A review of analytical methods for the determination of aminoglycoside and macrolide residues in food matrices

McGlinchey, Tara A.; Rafter, Paul; Regan, Fiona; McMahon, Gillian

doi:10.1016/j.aca.2008.05.054

Cited by 167 publications

(73 citation statements)

References 95 publications

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“…Application of the method for the analysis of incurred tulathromycin residues in bison serum, deer serum, and selected tissues The bison were administered a single 2.5 mg/kg body weight (bw) subcutaneous (SC) injection of Draxxin (Zoetis Canada, Kirkland, QC, Canada) in the lateral neck. Blood samples were collected in 10 mL serum vacutainer tubes by jugular venipuncture preinjection at 0, 1, 2, 4, 12 hours, and 1, 1.5, 2, 3, 4, 5,6,7,8,9,10,11,13,15,17,19,21,23, and 25 days post-injection. Serum was separated from blood samples by centrifugation (Eppendorf 5804 R Centrifuge) at 1500 x g for 10 min, transferred to micro-centrifuge tubes, and stored at À80°C until analysis.…”

Section: Experiments To Demonstrate Fit-for-purposementioning

confidence: 99%

“…Liquid chromatography coupled to mass spectrometry (LC-MS) has become standard practice in pharmacokinetic analysis for the analysis of drugs in food and biological samples due to its excellent sensitively and selectivity and the ability to quantify drugs at trace levels. [12][13][14][15][16] LC-MS methods have been reported for tulathromycin in plasma and tissue samples in cattle, [9,10,15] swine, [9,17,18] goats, [19][20][21] and foals. [22,23] There were, however, no reported methods for the determination of pharmacokinetic parameters in either the bison or the white-tailed deer.…”

Section: Introductionmentioning

confidence: 99%

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A single laboratory‐validated LC‐MS method for the analysis of tulathromycin residues in bison and deer sera and selected tissues of white‐tailed deer

Boison¹,

Bachtold

Matus

et al. 2016

Drug Testing and Analysis

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The performance characteristics of a newly developed liquid chromatography-mass spectrometry (LC-MS) method were validated and demonstrated to be fit for purpose in a pharmacokinetic and tissue depletion study of white-tailed deer and bison. Tulathromycin was extracted from bison and deer sera with acetonitrile or trifluoroacetic acid and K 2 HPO 4 (pH 6.8) buffer solution and cleaned up on a conditioned Bond-Elut cartridge. Tulathromycin, retained on the cartridge; it was eluted with methanol containing 2% formic acid, dried, re-constituted in methanol/1% formic acid, and analyzed by LC-MS. The limit of quantification (LOQ) of the method was 0.6 ng/mL in serum and 0.6 ng/g in tissue with RSDs ≤ 10% and accurate over the linear calibration range of 0.8-100 ng/mL for bison serum, 0.6-50 ng/mL for deer serum, 100-2500 ng/g for deer muscle tissue, and 500-5000 ng/g for deer lung tissue, all with coefficients of determination, r 2 ≥0.99. The validated method was used to quantify the concentration of tulathromycin residues in serum of bison and deer and selected tissue (lung and muscle tissue) samples obtained from 10 healthy, white-tailed deer that were administered the therapeutic dose approved for cattle (i.e., a single 2.5 mg/kg subcutaneous injection of tulathromycin in the neck). The deer were included in a tulathromycin drug depletion study.

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Section: Experiments To Demonstrate Fit-for-purposementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A single laboratory‐validated LC‐MS method for the analysis of tulathromycin residues in bison and deer sera and selected tissues of white‐tailed deer

Boison¹,

Bachtold

Matus

et al. 2016

Drug Testing and Analysis

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show abstract

“…The structure of lincomycin itself is of a five-membered cyclic amino amide, attached to a thioglycoside side-chain. Both classes of compound are used primarily in food-producing animals for the treatment of bacterial infections, such as mastitis [289]. The broad range of chemical functionalities associated with these compounds can thus pose a challenge to sample preparation.…”

Section: Macrolides and Lincosamidesmentioning

confidence: 99%

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

Kinsella

O’Mahony

Malone

et al. 2009

Journal of Chromatography A

180

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A comprehensive review is presented on the current trends in sample preparation for isolation of veterinary drugs and growth promotors from foods. The objective of the review is to firstly give an overview of the sample preparation techniques that are applied in field. The review will focus on new techniques and technologies, which improve efficiency and coverage of residues. The underlying theme to the paper is the developments that have been made in multi-residue methods and particularly multi-class methods for residues of licensed animal health products, which have been developed in the last couple of years. The role of multi-class methods is discussed and how they can be accommodated in future residue surveillance.

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“…After parenteral administration, they are excreted unchanged by glomerular filtration in the urine within 24 h. In recent years, AG antibiotics are less frequently applied in human medicine because of their severe adverse effects, such as oto-and nephrotoxicity, and also the availability of welltolerated β-lactam antibiotics. However, they are frequently used in veterinary medicine for the treatment of bacterial infections such as mastitis, or for prophylaxis to prevent infection [16]. Also, streptomycin has been used as pesticide to control bacterial diseases in certain fruits such as apples [17].…”

Section: Introductionmentioning

confidence: 99%

Determination of aminoglycoside antibiotics using an on-chip microfluidic device with chemiluminescence detection

2012

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We describe an on-chip microflow injection (μFI) approach for the determination of aminoglycoside antibiotics using chemiluminescence (CL) detection. The method is based on the inhibition of the Cu(II)-catalyzed CL reaction of luminol and hydrogen peroxide by the aminoglycosides due to the formation of a complex between the antibiotic and Cu(II). The main features of the method include small sample volumes and a fast response. Syringe pumps were used to insert the sample and the reagents into the microfluidic device. CL was collected using a fiber optic bundle connected to a luminescence detector. All instrumental, hydrodynamic and chemical variables involved in the system were optimized using neomycin as the aminoglycoside model. Inhibition is proportional to the concentration of the antibiotics. The dynamic ranges of the calibration graphs obtained for neomycin, streptomycin and amikacin are 0.3-3.3, 0.9-13.7, and 0.8-8.5 μmol L −1 , and the detection limits are 0.09, 0.28 and 0.24 μmol L −1 , respectively. The precision of the methods, expressed as relative standard deviation, is in the range from 0.8 to 5.0 %. The method was successfully applied to the determination of neomycin in water samples, with recoveries ranging from 80 to 120 %.

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A review of analytical methods for the determination of aminoglycoside and macrolide residues in food matrices

Cited by 167 publications

References 95 publications

A single laboratory‐validated LC‐MS method for the analysis of tulathromycin residues in bison and deer sera and selected tissues of white‐tailed deer

A single laboratory‐validated LC‐MS method for the analysis of tulathromycin residues in bison and deer sera and selected tissues of white‐tailed deer

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

Determination of aminoglycoside antibiotics using an on-chip microfluidic device with chemiluminescence detection

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