A review of histopathological and immunohistochemical parameters in diagnosis of metastatic renal cell carcinoma with a case of gingival metastasis

Sikka, Seema; Sikka, Pranav; Kaur, Geetpriya; Shetty, Devi Charan

doi:10.4103/0973-1482.110395

Cited by 15 publications

(13 citation statements)

References 7 publications

(20 reference statements)

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“…Discussion Although 125 I brachytherapy has been successfully applied in many solid tumors, our study is the first to use this modality in the treatment of oral and maxillofacial metastases [19]. It is significant because patients with oral and maxillofacial metastases can often feel the presence of these lesions and have obvious clinical symptoms in these regions [20,21]. Palliative radiotherapy can alleviate the clinical symptoms to some extent, but its side effects and complications are significant [22,23].…”

Section: Osmentioning

confidence: 90%

CT-Guided 125 I Brachytherapy in the Treatment of Distant Metastases in the Oral Cavity and Maxillofacial Region

et al. 2017

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Section: Osmentioning

confidence: 90%

CT-Guided 125 I Brachytherapy in the Treatment of Distant Metastases in the Oral Cavity and Maxillofacial Region

et al. 2017

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“…It is significant because patients with oral and maxillofacial metastases can often feel the presence of these lesions and have obvious clinical symptoms in these regions [20], [21]. Palliative radiotherapy can alleviate the clinical symptoms to some extent, but its side effects and complications are significant [22], [23].…”

Section: Discussionmentioning

confidence: 99%

CT-guided 125I brachytherapy in the treatment of distant metastases in the oral cavity and maxillofacial region

Yan

Xiang²,

Zhong³

et al. 2017

Translational Oncology

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PURPOSE: We aimed to evaluate the feasibility and clinical effectiveness of CT-guided 125I brachytherapy for distant oral and maxillofacial metastases. MATERIALS AND METHODS: We retrospectively analyzed 65 patients with 84 distant oral and maxillofacial metastases. Thirty-one patients with 38 lesions received 125I brachytherapy (group A) and 34 with 46 lesions received external beam radiotherapy (EBRT; group B). RESULTS: Median follow-up time was 16 months. The 3-, 6-, 12-, 18-, and 24-month local control rates for group A were 83.9%, 75.9%, 66.7%, 38.4%, and 25.0%, respectively; for group B they were 76.5%, 62.5%, 43.8%, 25.0%, and 0.0%, respectively (P < .05); the median local tumor progression-free survival times were 14 and 9 months, respectively. Group A had a better local tumor progression-free survival (LTPFS) relative to group B (P < .001; HR, 6.961 [95%CI, 2.109, 9.356]). Cox proportional hazards regression analysis indicated that 125I brachytherapy, tumor size, and primary pathological type were the independent factors affecting LTPFS. Additionally, 125I brachytherapy showed better performance in relieving patient clinical symptoms relative to EBRT (P < .05). Group A also had fewer complications than group B, especially regarding grade 3/4 complications according to Radiation Therapy Oncology Group grading criteria. Mean overall survival times in groups A and B were 17.1 and 14.8 months, respectively. CONCLUSION: CT-guided 125I brachytherapy is feasible and safe for distant oral and maxillofacial metastases; it achieved a better local control rate, longer LTPFS and fewer complications without compromising overall survival compared with EBRT.

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“…It usually affects men aged 30-60 years [3] and can metastasize to any part of the body, with a 15% risk of metastasis to the head and neck area when the disease is disseminated and 1% risk when it is not. RCC accounts for 2% of all cancer deaths [4].…”

Section: Introductionmentioning

confidence: 99%

“…Sites of renal carcinoma metastases are usually found in the lungs, bones, lymph nodes, and liver [4].…”

Section: Introductionmentioning

confidence: 99%

Multiple gingival metastasis of renal cell carcinoma: a case report

Boulanger

Gérard

Curien

2019

J Oral Med Oral Surg

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Introduction: Oral metastases are rare and represent only 1% of malignant diseases of the oral cavity, but they are often associated with poor prognosis. The primary tumor is recognizable in most cases; however, in 27.6% of cases, metastasis is the first clinical manifestation. Observation: An 82-year-old consulted for the recent appearance of a 1-cm-wide gingival tumor on 46. Since this patient had metastatic clear cell renal cell carcinoma, oral metastasis was confirmed by histopathology. In the following weeks, other oral metastases appeared. Palliative radiotherapy was the chosen treatment option, but the patient died before he could benefit from it. Discussion: Multiple oral metastases are rare, and metastasis of renal origin is not the most frequently encountered. The metastatic dissemination pathway described is hematogenous or lymphatic. Diagnosis is often easy if the primary tumor is already identified, but is a challenge if it is not, because the lesion often has a nonspecific appearance. Different surgical, radiotherapeutic, and medical therapeutic options exist, but are often palliative. A new immunotherapy route is under development and looks promising in the treatment of renal cell carcinoma. Conclusions: Oral metastasis often has poor prognosis, and management of the lesion is problematic. However, current research suggests a therapeutic and prognostic improvement.

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A review of histopathological and immunohistochemical parameters in diagnosis of metastatic renal cell carcinoma with a case of gingival metastasis

Cited by 15 publications

References 7 publications

CT-Guided 125 I Brachytherapy in the Treatment of Distant Metastases in the Oral Cavity and Maxillofacial Region

CT-Guided 125 I Brachytherapy in the Treatment of Distant Metastases in the Oral Cavity and Maxillofacial Region

CT-guided 125I brachytherapy in the treatment of distant metastases in the oral cavity and maxillofacial region

Multiple gingival metastasis of renal cell carcinoma: a case report

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