The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model

Erdemır, Fikret; Fırat, Fatih; Markoç, Fatma; Atılgan, Doğan; Parlaktaş, Bekir Süha; Kuyucu, Yunus Emre; Gençten, Yusuf

doi:10.1007/s11255-014-0769-z

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…Sustained NO releasing compounds have also been shown to normalize activated eNOS and other biochemical elements of erection signaling in mouse models of priapism (37). In a rat model of ischemic priapism, treatment with pentoxyfylline, a non-selective PDE inhibitor, reduced collagen density in the corpus cavernosum, possibly through mechanisms relating to inhibition of TGF-β (58). Sildenafil may provide a vasculoprotective effect through increased expression of eNOS and inhibition of NADPH oxidase, the enzyme responsible for the production of the free radical superoxide (39).…”

Section: Epidemiologymentioning

confidence: 99%

Advances in the understanding of priapism

Hudnall

Reed‐Maldonado

Lue

2017

Transl. Androl. Urol.

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Priapism, a persistent penile erection lasting longer than 4 hours and unrelated to sexual activity, is one of the most common emergencies treated by urologists. Priapism can be categorized as ischemic, recurrent ischemic (stuttering), and non-ischemic. Advances in understanding the pathophysiology of various types of priapism have led to targeted management strategies. This review aims to provide an up-to-date picture of the pathophysiology and management of priapism. A search of Medline and PubMed for relevant publications using the term “priapism” was performed. In addition to the “classical” articles, emphasis was placed on publications from January 2013 to September 2016 to evaluate the most recent literature available. Though advances in both basic and clinical research continue and effective treatment options are available, methods for the prevention of priapism continue to be elusive.

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Section: Epidemiologymentioning

confidence: 99%

Advances in the understanding of priapism

Hudnall

Reed‐Maldonado

Lue

2017

Transl. Androl. Urol.

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“…This agent had facilitated recovery of erections in a rat model of erectile dysfunction post prostatectomy [118]. In a recent study, pentoxifylline was able to reduce collagen density in an ischemic-induced priapism rat model [119]. The potential benefits of an agent with such an effect are great and this agent requires further studies.…”

Section: Priapism Treatmentmentioning

confidence: 99%

Molecular Pathophysiology of Priapism: Emerging Targets

Anele¹,

Morrison²,

Burnett³

2015

CDT

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Priapism is an erectile disorder involving uncontrolled, prolonged penile erection without sexual purpose, which can lead to erectile dysfunction. Ischemic priapism, the most common of the variants, occurs with high prevalence in patients with sickle cell disease. Despite the potentially devastating complications of this condition, management of recurrent priapism episodes historically has commonly involved reactive treatments rather than preventative strategies. Recently, increasing elucidation of the complex molecular mechanisms underlying this disorder, principally involving dysregulation of nitric oxide signaling, has allowed for greater insights and exploration into potential therapeutic targets. In this review, we discuss the multiple molecular regulatory pathways implicated in the pathophysiology of priapism. We also identify the roles and mechanisms of molecular effectors in providing the basis for potential future therapies.

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“…[12] Conversely, Costa et al found significantly more collagen and less CCSMC in the corpus cavernosum of IP patients compared to those of normal males. Similarly, others demonstrated significant lower CCSMC/collagen in rats after IP [13,14]. Damaged endothelial continuity could be also found [14].…”

Section: Discussionmentioning

confidence: 83%

“…Similarly, others demonstrated significant lower CCSMC/collagen in rats after IP [13,14]. Damaged endothelial continuity could be also found [14].…”

Section: Discussionmentioning

confidence: 83%

Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism

Gao

et al. 2017

J Cellular Molecular Medi

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Penile fibrosis caused by ischemic priapism (IP) adversely affects patients’ erectile function. We explored the role of lysyl oxidase (LOX) in rat and human penes after ischemic priapism (IP) to verify the effects of anti‐LOX in relieving penile fibrosis and preventing erectile dysfunction caused by IP in rats. Seventy‐two rats were randomly divided into six groups: control group, control + β‐aminopropionitrile (BAPN) group, 9 hrs group, 9 hrs + BAPN group, 24 hrs group, and 24 hrs + BAPN group. β‐aminopropionitrile (BAPN), a specific inhibitor of LOX, was administered in the drinking water. At 1 week and 4 weeks, half of the rats in each group were randomly selected for the experiment. Compared to the control group, the erectile function of IP rats was significantly decreased while the expression of LOX in the corpus cavernosum was significantly up‐regulated in both 9 and 24 hrs group. Proliferated fibroblasts, decreased corpus cavernosum smooth muscle cells/collagen ratios, destroyed endothelial continuity, deposited abnormal collagen and disorganized fibers were observed in IP rats. The relative content of collage I and III was not obviously different among the groups. β‐aminopropionitrile (BAPN) could effectively improve the structure and erectile function of the penis, and enhance recovery. The data in this study suggests that LOX may play an important role in the fibrosis of corpus cavernosum after IP and anti‐LOX may be a novel target for patients suffering with IP.

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The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model

Abstract: The results of the present study showed that ischemic priapism caused damage in the penile tissues of rats, and treatment with pentoxifylline reduced the harmful effects of ischemic priapism.

Cited by 10 publications

References 41 publications

Advances in the understanding of priapism

Advances in the understanding of priapism

Molecular Pathophysiology of Priapism: Emerging Targets

Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism

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