Introduction Orthodontic relapse occurs after orthodontic treatment and shifting of teeth to unfavorable positions. Bisphosphonates’ effects on bone resorption and relapse prevention have been extensively investigated. However, topical administration, which results in local effect, is still a problem. Objective This study aimed to investigate the effect of risedronate with gelatin hydrogel as a carrier to prevent relapse movement by inhibiting osteoclast activity. Methods Lower incisors of 75 guinea pigs were moved distally using an orthodontic appliance until ±3 mm length. Gelatin hydrogel was fabricated to obtain a semisolid controlled release of 250 (Bis-CR250) and 500 mmol/L risedronate (Bis-CR500) and then applied intrasulcularly into the mesial subperiosteal area of 50 guinea pigs (25 in each group) every 3 days; the rest were the control (Bis-CR000). After 14 days of stabilization, the apparatus was removed. The distance decrease between incisors and the osteoclast number with TRAP staining at 0, 3, 7, 14, and 21 days were measured. ANOVA was used to determine the differences among the different time and experimental groups. Results Both treatments showed significantly less relapse movement compared to the control (p < 0.05) at 14 and 21 days. Bis-CR500 more effectively inhibited the relapse movement than Bis-CR250 on day 21, indicating a dose dependency in the inhibition. Both treatments showed less osteoclast numbers than control (p < 0.05). Conclusion Controlled release of bisphosphonate risedronate with a topically administered gelatin hydrogel has shown to be effective in decreasing the tooth relapse movement and osteoclast activity.
Introduction: The prevalence of malocclusion in Indonesia is still very high, which is about 80% of the population and is one of the major dental and oral health problems. Based on the research result by the Health Research and Development Department, Ministry of Health Republic Indonesia, the highest malocclusion prevalence in children aged 12-15 years is 15.6%. Problems in adolescents aged 13-15 oral cavity, such as disruption of tooth eruption, can cause malocclusion, related function, aesthetics, and quality of life. Objective: To assess orthodontic treatment need in adolescents aged 13-15 years in Muhammadiyah 3 Junior High School of Yogyakarta using Orthodontic Treatment Needs Indicators, the description of malocclusion classification and their correlation. Method: This research is an analytical observational study with cross-sectional design. Samples are 100 students aged 13-15 years in Muhammadiyah 3 Junior High School of Yogyakarta. Each sample fills out an IKPO questionnaire to assess the need for orthodontic treatment needs, examination, and intraoral photographs were taken to determine the malocclusion classification. Results: The results showed 61% of subjects required orthodontic treatment, and 63% had Class I malocclusion, 28% had Class II malocclusion, and 9% had Class III malocclusions. There was a correlation between the questionnaire of orthodontic treatment needs on age with a significant value, 0.037 (p<0.05). Conclusion: More than 50% of adolescents aged 13-15 years at Muhammadiyah 3 Junior High School of Yogyakarta need orthodontic treatment with the highest malocclusions is Class I Angle malocclusion, and there is a correlation between age and orthodontic treatment needs.
