CT-Guided 125 I Brachytherapy in the Treatment of Distant Metastases in the Oral Cavity and Maxillofacial Region

Yan, Huzheng; Zhang, Fujun; Gao, Fei; Mo, Zhiqiang

doi:10.1016/j.brachy.2017.04.179

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…A clinical trial (n = 81) evaluating the efficacy of I-125 BT in locally recurrent NPC when compared with external beam re-radiotherapy reported a higher median local tumor PFS (LTPFS; 21 vs. 17 months, p = 0.015), without meaningfully impacting OS ( 85 ). Another study reported that the median LTPFS time (14 vs. 9 months, p < 0.001) of I-125 BT in treating distant metastases in the oral and maxillofacial region compared to EBRT was also higher ( 86 ). Moreover, several single-arm clinical studies suggested that I-125 BT performed exceptionally well in various head and neck cancers, including primary mucoepidermoid carcinoma of the parotid gland (10-year OS rate of 95.8%), adenoid cystic carcinoma (ACC) involving the skull base (3-year OS rate of 62.6% and 3-year PFS rates of 46.4%), and salivary gland carcinomas of the lip and buccal mucosa (10-year LC rate of 82.9% and 10-year OS rate of 77.8%) ( 111 – 113 ).…”

Section: I-125 Brachytherapy In Solid Tumorsmentioning

confidence: 99%

Radioactive Iodine-125 in Tumor Therapy: Advances and Future Directions

Wei

Mengyuan

et al. 2021

Front. Oncol.

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Radioactive iodine-125 (I-125) is the most widely used radioactive sealed source for interstitial permanent brachytherapy (BT). BT has the exceptional ability to deliver extremely high doses that external beam radiotherapy (EBRT) could never achieve within treated lesions, with the added benefit that doses drop off rapidly outside the target lesion by minimizing the exposure of uninvolved surrounding normal tissue. Spurred by multiple biological and technological advances, BT application has experienced substantial alteration over the past few decades. The procedure of I-125 radioactive seed implantation evolved from ultrasound guidance to computed tomography guidance. Compellingly, the creative introduction of 3D-printed individual templates, BT treatment planning systems, and artificial intelligence navigator systems remarkably increased the accuracy of I-125 BT and individualized I-125 ablative radiotherapy. Of note, utilizing I-125 to treat carcinoma in hollow cavity organs was enabled by the utility of self-expandable metal stents (SEMSs). Initially, I-125 BT was only used in the treatment of rare tumors. However, an increasing number of clinical trials upheld the efficacy and safety of I-125 BT in almost all tumors. Therefore, this study aims to summarize the recent advances of I-125 BT in cancer therapy, which cover experimental research to clinical investigations, including the development of novel techniques. This review also raises unanswered questions that may prompt future clinical trials and experimental work.

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