A review of 733 published trials on Bio-Mos®, a mannan oligosaccharide, and Actigen®, a second generation mannose rich fraction, on farm and companion animals.

Abstract

Mannan-oligosaccharides (MOS), as zootechnical feed ingredients, are widely used in animal nutrition. MOS has been commercially available since the launch of Bio-Mos® in the early 1990's and has a substantial body of scientific papers and practical examples of its efficacy. Since 1999, the use of MOS in animal feed has become more prominent, mainly due to the European ban on prophylactic antibiotic growth promoters in animal feed. MOS, with its ability to bind and limit the colonisation of gut pathogens, has proven to be an effective solution for antibiotic-free diets, as well as providing support for immunity and digestion. MOS has been shown to improve gastrointestinal health, thus improving wellbeing, energy levels and performance. Most MOS products, particularly those that have been scientifically developed, derive from the cell wall of the yeast, Saccharomyces cerevisiae. In 2009, a mannose-rich fraction (MRF) product was commercially launched as a 'second generation' of these MOS-type products, with enhanced activities in immune modulation and intestinal health. The purpose of this paper is to review the existing data on the benefits of MOS for all species of animals, discuss its mechanisms of action in vivo and compare the benefits of using second generation MRF to original MOS.

Multi‐strain yeast fraction product supplementation can alleviate weaning stress and improve performance and health of piglets raised under low sanitary conditions

“…In a review by Spring et al . it has been noted that dietary supplementation of MOS from yeast cells to various livestock species conferred positive effects in body weight gain and feed conversion.…”

A Meta-Analysis of the Inclusion of Bio-Mos® in Milk or Milk Replacer Fed to Dairy Calves on Daily Weight Gain in the Pre-Weaning Period

“…Mannan-oligosaccharides are prebiotics that have been shown to modify the gut microbial flora, increase the intestinal mucus-layer, improve intestinal immunity through interactions at the Peyer's patches and directly bind potential pathogens by binding to mannose-sensitive lectins [3,9]. The initial aim of the meta-analysis was to evaluate numerous performance and health parameters in pre-weaning calves supplemented with mannan-oligosaccharides.…”

“…Mannan-oligosaccharides are prebiotics derived from the cell wall of Saccharomyces cerevisiae that have been shown to optimize gut health and overall health in numerous production animals [3]. It has been showing consistent results across various production species in improving performance in terms of improved feed intake, feed efficiency and growth.…”

“…It has been showing consistent results across various production species in improving performance in terms of improved feed intake, feed efficiency and growth. Bio-Mos ® , Alltech's mannan-oligosaccharide based nutritional supplement derived from the cell wall of S. cerevisiae, have been most extensively researched and published [3].…”

“…Mannan-oligosaccharides can bind various pathogenic bacteria such as Escherichia coli and Salmonella enterica and it can modify and help to improve the composition of the intestinal microflora [3]. Mannan-oligosaccharides have been shown to improve faecal consistency, respiratory health, growth performance and increase concentrate intake [1,[4][5][6][7].…”