A review of sources, multimedia distribution and health risks of novel fluorinated alternatives

Yü, Wang; Chang, Wenguang; Wang, Ling; Zhang, Yinfeng; Zhang, Yuan; Wang, Man; Yin, Wen; Li, Peifeng

doi:10.1016/j.ecoenv.2019.109402

Cited by 196 publications

(81 citation statements)

References 42 publications

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“…[23][24][25][26][27][28][29] Reports and books that address uorosurfactants and uoropolymers in general were also included. 3,8,12,16,20,21,[32][33][34][35][36][37][38][39][40][41][42][43] Literature specic to certain use categories was retrieved for more information either on the substances used, or to understand why PFAS are, or were, necessary for a given use. All specic references are cited in the ESI-1.…”

Section: Literature Sourcesmentioning

confidence: 99%

An overview of the uses of per- and polyfluoroalkyl substances (PFAS)

Glüge

Scheringer

Cousins

et al. 2020

Environ. Sci.: Processes Impacts

742

531

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Section: Literature Sourcesmentioning

confidence: 99%

An overview of the uses of per- and polyfluoroalkyl substances (PFAS)

Glüge

Scheringer

Cousins

et al. 2020

Environ. Sci.: Processes Impacts

742

531

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“…Many studies show that in strongly anthropized environments the above cited empirical descriptors meet the criteria to define PFCs as bioaccumulative substances [25,77] although, for specific substances such as PFOA, values of BCF and BAF are not always above the bioaccumulative threshold [71]. Since any of the bioaccumulative factors is determined based on a specific organism/tissue and can be evaluated in various geographical areas, it is important to analyse data from different studies to define the bioaccumulative potential of a specific polyfluorinated organic substance.…”

Section: Bioaccumulation Datamentioning

confidence: 99%

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Savoca

Pace

2021

IJMS

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This review is a survey of recent advances in studies concerning the impact of poly- and perfluorinated organic compounds in aquatic organisms. After a brief introduction on poly- and perfluorinated compounds (PFCs) features, an overview of recent monitoring studies is reported illustrating ranges of recorded concentrations in water, sediments, and species. Besides presenting general concepts defining bioaccumulative potential and its indicators, the biodistribution of PFCs is described taking in consideration different tissues/organs of the investigated species as well as differences between studies in the wild or under controlled laboratory conditions. The potential use of species as bioindicators for biomonitoring studies are discussed and data are summarized in a table reporting the number of monitored PFCs and their total concentration as a function of investigated species. Moreover, biomolecular effects on taxonomically different species are illustrated. In the final paragraph, main findings have been summarized and possible solutions to environmental threats posed by PFCs in the aquatic environment are discussed.

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“…“Short chain” PFASs are generally thought to be less harmful; however, their effects on the human body and environment are less understood. 45 − 47 The influence of basic and acidic residues upon the interactions has been investigated, as has the impact of l -carnitine and its interaction with different binding pockets.…”

Section: Introductionmentioning

confidence: 99%

Binding of Per- and Polyfluoro-alkyl Substances to Peroxisome Proliferator-Activated Receptor Gamma

2021

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Peroxisome proliferator receptor gamma (PPARγ), a type II nuclear receptor, fundamental in the regulation of genes, glucose metabolism, and insulin sensitization has been shown to be impacted by per- and poly-fluoroalkyl substances (PFASs). To consider the influence of PFASs upon PPARγ, the molecular interactions of 27 PFASs have been investigated. Two binding sites have been identified on the PPARγ homodimer structure: the dimer pocket and the ligand binding pocket, the former has never been studied prior. Molecular dynamics calculations were performed to gain insights about PFASs-PPARγ binding and the role of acidic and basic residues. The electrostatic interactions for acidic and basic residues far from the binding site were probed, together with their effect on PPARγ recognition. Short-range electrostatic and van der Waals interactions with nearby residues and their influence on binding energies were investigated. As the negative effects of perfluorooctane sulfonate acid were previously shown to be alleviated by one of its natural ligands, l -carnitine, here, the utility of l -carnitine as a possible inhibitor for other PFASs has been considered. A comparison of the binding patterns of l -carnitine and PFASs provides insights toward mitigation strategies for PFASs.

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A review of sources, multimedia distribution and health risks of novel fluorinated alternatives

Cited by 196 publications

References 42 publications

An overview of the uses of per- and polyfluoroalkyl substances (PFAS)

An overview of the uses of per- and polyfluoroalkyl substances (PFAS)

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Binding of Per- and Polyfluoro-alkyl Substances to Peroxisome Proliferator-Activated Receptor Gamma

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