Background: The increasing of osteoblast activities during bone formation will be accompanied with the increasing expression of alkaline phosphatase enzyme (ALP). ALP can be obtained from clear fluid excreted by gingival crevicular fluid (GCF
ABSTRAKMaloklusi Angle kelas II divisi 2 dengan karakteristik retroklinasi insisivus sentral, proklinasi insisivus lateral disertai deep overbite yang parah menyebabkan gangguan estetik bagi pasien. pencabutan gigi premolar atas umumnya dilakukan untuk memperbaiki maloklusi pada pasien dewasa. Laporan kasus ini bertujuan memaparkan perawatan ortodontik dengan diagnosis maloklusi Angle Klas II Divisi 2 dengan tujuan memperbaiki crowding dan deep over bite sehingga diperoleh estetika yang baik. Kasus 1, pasien perempuan berusia 19 tahun dengan overjet 0,5 mm, deepbite (overbite 7,8 mm), dan ANB 10° (SNA 92°, SNB 82°). Kasus 2, pasien laki laki berusia 18 tahun dengan overjet 0,5 mm, deepbite (overbite 9 mm), dan ANB 10,5° (SNA 87,5°, SNB 77°). Diagnosis kedua kasus tersebut maloklusi Angle kelas II divisi 2 dengan insisivus sentralis rahang atas palatoversi, insisivus lateralis labio versi disertai crowding gigi anterior dan bentuk lengkung trapezoid. Pasien dilakukan perawatan ortodontik menggunakan alat cekat Straight Wire System dengan pencabutan premolar pertama kanan dan kiri rahang atas. Perawatan diawali dengan melakukan koreksi inklinasi gigi insisivus sentral atas sehingga memungkinkan pemasangan braket pada rahang bawah. Dilanjutkan distalisasi gigi kaninus, kemudian retraksi sekaligus intrusi gigi anterior rahang atas menggunakan wire dengan U-loop. Perawatan klas II divisi 2 dengan pencabutan premolar pertama rahang atas kanan dan kiri dapat memperbaiki relasi gigi anterior. Deep overbite dan crowding gigi anterior pada kedua pasien tersebut dapat dikoreksi sehingga diperoleh estetika wajah yang jauh lebih baik. PENDAHULUANKarakteristik maloklusi kelas II divisi 2 sering kali disertai dengan deepbite yang parah, insisivus sentral maksila dan mandibula inklinasi kearah lingual, dan insisivus lateral maksila inklinasi ke arah labial.1 Maloklusi ini diakui memiliki kombinasi yang unik dari overbite, gigi seri retroklinasi, dan adanya perbedaan sagital. Fenotipe kelas II divisi 2 yang sangat parah, ditandai dengan penutupan gigi seri rahang bawah pada saat oklusi, dalam bahasa Jerman disebut 'Deckbiss' yang artinya menutupgigitan ('cover-bite'). Cover-bite atau Deckbiss dide nisikan sebagai ekspresi yang parah dari maloklusi Angle kelas II divisi 2, ditandai penutupan
Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement Materials and methods: The research design is experimental with time series. The lower incisors of 75 guinea pigs are distally moved using open coil spring. The guinea pigs were divided into three groups: without risedronate (group A; n = 25); given 250 µmol/L of risedronate hydrogel (group B; n = 25), and given 500 µmol/L of risedronate hydrogel (group C; n = 25). Risedronate were applied intrasulcularly in the mesial part of the gingival sulcus every 3 days. After 14 days of stabilization, the open coil spring was removed (bisphosphonate administration was continued). The relapsed teeth and ALP levels on days 0, 3, 7, 14, and 21 were measured. The osteoclast/osteoblast ratio was measured by hematoxylin and eosin staining. ANOVA test was used to determine the difference in the three groups and their interactions with concentration and time. Results: There was a significant difference in osteoclast/osteoblast ratio on day 3 (p = 0.019, p
Health services are currently required to do services by following implementation standard precaution that has been established, to create good quality services. Infection that needs to be an alert for the dental health care professional is the Human Immunodeficiency Virus. Implementation standard precautions need to be applied to a patient with HIV-AIDS or non-HIV-AIDS infection on risky dental treatments. Qualitative research was chosen in this case studies. The approach in this study is a content analysis which means analyzing the contents of interview results, direct observation, and document observation. Direct observation of PLHIV patients was done perfectly: hand hygiene 46.7%, PPE 95.5%, safe injection 100%, waste and sharp object management 75%, patient care equipment 80%, linen management 100%, environmental management 53.3%, employee health protection 0%, and cough ethics 0%. Results of documents observations related to hand hygiene, patient care equipment, and environmental management are well listed; related to PPE, management of