A review of the clinical implications of bisphosphonates in dentistry

Borromeo, Gelsomina L; Tsao, Claudine; Darby, Ivan; Ebeling, Peter R.

doi:10.1111/j.1834-7819.2010.01283.x

Cited by 74 publications

(77 citation statements)

References 61 publications

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“…Indeed during bone healing and remodelling, an adequate vascular system is essential, with blood vessels in the canaliculi, Volkmans canals and the Haversian systems playing key roles. It is these vessels that involute, leaving bone dead and avascular in BRONJ [97,123]. Ziebart et al [122], highlighted the importance of differentiating between angiogenesis and vasculogenesis.…”

Section: Angiogenesis and Vasculogenesismentioning

confidence: 99%

“Bisphosphonates: Possible Modes of Action and Implications for Dental Implant Treatment. A Review of the Literature”

Ballantyne¹

2016

J Gen Pract

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Section: Angiogenesis and Vasculogenesismentioning

confidence: 99%

“Bisphosphonates: Possible Modes of Action and Implications for Dental Implant Treatment. A Review of the Literature”

Ballantyne¹

2016

J Gen Pract

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“…Lesions in patients who have not fulfilled the above four characteristics should be excluded from the diagnosis of BRONJ [31,[38][39][40][41][42].…”

Section: Clinical Presentationmentioning

confidence: 99%

Bisphosphonate Related Osteonecrosis of the Jaw: An Update

Kumar¹,

Sinha²

2013

J. Maxillofac. Oral Surg.

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Objectives The aim of this paper is to summarize different diagnostic criteria as well as probable aetiopathogenesis of bisphosphonates related osteonecrosis of the jaw. Materials and MethodsThe electronic search of peerreviewed journals were performed in MEDLINE (PubMed) database in order to find the relevant articles on bisphosphonates related osteonecrosis of the jaw (BP-related ONJ). The search was restricted to English language articles, published from January 2002 to May 2013. On the basis of these articles, probable aetiopathogenesis and different diagnostic criteria of BP-related ONJ were summarized. Results BP-related ONJ is related to the development of avascular necrosis or dead jaw bones. In recent literature many given hypotheses show the aetiopathogenesis and diagnosis of BP-related ONJ which are interlinked and have multifactorial nature. Their diagnosis revolves around four main diagnostic criteria that differentiate it from other conditions which can delay bone healing. Conclusions Factors like potency of bisphosphonates, biology of jaw bone, antiangiogenic property of bisphosphonates and soft tissue toxicity in combination with present infection, other drugs, pre-existing pathologies, compromised immune response and dentoalveolar trauma may lead to development of BP-related ONJ.

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“…1 BP paling sering digunakan untuk pengobatan osteoporosis, penyakit Paget's, metastasis keganasan pada tulang dan kondisi-kondisi lain yang menyebabkan kerapuhan tulang. 2,3 Walaupun sudah banyak laporan adanya efek samping penggunaan BP yang terkait dengan bidang kedokteran gigi, namun penggunaan obat ini untuk kepentingan perawatan di dalam rongga mulut juga sedang diteliti.…”

Section: Pendahuluanunclassified

“…1 Osteonekrosis rahang (ONJ) dijumpai pada pasien yang mengkonsumsi BP untuk terapi yang berkaitan dengan berbagai penyakit pada tulang. Insidensinya 0,8%-12% yang mendapatkan terapi BP secara intravena dan 0,01%-0,04% secara peroral.…”

Section: American Society For Bone and Mineral Researchunclassified

Bisphosphonate: Brief Review of Its Development for Usage in Dentistry

Utari

2013

J Dent Indones

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Bisphosphonate (BP) is a class of drug that prevent the loss of bone mass. It inhibits the resorption of bone by encouraging osteoclast to undergo apoptosis. Considering that oral diseases and dental procedures may lead to teeth instability whereas alveolar bone is the main tooth supporting tissue, forceful indication of this drug is for preventing and minimizing bone resorption following oral surgery and relapse movement in orthodontic treatment. Clinical use of BP in dentistry is limited by risk of osteonecrosis of the jaw (ONJ) and of its systemic effects such as an increase of the bone mineral density in another bone area. Topical application with local effect would seem the choice of administration route for usage in dentistry. Until recently, no clinical usage of topical BP has been studied, however some experimental laboratory studies proved that this drug would be beneficial in a wide scope of dental treatments. ABSTRAKBisfosfonat: tinjauan singkat pengembangan penggunaanya di bidang kedokteran gigi. Obat ini menghambat resorpsi tulang dengan memicu osteoklas mengalami apoptosis. Bisfosfonat (BP) memiliki potensi manfaat besar dalam dunia kedokteran gigi mengingat bahwa baik penyakit maupun prosedur perawatan gigi dapat menyebabkan ketidakstabilan gigi dan diketahui bahwa tulang alveolar merupakan jaringan pendukung utama gigi. Indikasi kuat dari obat ini adalah untuk mencegah dan meminimalkan resorpsi tulang setelah operasi bedah mulut dan gerakan relaps setelah perawatan ortodontik. Penggunaan secara klinis BP dalam kedokteran gigi dibatasi oleh risiko osteonekrosis rahang (ONJ) dan efek sistemik seperti peningkatan kepadatan mineral tulang di daerah lain. Aplikasi topikal dengan efek lokal tampak sebagai pilihan solusi untuk risiko di atas. Penelitian terbaru dari BP topikal belum sampai pada penggunaan klinis, tetapi dari beberapa penelitian pada hewan coba telah memberikan bukti bahwa obat ini akan bermanfaat dalam lingkup yang luas pada perawatan kedokteran gigi.Key words: alveolar bone, bisphosphonate, topical administration PENDAHULUAN Bisfosfonat (BP) adalah kelompok obat yang memiliki kemampuan mencegah hilangnya massa tulang dengan mekanisme penghambatan osteoklas sehingga menekan turnover tulang.1 BP paling sering digunakan untuk pengobatan osteoporosis, penyakit Paget's, metastasis keganasan pada tulang dan kondisi-kondisi lain yang menyebabkan kerapuhan tulang. 2,3Walaupun sudah banyak laporan adanya efek samping penggunaan BP yang terkait dengan bidang kedokteran gigi, namun penggunaan obat ini untuk kepentingan perawatan di dalam rongga mulut juga sedang diteliti. Dalam dunia kedokteran gigi, penggunaan BP kemungkinan dapat memberikan harapan dalam upaya menstabilkan gigi dalam tulang alveolar. Masalah stabilitas gigi selalu menjadi perhatian di semua cabang ilmu kedokteran gigi. Ketidakstabilan gigi dapat terjadi akibat penyakit maupun tindakan yang dilakukan oleh dokter gigi. Salah satu faktor penentu utama stabilitas gigi adalah keutuhan tulang alveolar. BP membuka harapan untu...

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A review of the clinical implications of bisphosphonates in dentistry

Cited by 74 publications

References 61 publications

“Bisphosphonates: Possible Modes of Action and Implications for Dental Implant Treatment. A Review of the Literature”

“Bisphosphonates: Possible Modes of Action and Implications for Dental Implant Treatment. A Review of the Literature”

Bisphosphonate Related Osteonecrosis of the Jaw: An Update

Bisphosphonate: Brief Review of Its Development for Usage in Dentistry

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