A retrospective study detects a novel variant of porcine epidemic diarrhea virus in England in archived material from the year 2000

Steinbach, Falko; Dastjerdi, Akbar; Peake, Julie; Rocca, S. Anna La; Tobin, Frank P.; Frossard, Jean-Pierre; Williamson, Susanna

doi:10.7717/peerj.2564

Cited by 4 publications

(6 citation statements)

References 15 publications

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“…Since spring 2014, outbreaks of diarrhoea affecting pigs of all age groups have also been reported in farms in Europe, firstly in Germany (Henniger and Schwarz, 2014;Hanke et al, 2015;Stadler et al, 2015), followed by its neighbouring countries, the Netherlands, Belgium, and Austria (Theuns et al, 2015;Steinrigl et al, 2015), as well as from the more distant Ukraine in summer 2014 . However, only the outbreak in the Ukraine was caused by a Colorado-like PEDV strain, whereas all the central European outbreaks were caused by the Ohio851-like variant.…”

Section: European Incursions Spread Circulating and Extinct Pedv Stmentioning

confidence: 99%

“…While most of the historic material held in our storage is from earlier passages of CV777, we also had material from one of the last GB PEDV cases in the year 2000 available for analysis (Steinbach et al, 2016). This PEDV strain, termed England-1-2000, is indeed significantly different not only to CV777, but also to all other previously known strains and can be seen as a prototype of a further genotype of PEDV (Fig.…”

Section: European Incursions Spread Circulating and Extinct Pedv Stmentioning

confidence: 99%

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From the field to the lab — An European view on the global spread of PEDV

et al. 2016

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Porcine Epidemic Diarrhea Virus (PEDV) is a member of the genus Alphacoronavirus, in the family Coronaviridae, of the Nidovirales order and outbreaks of porcine epidemic diarrhoea (PED) were first recorded in England in the 1970s. Intriguingly the virus has since successfully made its way around the globe, while seemingly becoming extinct in parts of Europe before its recent return from Northern America. In this review we are re-evaluating the spread of PEDV, its biology and are looking at lessons learnt from both failure and success. While a new analysis of PEDV genomes demonstrates a wider heterogeneity of PEDV than previously anticipated with at least five rather than two genotypes, biological features of the virus and its replication also point towards credible control strategies to limit the impact of this re-emerging virus.

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Section: European Incursions Spread Circulating and Extinct Pedv Stmentioning

confidence: 99%

Section: European Incursions Spread Circulating and Extinct Pedv Stmentioning

confidence: 99%

From the field to the lab — An European view on the global spread of PEDV

et al. 2016

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“…NON-INDEL strains subsume USA/Kansas29/2013 strains (GenBank accession number KJ645637.1). These viruses caused a more severe disease course and higher mortality compared to the S-INDEL strains (17,18,25,31). All PEDV pandemic strains circulating in China after 2014 were also clustered to genotype 2, and they were genetically separated from other global PEDV strains and from earlier Chinese strains (29).…”

Section: Pedv Structure and Genomementioning

confidence: 97%

“…The N protein has multiple functions in viral replication, interacts with viral genomic RNA, and associates with other N proteins to protect the viral genome. It disturbs antiviral responses by antagonising interferon production (17,31). The S protein is encoded by a gene sequence which determines the virulence of a PEDV strain (35).…”

Section: Pedv Structure and Genomementioning

confidence: 99%

Current status of porcine epidemic diarrhoea (PED) in European pigs

Antas

Woźniakowski

2019

Journal of Veterinary Research

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Porcine epidemic diarrhoea (PED) is a highly contagious and devastating enteric disease of pigs caused by porcine epidemic diarrhoea virus (PEDV), an enveloped, single-stranded RNA virus belonging to the Alphacoronavirus genus of the Coronaviridae family. The disease is clinically similar to other forms of porcine gastroenteritis. Pigs are the only known host of the disease, and the occurrence of PED in wild boars is unknown. The virus causes acute diarrhoea, vomiting, dehydration, and high mortality in suckling piglets reaching 100%. Heavy economic losses in the pig-farming industry were sustained in the USA between 2013 and 2015 when PEDV spread very quickly and resulted in epidemics. The loss in the US pig industry has been estimated at almost seven million pigs. The purpose of this review is a description of the current status of porcine epidemic diarrhoea in European pigs and the risk presented by the introduction of PEDV to Poland in comparison to the epidemics in the USA.

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“…Within the groups a certain variety can be distinguished, hence subgroups of strains have been described, namely G1a and G1b and G2a and G2b. In addition, the strains belonging to PEDV group G2 which have a deletion or insertion in the S gene were classified as S-INDEL variants from the originally isolated CV777 strain ( 87 , 96 , 97 ). The virus may spread with traded pigs that are asymptomatically infected and shed the virus into the environment with faeces.…”

Section: Pig Coronavirusesmentioning

confidence: 99%

Animal coronaviruses in the light of COVID-19

Domańska-Blicharz

Woźniakowski

Konopka

et al. 2020

Journal of Veterinary Research

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Coronaviruses are extremely susceptible to genetic changes due to the characteristic features of the genome structure, life cycle and environmental pressure. Their remarkable variability means that they can infect many different species of animals and cause different disease symptoms. Moreover, in some situations, coronaviruses might be transmitted across species. Although they are commonly found in farm, companion and wild animals, causing clinical and sometimes serious signs resulting in significant economic losses, not all of them have been classified by the World Organization for Animal Health (OIE) as hazardous and included on the list of notifiable diseases. Currently, only three diseases caused by coronaviruses are on the OIE list of notifiable terrestrial and aquatic animal diseases. However, none of these three entails any administrative measures. The emergence of the SARS-CoV-2 infections that have caused the COVID-19 pandemic in humans has proved that the occurrence and variability of coronaviruses is highly underestimated in the animal reservoir and reminded us of the critical importance of the One Health approach. Therefore, domestic and wild animals should be intensively monitored, both to broaden our knowledge of the viruses circulating among them and to understand the mechanisms of the emergence of viruses of relevance to animal and human health.

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A retrospective study detects a novel variant of porcine epidemic diarrhea virus in England in archived material from the year 2000

Cited by 4 publications

References 15 publications

From the field to the lab — An European view on the global spread of PEDV

From the field to the lab — An European view on the global spread of PEDV

Current status of porcine epidemic diarrhoea (PED) in European pigs

Animal coronaviruses in the light of COVID-19

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