A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity

Nasiri-Toosi, Zahra; Dashti‐Khavidaki, Simin; Khalili, Hossein; Lessan‐Pezeshki, Mahboob

doi:10.1007/s00228-012-1452-x

Cited by 31 publications

(32 citation statements)

References 65 publications

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“…Pentoxifylline (PTX), a nonspecific phosphodiesterase inhibitor, was first considered for use in the treatment of peripheral vascular diseases. 8 PTX exerts several pharmacologic effects, including improvement in microcirculation, increase in erythrocyte deformability, reduction in blood viscosity, inhibition of platelet aggregation, endothelium-dependent vascular relaxation, immunomodulatory, anti-inflammatory, and antiproliferative effects. 8 In addition, it has been used as an antioxidant in order to heal damage in several tissues.…”

Section: Introductionmentioning

confidence: 99%

“…8 PTX exerts several pharmacologic effects, including improvement in microcirculation, increase in erythrocyte deformability, reduction in blood viscosity, inhibition of platelet aggregation, endothelium-dependent vascular relaxation, immunomodulatory, anti-inflammatory, and antiproliferative effects. 8 In addition, it has been used as an antioxidant in order to heal damage in several tissues. 9 Previous studies reported that PTX ameliorates the clinical markers of glomerular and tubulointerstitial injury in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative effects of pentoxifylline on NOS induced by diabetes in rat kidney

Sönmez

Dündar

2016

Renal Failure

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Objectives Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. The NO system has been implicated in the pathogenesis of DN. In this study, we aimed to evaluate the healing effect of pentoxifylline on NOS in STZ-induced diabetic rat's kidney. Material and methods In this study, 50 Wistar albino male rats were used. The rats were divided into five groups; Group C control; Group D only diabetes; Group D + PI and D + PII diabetes + pentoxifylline; Group P only pentoxifylline. Group DPI rats received just pentoxifylline from the beginning of the experiments. However, Group DPII rats received saline in the first month and 50 mg/kg/day of pentoxifylline for the following month. At the end of two months, NOS expressions in kidney tissue were assessed using qRT-PCR and immunohistochemistry analysis. Results At the end of the experiments, desquamation of the epithelial cells of the tubules, clear glycogen-filled distal tubules and increased number of apoptotic cells were seen in Group D. Diabetic rats' nNOS immunoreactivity had increased and eNOS and iNOS immunoreactivity had decreased; nNOS, iNOS and eNOS mRNA levels tended to decrease compared to the control group. PTX ameliorated eNOS, iNOS and nNOS protein levels and apoptotic cells, but did not affect mRNA levels. Conclusion In conclusion, PTX has a healing effect on this damage by affecting NOS expression. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of pentoxifylline on NOS induced by diabetes in rat kidney

Sönmez

Dündar

2016

Renal Failure

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“…In an experimental study, authors reported the beneficial effects of daily pentoxifylline treatment on recovery of erectile function in rats that underwent cavernosal nerve injury, thereby simulating postprostatectomy ED [34]. In urinary system, pentoxifylline have been used in different pathologic disorders such as nephrotoxicity, hemorrhagic cystitis, male infertility, testicular torsion, ischemic glans penis, and ureteral obstruction [35][36][37][38][39][40]. However, to our knowledge in the English literature, there is a only one experimental study, which evaluates the effect of pentoxifylline on penile cavernosal tissues in a rat model of ischemic priapism [41].…”

Section: Discussionmentioning

confidence: 97%

The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model

et al. 2014

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“…Hücrelerin canlılığı kültür ortamına tetrazolium tuzları eklenerek değerlendirildi. Pentoksifilinin 10 [1][2][3][4] . The growing appreciation of endothelium as a target of inflammation as well as a source of inflammatory mediators lead to ongoing research to shed light on the pathophysiology of several chronic disorders.…”

Section: Discussionmentioning

confidence: 99%

Effects of pentoxifylline on proliferation of human umbilical vein endothelial cells (HUVEC)

2016

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SUMMARYObjective: The aim of this study was to investigate the effect of pentoxifylline (PNX) with a pharmacological dose range on proliferation of human umblical venous endothelial cells (HUVEC). Method: The cells were maintained in M199 supplemented with 20% fetal bovine serum, penicillin, and streptomycin. The cultures were cultivated in an incubator at 37°C and with 5% CO2, until cell monolayers attained confluence which occurred after 7 days. The assays were performed in the exponential growth phase of the cells. The cell viability was assessed using the cleavage of tetrazolium salts added to the culture medium. Pentoxifylline with concentrations of 10 -4 M, 10-5M, 10 -6 M and 10 -7 M were used for the proliferation assay in which cells were incubated for 24, 48, and 72-hours with these drugs. The experiments were conducted in six replicates. Results: Only the 10 -4 M dose of PNX at 72 h significantly reduced the viability of HUVEC (p<0.05) and except this, there was no cytotoxic effect of PTX on HUVEC in a dose-and time-dependent manner (p>0.05). Conclusions: Overall, PTX with a pharmacological dose range has no cytotoxic effect on HUVEC. We think that this is also in accordance with the findings of several studies performed in animal models and clinical settings, indicating positive effects of PTX on tissues in normal and ischemic conditions. Keywords: Pentoxifylline, proliferation, human umbilical venous endothelial cells ÖZET Amaç: Bu çalışmanın amacı farmokolojik doz aralığında uygulanan pentoksifilinin insan umblikal ven endotel hücrelerinin (HUVEC) proliferasyonu üzerine etkisini araştırmaktır. Yöntem: Hücreler içerisine %20 fetal bovine serum, penisilin ve streptomisin eklenen M199 besiyeri içinde, %5 CO2 içeren 37 C 'lik inkübatörde kültüre edildi. Deneyler hücreler gelişim fazında iken gerçekleştirildi. Hücrelerin canlılığı kültür ortamına tetrazolium tuzları eklenerek değerlendirildi. Pentoksifilinin 10 -4

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A review of the potential protective effects of pentoxifylline against drug-induced nephrotoxicity

Cited by 31 publications

References 65 publications

Ameliorative effects of pentoxifylline on NOS induced by diabetes in rat kidney

Ameliorative effects of pentoxifylline on NOS induced by diabetes in rat kidney

The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model

Effects of pentoxifylline on proliferation of human umbilical vein endothelial cells (HUVEC)

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