Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong, Ruo-Gu; Huang, Siyu; Wu, Si-Xia; Zhou, Dan-Dan; Yang, Zhijun; Saimaiti, Adila; Zhao, Cong; Shang, Ao; Zhang, Yunjian; Gan, Ren‐You; Li, Hua Bin

doi:10.3390/molecules27144523

Cited by 50 publications

(35 citation statements)

References 133 publications

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“…Berberine is an isoquinoline alkaloid [23]. Studies have shown that Berberine has a good broad-spectrum antibacterial effect and can inhibit bacteria as well as having strong anti-inflammatory and some immunomodulatory effects [24,25].…”

Section: Discussion：mentioning

confidence: 99%

A computer simulation-based study on the intervention of active ingredients of Mongolian medicine into the S-protein of SARS-CoV-2-associated variant Omicron

Bao

Morigentu

et al. 2022

Preprint

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BACKGROUND: Omicron VOC (BF.7) is a variant of SARS-CoV-2 that is currently spreading globally as a dominant strain. BF.7 is more infectious than existing Omicron variants, and to date there are no specific therapeutic agents for this variant. METHODS: The active compounds were collected by TCMSP, ETCM database and literature mining method, and the targets of the compounds were searched by Swiss Target Prediction and SUPERPRED database, while the targets of Omiron virus were collected by DisGeNET and GEO database, and then the intersecting targets were compared and analyzed. In this study, Swiss-Model was applied to construct the Spike RBD structure of Omicron variant BF.7 by replacing mutant amino acids into the Native Spike (S) structure, and the structural changes of Native S were compared. The four active compounds screened were docked with Omicron S protein and Omicron S-hACE2 complexes. To evaluate the structural stability of the complexes in a physiological environment, we also performed molecular dynamics simulations of the docked complexes and compared them to the control drug, chloroquine. The affinity of ligands and protein complexes was determined by free energy analysis using the MM-PBSA algorithm, and the structural changes of S proteins in combination with ligands were evaluated. RESULTS: A total of 12 mongolic medicines were screened and 310 active ingredient predictions were made, with a total of 55 genes overlapping with Omicron variants and 14 targets with the largest differences being conserved. Once these 14 targets were mapped to the active ingredients of 12 mongolic herbs, four more precise active ingredients were filtered out. Of these four phytochemicals, Berberine was the most potent inhibitor of Omicron S protein. In addition, molecular docking simulations revealed that Berberine can bind stably to Omicron S protein and the Omicron S-hACE2 complex. Using molecular dynamics simulations, Berberine was shown to be able to form a stable complex with Omicron S in a physiological environment with better results than the control drug chloroquine. Free energy analysis by the MM-PBSA algorithm and evaluation of S protein structural changes following ligand binding also demonstrated a higher affinity of Berberine for Omicron S compared to the other small molecule compounds. CONCLUSION: Berberine was found to have the most substantial inhibitory potential against Omicron VOC (BF.7) S protein and could be further investigated and developed as a potential inhibitor of Omicron.

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Section: Discussion：mentioning

confidence: 99%

A computer simulation-based study on the intervention of active ingredients of Mongolian medicine into the S-protein of SARS-CoV-2-associated variant Omicron

Bao

Morigentu

et al. 2022

Preprint

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“…In addition to breast cancer and glioblastoma, BBR has shown promising effects on other types of cancers, such as lung, gastric, liver, ovarian, colorectal, cervical, prostate, pancreatic bladder, endometrial, and esophageal cancers. The common mechanisms of action of BBR on cancer involve primarily inhibiting inflammation, suppressing cell proliferation and migration/metastasis, arresting cell cycle, and inducing apoptosis [98].…”

Section: Effect Of Berberine On Apoptosis and Necrosis Of Transformed...mentioning

confidence: 99%

Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells

Alam¹,

Kulka²,

Wang³

2023

Preprint

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Berberine (BBR) is an isoquinoline that inhibits the proliferation of transformed cells in vitro, but due to its poor solubility and bioavailability, it has only moderate therapeutic potential in vivo. Increasing evidence indicates that BBR specifically targets several metabolic, signaling and gene transcription events in transformed cells, altering their progression through the cell cycle and decreasing their metabolic rate and proliferation. In order to further develop BBR as a therapeutic, its mode of cellular internalization and localization within the cell needs to be further examined. BBR’s molecular targets and interactions with kinases, transcription factors and some enzymes are discussed in an attempt to better understand BBR’s role in these important pathways and how they may lead to changes in metabolism. Lastly, this review examines some of the benefits and challenges of using BBR as an inhibitor in cancer cell proliferation in breast cancer and glioblastoma, as two examples. BBR is a potent drug with multiple targets and it is this multiplicity of function that makes BBR such a promising drug for targeting cell metabolism and proliferation.

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“…Furthermore, low dose of curcumin treatment could exert anxiolytic effect through improving the synaptic plasticity to enhance neural circuits, but high dose of curcumin reversed anxiolytic effect because of inducing neuroinflammation to affect hippocampal neurogenesis [ 131 ]. This also could be because antioxidants with low dose would show antioxidant activity in vivo, but they with high dose would exhibit pro-oxidative activity in vivo [ 132 , 133 , 134 ]. Additionally, in a cadmium-exposed mouse model, curcumin decreased anxiety-like behaviors by promoting the production of viable prefrontal cortex neuronal cells, and suppressing neuroinflammation in prefrontal cortex [ 135 ].…”

Section: Anxietymentioning

confidence: 99%

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Zhou

et al. 2022

Antioxidants

Self Cite

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Depression and anxiety are severe public health problems and have attracted more and more attention from researchers of food science and nutrition. Dietary natural products and nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, and dietary fiber, could play a vital role in the prevention and management of these diseases. The potential mechanisms of action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating the microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, and regulating the levels of monoamine neurotransmitters. In this narrative review, we summarize the most recent advancements regarding the effects of dietary natural products and nutrients on depression and anxiety, and their underlying mechanisms are discussed. We hope that this paper can provide a better understanding of the anti-depressive and anxiolytic action of dietary natural products, and that it is also helpful for developing dietary natural products for functional food, dietary supplements, or auxiliary agents for the prevention and management of these diseases.

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Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Cited by 50 publications

References 133 publications

A computer simulation-based study on the intervention of active ingredients of Mongolian medicine into the S-protein of SARS-CoV-2-associated variant Omicron

A computer simulation-based study on the intervention of active ingredients of Mongolian medicine into the S-protein of SARS-CoV-2-associated variant Omicron

Unravelling the Effects of Berberine on Metabolic Activity, Apoptosis and Proliferation of Transformed Cells

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

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