexachlorocyclohexane (γ-HCH, Lindane) and total lipid content of different fish species

Dose and Time Determining, and Other Factors Influencing, Toxicity

“…As reviewed elsewhere (Hayes, 1959), various mammals and even fish are relatively resis tant to poisoning by DDT if they are fat rather than thin. The same result has been produced with dieldrin and lin dane under experimental conditions (Barnes and Heath, 1964;Geyer et al, 1993). Other factors may be involved, but certainly distribution of the insecticide to adipose tis sue tends to reduce the concentration of the insecticide at the site of action and thus protecting the organism.…”

“…For most of the substances tested a linear relationship was found between log(LD 50) and log(body weight). Geyer et al (1990Geyer et al ( , 1993 also found a linear rela tionship between log(LD 50) and log(total body fat content) for TCDD among more than 20 species and strains of mam mals. They argued that total body fat content was a surro gate measure of time because "fatter" animals intoxicated by TCDD lived longer than their leaner counterparts.…”

Polychlorinated biphenyl toxicokinetics and P4501A responses in anadromous Arctic charr during winter emaciation

“…Thus, the EROD data of the present study indicate a strongly enhanced toxicological potential of POPs that accumulate in species that undergo cycles of lipid accumulation and depletion. This is encapsulated in the ''survival of the fattest'' hypothesis of Lassiter and Hallam [39] and is supported by the findings of a negative relationship between acute toxicity of Lindane and body lipid content in different fish species (reviewed by Geyer et al [40]). …”

Comparison of Terbutryn Acute Toxicity to Danio rerio and Poecilia reticulata

“…(Mayer, Jr. and Ellersieck 1988). Median lethal concentration (LC50) values of organic chemicals in different fish species can often differ by factors of 10 or more and toxicity testing with only one fish species may be inadequate to classify chemicals belonging to these classes for their environmental impact (Geyer et al 1993;Gallo et al 1995). Danio rerio and Poecilia reticulata belong among fish species recommended by OECD Guidelines for Testing of Chemicals and to species frequently used in aquatic toxicology (Svobodová and Vykusová 1991;Gallo et al 1995;Kovrižnych and Urbančíková 2001;Hill et al 2005;Jurčíková et al 2007;Voslářová et al 2008;Mikula et al 2009;Plhalová et al 2009).…”