A review of the berberine natural polysaccharide nanostructures as potential anticancer and antibacterial agents

Khan, Suliman; Hussain, Arif; Attar, Farideh; Bloukh, Samir Haj; Edis, Zehra; Sharifi, Majid; Balali, Ebrahim; Nemati, Fahime; Derakhshankhah, Hossein; Zeinabad, Hojjat Alizadeh; Nabi, Faisal; Khan, Rizwan Hasan; Xiao, Huang; Lin, Yn-Hwang; Hua, Liang; Hagen, Timo L.M. ten; Falahati, Mojtaba

doi:10.1016/j.biopha.2021.112531

Cited by 28 publications

(16 citation statements)

References 205 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The bioactivities of berberine, including anticancer activity, have been a research hotspot. Therefore, many review papers on berberine have been published in the literature from different points of view [ 20 , 21 , 22 , 23 ]. This paper is an updated review on anticancer effects and the mechanisms of berberine, and it highlights anticancer activity through targeting antibacterial action, including regulating gut microbiota and inhibiting intratumoral microbes.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

View full text Add to dashboard Cite

Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.

show abstract

Section: Introductionmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…Furthermore, the current in vitro results revealed that BBR-BSA NPs greatly enhanced the antioxidant properties of its entrapped BBR against NO · , H 2 O 2 , O 2 − , OH − , DPPH, TBARS, and potassium ferricyanide/ferric chloride, and ammonium molybdate radicals compared to BBR. BBR-loaded polymeric nanostructures have been used to improve the physicochemical characteristics (solubility, dissolution rate, hydrophilicity, and releasing profile), pharmacodynamics and pharmacokinetics properties, selectivity, and the therapeutic potentials of BBR 28 , 34 . BBR was reported as a potential anti-radical alkaloid that scavenges several free radicals such as DPPH, NO · , H 2 O 2 , O 2 − , lipid peroxidation, and ferric ions 35 , 36 and BBR NPs formulations were found to increase the radical scavenging activity 31 .…”

Section: Discussionmentioning

confidence: 99%

“…work 42 . Moreover, BBR-conjugated chitosan or alginate nanostructures revealed more potent antibacterial activities compared to BBR hydrochloride 34 .…”

Section: Discussionmentioning

confidence: 99%

Preparation, physicochemical characterization, and bioactivity evaluation of berberine-entrapped albumin nanoparticles

Younis

Saleh

El-Rahman

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Berberine (BBR) is an isoquinoline alkaloid with several clinical therapeutic applications. Its low water solubility, absorption, and cellular bioavailability diminish BBR's therapeutic efficacy. In this study, BBR was encapsulated into bovine serum albumin nanoparticles (BSA NPs) core to reduce BBR limitations and enhance its clinical therapeutic properties. Several physicochemical characterization tools, such as Dynamic Light Scattering and Ultraviolet–Visible spectroscopic measurements, field emission transmission electron microscopy surface morphology, Fourier transforms infrared spectroscopy, thermal stability analysis, and releasing studies, were used to evaluate the BBR-BSA NPs. Compared to BBR, BBR-BSA nanoparticles demonstrated superior free radical scavenging and antioxidant capacities, anti-hemolytic and anticoagulant efficacies, and antimicrobial activities, as demonstrated by the findings of the in vitro studies. Furthermore, a stressed pancreatic rat model was induced using a high-fat, high-sucrose diet plus carbon tetrachloride injection. The in vivo results revealed that BBR-BSA NPs substantially restored peripheral glucose metabolism and insulin sensitivity. Oral administration of BBR-BSA NPs also improved pancreatic β-cells homeostasis, upregulated pancreatic antioxidant mechanisms, inhibited oxidants generation, and attenuated oxidative injury in the stressed pancreatic tissues. In conclusion, our in vitro and in vivo results confirmed that BBR-BSA NPs demonstrated more potent antioxidant properties and restored pancreatic homeostasis compared to BBR.

show abstract

“…Remarkably, SETD7 also acts as a tumor suppressor in certain contexts and indeed is downregulated in some cancers; thus, a method by which to elevate SETD7 expression and increase its activity is also warranted. Berberine, an anticancer agent, is a major botanical alkaloid that can be isolated from the root of Rhizoma coptidis (Huanglian) ( Khan et al, 2022 ). Berberine can modulate various methylation- and acetylation-related enzymes that upregulate SETD7 expression in human multiple myeloma U266 cells in a dose-dependent manner ( Wang et al, 2016 ).…”

Section: Perspectives and Concluding Remarksmentioning

confidence: 99%

The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer

Chiang

Heng²,

Zhu³

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Epigenetic modifications are essential mechanism by which to ensure cell homeostasis. One such modification is lysine methylation of nonhistone proteins by SETD7, a mono-methyltransferase containing SET domains. SETD7 methylates over 30 proteins and is thus involved in various classical pathways. As such, SETD7 has been implicated in both the basic functions of normal tissues but also in several pathologies, such as cancers. In this review, we summarize the current knowledge of SETD7 substrates, especially transcriptional-related proteins and enzymes, and their putative roles upon SETD7-mediated methylation. We focus on the role of SETD7 in cancers, and speculate on the possible points of intervention and areas for future research.

show abstract

A review of the berberine natural polysaccharide nanostructures as potential anticancer and antibacterial agents

Cited by 28 publications

References 205 publications

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Preparation, physicochemical characterization, and bioactivity evaluation of berberine-entrapped albumin nanoparticles

The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer

Contact Info

Product

Resources

About