A review of the effect of various ions on the properties and the clinical applications of novel bioactive glasses in medicine and dentistry

Ali, Saqib; Farooq, Imran; Iqbal, Kefi

doi:10.1016/j.sdentj.2013.12.001

Cited by 44 publications

(35 citation statements)

References 37 publications

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“…In medicine, it is commonly being used as a bone graft to promote osteogenesis whereas, in dentistry, it is frequently being used in dentifrices to treat dentin hypersensitivity (DH) and as a coating material of dental implants 33,34 . Few of the common uses ofBGs are explained here.…”

Section: Bio-dental Applications Of Bioactive Glass (Bg)mentioning

confidence: 99%

Bioactive Glasses and their Applications in Dentistry

Khalid¹,

Khurshid²,

Zafar³

et al. 2017

J Pak Dent Assoc

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ABSTRACT:Biomaterials have always been used for the replacement, repair and regeneration of dental hard tissues. As the research continues, there is a significant development in the field of dental materials in terms of either developing new materials or improving the performance of the existing materials. Contrary to the development of bioinert materials, the recent hard tissue research has witnessed the development and subsequent applications of bioactive materials, a hallmark of which is the development of bioactive glass. Originally discovered in 1969, bioactive glasses have provided a reliable alternative to inert implant materials by virtue of their ability to form a stable bond with host tissues and induce subsequent remineralization especially of the dental hard tissues. This article comprehensively reviews the early development, chronological applications and mechanism of action of bioactive glasses in general and briefly encompasses their applications in clinical dentistry.

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Section: Bio-dental Applications Of Bioactive Glass (Bg)mentioning

confidence: 99%

Bioactive Glasses and their Applications in Dentistry

Khalid¹,

Khurshid²,

Zafar³

et al. 2017

J Pak Dent Assoc

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“…Similarly, in primate models, bioactive glass filled bony defects by stimulating osteoproduction. Felipe et al reported that bioactive glass particles were able to treat periodontal defects and triggered the development of mineralized bone in dogs [141,142].…”

Section: Tricalcium Phosphate/hydroxyapatite Biphasic Ceramics (Bcp)mentioning

confidence: 99%

Bioceramic Scaffolds

Amin¹,

Ewais²

2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Millions of peoples in the world suffer from their bone damage tissues by disease or trauma. Every day, thousands of surgical procedures are performed to replace or repair these tissues. The availability of these tissues is a big problem, and their costs are expensive. The repair of these defects has become a major clinical and socioeconomic need with the increase of aging population and social development. The emerge of tissue engineering (TE) is considered as a glimmer of hope to contribute in solving this problem. It aims at the regeneration of damaged tissues with restoring and maintaining the function of human bone tissues using the combination of cell biology, materials science, and engineering principles. In this chapter, the current state of the tissue engineering in particular bioceramic scaffolds was discussed. Concept of tissue engineering was explored. Bioceramic scaffold materials, their processing techniques, challenges taken into consideration the design of the scaffolds, and their in-vitro and in-vivo studies were highlighted. The scaffolds with extra-functionalities such as drug release ability and clinical applications were mentioned.

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“…It was previously reported that not only does Bioglass® bind to bone but it also facilitates the regeneration of bone. Initially the bone substitute was implanted into humans as a replacement for the ossicles of the middle ear and was subsequently used as a material to repair bone defects eventually including those caused by periodontitis as well (Ali et al, 2014). There are four main methods by which genes involved with osteoblastic proliferation, differentiation, and cell to cell adhesion are upregulated namely: surface chemistry, topography, rate and type of dissolution ions and shear stress at the interface.…”

Section: Class B Bioactive Glassesmentioning

confidence: 99%

“…The original 45S5 Bioglass® contained 45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O55, however, subsequently more research has been conducted into incorporating various therapeutic ions, drugs and growth factors into the glass structure. Table 2 outlines a variety of products that have been incorporated into the glass structure to provide a beneficial effect (Ali et al, 2012;Ali et al, 2014).…”

Section: Therapeutic Ions Drugs and Growth Factorsmentioning

confidence: 99%

Bioactive Glasses in the Management of Dentine Hypersensitivity: A Review

Samueli¹,

Rg²,

Gillam³

2017

Dent Health Curr Res

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Dentine Hypersensitivity is a common clinical condition, albeit of a low severity, and various in vitro and in vivo studies have been performed to test various approaches in managing the condition. This review investigates the use of bioactive glasses and their efficacy in treating Dentine Hypersensitivity.Significant progress was observed in the introduction of bioactive glasses in previous toothpaste formulations due to its ability to produce a Hydroxyapatite-like layer. Nevertheless, the results of the present review would suggest that a higher quality evidence was required to sufficiently support the use and effectiveness of bioactive glasses in treating Dentine Hypersensitivity. This observation is particularly pertinent in the absence of evidence relating to the effect of abrasivity of the glasses as well as the ability of strontium incorporation into the glasses. And the exact loading of the glass into dentifrice formulations. Overall, in vitro studies do appear to demonstrate that bioactive glass formulations may be an effective material to occlude dentine tubules which may in turn, reduce the fluid flow within the dentinal tubules and subsequently help manage Dentine Hypersensitivity.

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A review of the effect of various ions on the properties and the clinical applications of novel bioactive glasses in medicine and dentistry

Cited by 44 publications

References 37 publications

Bioactive Glasses and their Applications in Dentistry

Bioactive Glasses and their Applications in Dentistry

Bioceramic Scaffolds

Bioactive Glasses in the Management of Dentine Hypersensitivity: A Review

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