Steerable Intravitreal Inserts for Drug Delivery: In Vitro and Ex Vivo Mobility Experiments

Bergeles, Christos; Kummer, M.P.; Kratochvil, Bradley E.; Framme, Carsten; Nelson, Bradley J.

doi:10.1007/978-3-642-23623-5_5

Cited by 27 publications

(19 citation statements)

References 15 publications

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“…Microrobotics is one of the newest research areas in surgical robotics. Microrobots have been proposed for various applications, e.g., arterial plaque removal [10], intravascular drug delivery [124], intraocular drug delivery [125], drug delivery in the brain [126]. A thorough review of state-of-the-art systems can be found in [25].…”

Section: E Untethered Microsurgeons -4 Th Generationmentioning

confidence: 99%

From Passive Tool Holders to Microsurgeons: Safer, Smaller, Smarter Surgical Robots

Bergeles

Yang

2014

IEEE Trans. Biomed. Eng.

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181

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Abstract-Within only a few decades from its initial introduction, the field of surgical robotics has evolved into a dynamic and rapidly growing research area with increasing clinical uptake worldwide. Initially introduced for stereotaxic neurosurgery, surgical robots are now involved in an increasing number of procedures, demonstrating their practical clinical potential whilst propelling further advances in surgical innovations. Emerging platforms are also able to perform complex interventions through only a single entry incision, and navigate through natural anatomical pathways in a tethered or wireless fashion. New devices facilitate superhuman dexterity and enable the performance of surgical steps that are otherwise impossible. They also allow seamless integration of micro-imaging techniques at the cellular level, significantly expanding the capabilities of surgeons. This paper provides an overview of the significant achievements in surgical robotics and identifies the current trends and future research directions of the field in making surgical robots safer, smaller, and smarter.

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Section: E Untethered Microsurgeons -4 Th Generationmentioning

confidence: 99%

From Passive Tool Holders to Microsurgeons: Safer, Smaller, Smarter Surgical Robots

Bergeles

Yang

2014

IEEE Trans. Biomed. Eng.

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181

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“…Other investigators have also proposed intraocular robots as a minimally invasive mechanism to provide a high degree of mobility and precision in the placement of intravitreal inserts for treatment of exudative age related macular degeneration. Using micro robots with an outer diameter of less than 500 µm, the authors were able to achieve targeted placement of drug reservoirs in porcine eyes using wireless electromagnetic controls [12].…”

Section: Previous Advancements In Robot-assisted Ophthalmic Surgerymentioning

confidence: 99%

Robotic Eye Surgery: Past, Present, and Future

Pitcher¹

2012

J Comput Sci Syst Biol

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Purpose: To review past attempts, current innovations, and future goals of robotic eye surgery. Methods:A Medline literature search using the words "robot" and "ophthalmology" was performed to identify all relevant literature. Pertinent articles were reviewed and content summarized based on context. Results:Purported potential benefits of robotic-assisted eye surgery include improved precision, reduced tremor, amplified scale of motion, and the potential of automation and telesurgical operation. Several investigators have created devices capable of performing individual intraocular tasks, and efforts are underway to develop platforms designed to allow completion of entire ophthalmic procedures. Conclusion:Although obstacles such as cost and availability exist, prior successes and future benefits of robotic eye surgery are promising reasons for the continuation of research efforts.

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“…Blood can be modeled with a Newtonian viscosity for flows in large arteries, but this approximation fails to hold for the flow in capillaries where the diameter of the blood vessel is similar in scale to the individual RBCs. The vitreous humor is an even more complex fluid, exhibiting viscoelastic properties and containing collagen fibers [2], [6].…”

Section: B Fluids In the Human Bodymentioning

confidence: 99%

Movement of artificial bacterial flagella in heterogeneous viscous environments at the microscale

Peyer

Qiu

Zhang

et al. 2012

2012 IEEE/RSJ International Conference on Intelligent Robots and Systems

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Abstract-Swimming microrobots have the potential to be used in medical applications such as targeted drug delivery. The challenges for navigating microrobots in the human body lie not only in the viscosity of body fluids but also in the existence of different types of fibers and cells such as blood cells or protein strands. This paper investigates artificial bacterial flagella (ABFs), which are helical microrobots actuated by an external magnetic field, in methyl cellulose solutions of different concentrations. It can be shown that the microrobots can be propelled in these gel-like heterogeneous solutions and successful swimming was demonstrated in solutions with a viscosity of more than 20 times that of water. Furthermore, results indicate that the existence of fibers can help ABFs swim more effectively, which agrees with previous experimental results reported for natural bacteria.

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Steerable Intravitreal Inserts for Drug Delivery: In Vitro and Ex Vivo Mobility Experiments

Cited by 27 publications

References 15 publications

From Passive Tool Holders to Microsurgeons: Safer, Smaller, Smarter Surgical Robots

From Passive Tool Holders to Microsurgeons: Safer, Smaller, Smarter Surgical Robots

Robotic Eye Surgery: Past, Present, and Future

Movement of artificial bacterial flagella in heterogeneous viscous environments at the microscale

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