A review of blood dyscrasias induced by the antituberculosis drugs

Holdiness, Mack R.

doi:10.1016/0041-3879(87)90072-9

Cited by 32 publications

(12 citation statements)

References 47 publications

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“…Previous studies showed that exposure to anti‐TB drugs can result in chromosome aberrations, sister chromatid exchanges, and aneuploidy [14]. Blood dyscarasias such as neutropenia, agranulosis, esinophilia, and thrombocytopenia have been linked to anti‐TB drugs [15]. It is possible that genotoxic effects of anti‐TB drugs may contribute to the MDS development.…”

Section: Discussionmentioning

confidence: 99%

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

Lin

Gao

et al. 2011

American J Hematol

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Risk factors of mydelodysplastic syndromes (MDS) remain largely unknown. We conducted a hospital-based case-control study consisting of 403 newly diagnosed MDS patients according to World Health Organization classification and 806 individually gender and age-matched patient controls from 27 major hospitals in Shanghai, China, to examine relation of lifestyle, environmental, and occupational factors to risk of MDS. The study showed that all MDS (all subtypes combined) risk factors included anti tuberculosis drugs [odds ratio (OR) IntroductionMyelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic clonal stem cell disorders characterized by clinical presentations of anemia, thrombocytopenia, and leucopenia. MDS may be categorized into subtypes according to histological, immunological, and genetic characteristics. MDS was usually diagnosed by French-American-British (FAB) classification with subtypes including refractory anemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-T), and chronic myelomonocytic leukemia (CMML) [1]. Since its publication in 2001, World Health Organization (WHO) classification for MDS has become widely adopted [2]. In the WHO MDS system, blast cutoff is less than 20% compared to 30% in FAB system. Additional WHO MDS subtypes include refractory cytopenia with multiple dysplasia (RCMD), MDS with isolated del(5q), and MDS unclassifiable (MDS-u) and the WHO MDS system does not include CMML [3].Secondary MDS is usually resulted from radiation and chemotherapy. Little is known about the etiology of primary or de novo MDS. Most previous studies on MDS risk factors focused on FAB MDS [4][5][6]. Here, we report a large hospital-based case-control study of 403 WHO MDS cases and 806 age and sex-matched controls in a Chinese population to assess effects of lifestyle, environmental, and occupational factors on MDS development.

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Section: Discussionmentioning

confidence: 99%

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

Lin

Gao

et al. 2011

American J Hematol

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“…All the other compounds did not show significant activity against the fungi at the concentration used. (1,5,15,16) shown significant activities and compound (2,4,9,12,14) have shown moderate activity. The same compounds were tested for their antifungal activity against Candida albicans, Aspergillus niger and Alternaria alternata at concentration of 30 mg/ mL using savored dextrose agar media.…”

Section: Anti-fungal Activitymentioning

confidence: 99%

Synthesis of Bis-Amide and Hydrazide Containing Derivatives of Malonic Acid and Thiophenoladducts of Acidhydrazones Derived from 2-[(N-acetyl) 2, 5-dichloroanilido] Acetohydrazide

Sharma¹,

Sharma²,

Dikshit³

2011

Biomed. Pharmacol. J.

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Acidhydrazides and their condensation products possessing an azometine-NHN=CH-Proton constitute an important class of compounds for new drug development. In the past several years, numerous compounds with diverse structural features have been reported. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. Hydrazides, hydrazones and their adducts have displayed diverse range of biological properties such as potential biological activities 1-6 , anti-viral 7-8 , anti-tuberculosis 9-10 , anti-tumor 11-18 , anti-fungal 19-20 , anti-convulsant 21 , anti-helmintic 22 , anti-malarial 23 , anti-Inflammatory 24 , anti-cancer 25-26 , antiproliferative 27-29 , anti-oxidant 30 , agricultural agents 31 .

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“…They have a promising location in the design and production of proficient biologically active materials and still continue to draw attention due to their broad spectrum and diversity [8]. Moreover, their derivatives showed important roles in valued biological activities [9][10][11], antinflammation [12,13], against malaria [14], antituberculosis [15][16][17][18][19][20][21], and anticancer [22].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis and Antibacterial Activity of Pyrido[2,3-e]1,3,4-Oxadiazine Derivatives

Eissa¹,

Sayed²,

Sharkawi³

2019

AJHC

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Pyrido[2,3-e]1,3,4-Oxadiazines heterocyclic ring system and its derivatives were efficiently synthesized via benign and sustainable methodology using Grinding Chemistry as a recognized solvent free, less hazard, and low risk pathway. The course of the reaction was completed by refluxing using ecofriendly and renewable source of initiation energy via means of parabolic solar reflectors. The implemented parabolic solar reflectors employed the direct sunlight as a clean and sustainable source of activation energy to activate the required chemical reaction. The green context of the procedure was evaluated and discussed by comparing its benign components with the non-green components of the conventional one. The green components of the green procedures were found virtually preferred over the conventional one with its simplicity, time efficiency, atom economy, safety, sustainability, low cost, yield optimization, excellent conversion of the reactants and ease of applicability. The biological activity of the prepared compounds was evaluated and discussed against some bacterial strains naming, (Escherichia Coli, Pseudomonas, Serratia and Bacillus Cereus), and was found to display promising anti-bacterial results that encourage future pharmaceutical studies to quantify its potency. All the synthesized compounds were purified using glass column chromatography packed with silica and their structures were identified and confirmed by elemental analysis and Mass spectra, 1 HNMR, 13 CNMR spectral data.

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A review of blood dyscrasias induced by the antituberculosis drugs

Cited by 32 publications

References 47 publications

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

Synthesis of Bis-Amide and Hydrazide Containing Derivatives of Malonic Acid and Thiophenoladducts of Acidhydrazones Derived from 2-[(N-acetyl) 2, 5-dichloroanilido] Acetohydrazide

Green Synthesis and Antibacterial Activity of Pyrido[2,3-e]1,3,4-Oxadiazine Derivatives

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