Comparison of Terbutryn Acute Toxicity to Danio rerio and Poecilia reticulata

Plhalová, Lucie; Mácová, Stanislava; Doleželová, Petra; Maršálek, Petr; Svobodová, Zdeňka; Pištěková, Vladimíra; Bedáňová, Iveta; Voslářová, Eva; Modrá, Helena

doi:10.2754/avb201079040593

Cited by 5 publications

(1 citation statement)

References 13 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The membrane not only forms a physical barrier, but may also bind metals, effectively reducing their passage to the embryos, as does the chorion in fish eggs (Beattie and Pascoe 1978). Plhalová et al (2010) reported that exposure of the embryonic stage of D. rerio to terbutryn gave a 144 hr LC50 of 8.04 ± 1.05 mg/L while for the juvenile stage the 96 hr LC50 was 5.71 ± 0.46 mg/L which suggested that juvenile stages were more sensitive to terbutryn than the embryonic stages. Green et al (1986) also showed that the embryos of Asellus aquaticus (L) were more resistant to the effects of cadmium than the early juveniles.…”

Section: Morphological Characteristicsmentioning

confidence: 99%

Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?

Mohammed¹

2013

New Insights Into Toxicity and Drug Testing

110

View full text Add to dashboard Cite

Additional information is available at the end of the chapter http://dx.doi.org/10.5772/55187 . Introduction . . The selection of a suitable test speciesToxicity tests are designed to determine the specific concentrations of chemicals that induce a measured effect on a target organism. However, the potency of any toxicant can be influenced by the characteristics of the chemical, as well as environmental temperature, ph, water chemistry, salinity and species life stage, sensitivity, pre-exposure specific factors. Environmental factors can either modify the toxicant itself or the immediate environment of an organism, increasing or decreasing the effects of the toxicants. Species specific factors can alter the organism/toxicant interaction by modifying the rate of uptake, distribution, elimination and detoxification pathways. Therefore when conducting toxicity tests, it is important to have controlled environmental conditions and select suitable test species to ensure reliable, relevant, reproducible, defensible and ecologically significant results. The selection of a suitable test species can be based on several criteria• the species should be widely available• they should be easily maintained under laboratory conditions and provide sufficient numbers of an appropriate size and age• the genetics, genetic composition and history of the organisms should be known• they should the most sensitive species in the environment.

show abstract

Section: Morphological Characteristicsmentioning

confidence: 99%

Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?

Mohammed¹

2013

New Insights Into Toxicity and Drug Testing

110

View full text Add to dashboard Cite

show abstract

Mutagenicity and Genotoxicity in Gill Erythrocyte Cells of Poecilia reticulata Exposed to a Glyphosate Formulation

Filho

Sousa

Silva

et al. 2013

Bull Environ Contam Toxicol

View full text Add to dashboard Cite

Poecilia reticulata were exposed to herbicide Roundup Transorb(®) for micronucleus test, nuclear abnormalities and comet assay. The exposure-concentrations were based on CL50-96 h following 0, 1.41, 2.83, 4.24 and 5.65 μL L(-1) for 24 h. Micronucleus and comets were significantly increased in the gill erythrocyte cells after herbicide exposure compared with the non-exposed group. Results showed a gradual increase in the number of damaged cells, indicating a concentration-dependent effect and that this herbicide was mutagenic and genotoxic to P. reticulata and this effect could be attributed to a combination of compounds contained in the formulation with the active ingredient glyphosate.

show abstract

Short-term exposure to low doses of rotenone induces developmental, biochemical, behavioral, and histological changes in fish

Melo

Oliveira

Grisólia

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

Rotenone, a natural compound derived from plants of the genera Derris and Lonchocarpus, is used worldwide as a pesticide and piscicide. This study aims to assess short-term toxicity of rotenone to early-life stages of the fish Danio rerio and Poecilia reticulata using a wide and integrative range of biomarkers (developmental, biochemical, behavioral, and histopathological). Moreover, the species sensitivity distribution (SSD) approach was used to compare rotenone acute toxicity to fish species. Toxicity tests were based on the OECD protocols, fish embryo toxicity test (for D. rerio embryos), and fish acute toxicity test (for P. reticulata juveniles). D. rerio embryos were used to estimate lethal concentrations and analyze embryonic and enzymatic alterations (activity of catalase, glutathione-S-transferase, and cholinesterase), while P. reticulata juveniles were used for the assessment of histological damage in the gills and liver. Rotenone induced significant mortality in zebrafish embryos with a 96-h lethal concentration 50% (LC50) = 12.2 μg/L. Rotenone was embryotoxic, affecting the development of D. rerio embryos, which showed cardiac edema; tail deformities; loss of equilibrium; and a general delay characterized by lack of tail detachment, delayed somite formation, yolk sac absorption, and lack of pigmentation. Biochemical biomarker inhibition was observed for concentrations ≥1 μg/L for CAT and glutathione-S-transferase (GST) and for cholinesterase (ChE) in concentration from 10 μg/L. Behavioral changes were observed for P. reticulata juveniles exposed to concentrations equal to or above 25 μg/L of rotenone; moreover, histological damage in the liver and gills of fish exposed to concentrations equal to or above 2.5 μg/L could be observed. A hazard concentration 5% (HC5) of 3.2 μg/L was estimated considering the acute toxicity data for different fish species (n = 49). Lethal and sublethal effects of rotenone raise a concern about its effects on nontarget fish species, especially because rotenone and its metabolite rotenolone are frequently reported in the microgram range in natural environments for several days after field applications. Rotenone should be used with caution. Given the high toxicity and wide range of sublethal effects here reported, further studies in a chronic exposure scenario are recommended.

show abstract

Comparison of Terbutryn Acute Toxicity to Danio rerio and Poecilia reticulata

Cited by 5 publications

References 13 publications

Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?

Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?

Mutagenicity and Genotoxicity in Gill Erythrocyte Cells of Poecilia reticulata Exposed to a Glyphosate Formulation

Short-term exposure to low doses of rotenone induces developmental, biochemical, behavioral, and histological changes in fish

Contact Info

Product

Resources

About