waste and sharp objects, and employee health protection are listed but not yet complete; and related to safe injections, linen management, and cough ethics are not listed on document in X Public Health Center Yogyakarta. Implementation standard precaution overall is quite good and still needs to be improved, in order to prevent and control infections, especially HIV-AIDS infections in X Public Health Center Yogyakarta.Pelayanan kesehatan saat ini dituntut melakukan pelayanan sesuai penerapan kewaspadaan standar yang ditetapkan, demi terciptanya pelayanan yang bermutu. Salah satu infeksi virus yang perlu menjadi kewaspadaan para tenaga medis gigi adalah Human Immunodefficiency Virus. Penerapan kewaspadaan standar perlu diterapkan pada pasien dengan HIV-AIDS atau tanpa HIV-AIDS pada perawatan gigi berisiko. Penelitian kualitatif dan jenis penelitian adalah studi kasus. Pendekatan dalam penelitian ini adalah analisis isi. Menganalisis isi dari hasil wawancara, checklist observasi langsung, dan observasi dokumen. Hasil observasi langsung pada pasien ODHA yang dilakukan dengan sempurna: kebersihan tangan 46.7%, APD 95.5%, penyuntikan yang aman 100%, manajemen limbah dan benda tajam 75%, peralatan perawatan pasien 80%, penanganan linen 100%, manajemen lingkungan 53.3%, perlindungan kesehatan karyawan 0%, dan etika batuk 0%. Hasil observasi dokumen terkait kebersihan tangan, peralatan perawatan pasien, dan manajemen lingkungan sudah tercantum dengan baik; terkait APD, manajemen limbah dan benda tajam, dan perlindungan kesehatan karyawan sudah tercantum tetapi belum lengkap; dan terkait penyuntikan yang aman, penanganan linen, dan etika batuk tidak tercantum dalam dokumen Puskesmas X Yogyakarta. Penerapan kewaspadaan standar secara keseluruhan cukup baik dan masih perlu ditingkatkan lagi untuk mencegah dan mengendalikan infeksi terutama infeksi HIV-AIDS di Puskesmas X Yogyakarta.
Introduction: Relapse is one of the undesirable effects of orthodontic treatment. Prevention of relapse has been carried out with the use of retainer devices. Several studies also have been carried out to prevent relapse with pharmacological agents such as bisphosphonates. One of the strongest bisphosphonates is risedronate. Systemic use of bisphosphonates can cause bisphosphonate-related necrosis of the jaw (BRONJ). Systemic effects can be minimised by topical preparations locally, where the virgin coconut oil (VCO) emulgel is one of the topical preparations which controls the release of drugs. This study aims to analyse the release profile of risedronate emulgel as a material to inhibit relapse movement. Methods: This research was conducted in an experimental laboratory. Group 1 was emulgel without bisphosphonate risedronate with virgin coconut oil (VCO), Group 2 was VCO emulgel with bisphosphonates risedronate, and Group 3 was a pure bisphosphonate risedronate solution. Each group weighing 100 mg was placed in 10 ml PBS, and the release test was conducted with UV/VIS Spectrophotometer wavelength λ 262 nm at intervals of 1, 2, 4, 8, 24, 48, and 96 hours with three replications at each group. Results: Grup 2 yielded a controlled drug release of risedronate until 96 hours, while a pure solution of risedronate resulted in an uncontrolled drug release of risedronate, which was released entirely in 4 hours. Conclusion: Risedronate emulgel with VCO had a controlled drug release compared to pure bisphosphonate solution to potentially be applied topically to inhibit relapse movement.
Objective: This case report is to describe the management of bilateral impacted canine due to the persistence of deciduous teeth with surgical procedures and retraction with orthodontic tools. Methods: Orthodontic treatment used a Straight Wire system with a 0.22 bracket slot. It began with the use of Niti 0.14 for the correction of anterior teeth crowding. Teeth 53 and 63 extraction were performed and continued with Niti 0.18 wire to correct crowding and obtain sufficient eruption spaces for teeth 13 and 23. The surgery used an open window procedure with a full-thickness triangular flap to open the canine crown, bracket placement, and canine retraction using an elastomeric chain. Results: Within five months, the crowding was corrected, and enough space was obtained for the canine eruption, and within three months, the canine had reached the occlusal plane perfectly. Conclusion: Bilateral impacted canines can be treated with a combination of surgical procedure and retraction with orthodontic treatment to achieve optimum occlusion and aesthetic function.
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