A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases

Choonara, Yahya E.; Pillay, Viness; Danckwerts, Michael P.; Carmichael, Trevor; Toit, Lisa C. du

doi:10.1002/jps.21987

Cited by 115 publications

(101 citation statements)

References 113 publications

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“…When a drug needs to be released from a reservoir in the active device, a voltage is applied, which causes electrochemical dissolution of the gold anode membrane. Active systems include mechanical pumping, electrolysis and other actuation methods (Mansoor et al, 2009;Choonara et al, 2010;Eljarrat-Binstock et al, 2010). In contrast, the passive polymeric device contains biodegradable polymer membranes.…”

Section: Theory Of Operationmentioning

confidence: 99%

Implantable microchip: the futuristic controlled drug delivery system

2014

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There is no doubt that controlled and pulsatile drug delivery system is an important challenge in medicine over the conventional drug delivery system in case of therapeutic efficacy. However, the conventional drug delivery systems often offer a limited by their inability to drug delivery which consists of systemic toxicity, narrow therapeutic window, complex dosing schedule for long term treatment etc. Therefore, there has been a search for the drug delivery system that exhibit broad enhancing activity for more drugs with less complication. More recently, some elegant study has noted that, a new type of micro-electrochemical system or MEMS-based drug delivery systems called microchip has been improved to overcome the problems related to conventional drug delivery. Moreover, micro-fabrication technology has enabled to develop the implantable controlled released microchip devices with improved drug administration and patient compliance. In this article, we have presented an overview of the investigations on the feasibility and application of microchip as an advanced drug delivery system. Commercial manufacturing materials and methods, related other research works and current advancement of the microchips for controlled drug delivery have also been summarized.

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Section: Theory Of Operationmentioning

confidence: 99%

Implantable microchip: the futuristic controlled drug delivery system

2014

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“…These microrobotic devices are non-bioerrodable, and are rendered biocompatible using polypyrrole coatings [9]. Since the human eye, in general, has "immune privileges" that limit the risk of an inflammatory reaction to foreign antigens [10], severe reactions from the immune system due to the presence of coated microdevices is not expected.…”

Section: Electromagnetically Steerable Intravitreal Insertsmentioning

confidence: 99%

Steerable Intravitreal Inserts for Drug Delivery: In Vitro and Ex Vivo Mobility Experiments

Bergeles

Kummer

Kratochvil

et al. 2011

Lecture Notes in Computer Science

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Abstract. The progress of wet age-related macular degeneration can now be controlled by intravitreal drug injection. This approach requires repeated injections, which could be avoided by delivering the drug to the retina. Intraocular implants are a promising solution for drug delivery near the retina. Currently, their accurate placement is challenging, and they can only be removed after a vitrectomy. In this paper, we introduce an approach for minimally invasive retinal drug delivery using magnetic intraocular inserts. We briefly discuss the electromagnetic-control system for magnetic implants and then focus on evaluating their ability to move in the vitreous humor. The mobility of magnetic intraocular implants is estimated in vitro with synthesized vitreous humors, and ex vivo with experiments on cadaver porcine eyes. Preliminary results show that with such magnetic implants a vitrectomy can be avoided.

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“…In order to make drug delivery more efficient for vitreoretinal diseases, 2 major pathways have been developed to: intravitreal and subrentinal drug delivery. Intravitreal drug delivery has been a dominant method in treating vitreoretinal diseases for the last few decades, and it comprises direct intravitreal injection and intravitreal implantable device technology as well as bioerodible and nonbioerodible intravitreal implantable devices [22] . Via this effective technique, clinicians can administer drugs such as anti-VEGF [23][24][25][26][27] and steroids [28][29][30][31] , among others, or gene therapy such as vectors containing specific genes [32][33][34] , stem cells [35,36] , etc., directly into the back of the eye to increase drug concentration in the vitreous and the retina.…”

Section: Overview Of Subretinal Injectionmentioning

confidence: 99%

Subretinal Injection: A Review on the Novel Route of Therapeutic Delivery for Vitreoretinal Diseases

Peng

Tang

Zhou³

2017

Ophthalmic Res

130

117

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Compared to intravitreal injection, subretinal injection has more direct effects on the targeting cells in the subretinal space, which provides a new therapeutic method for vitreoretinal diseases, especially when gene therapy and/or cell therapy is involved. To date, subretinal delivery has been widely applied by scientists and clinicians as a more precise and efficient route of ocular drug delivery for gene therapies and cell therapies including stem cells in many degenerative vitreoretinal diseases, such as retinitis pigmentosa, age-related macular degeneration, and Leber's congenital amaurosis. However, clinicians should be aware of adverse events and possible complications when performing subretinal delivery. In the present review, the subretinal injection used in vitreoretinal diseases for basic research and clinical trials is summarized and described. Different methods of subretinal delivery, as well as its benefits and challenges, are also briefly introduced.

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A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases

Cited by 115 publications

References 113 publications

Implantable microchip: the futuristic controlled drug delivery system

Implantable microchip: the futuristic controlled drug delivery system

Steerable Intravitreal Inserts for Drug Delivery: In Vitro and Ex Vivo Mobility Experiments

Subretinal Injection: A Review on the Novel Route of Therapeutic Delivery for Vitreoretinal Diseases

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