A retrospective analysis of patients with gallbladder cancer: surgical treatment and survival according to tumor stage

Alonso, Iago Justo; Marcacuzco, Alberto; Nutu, Oana-Anisa; Manrique, Alejandro; Pulido, Jorge Calvo; Caso, Óscar; Cambra, F.; García-Sesma, Álvaro; Jiménez-Romero, Luis Carlos

doi:10.17235/reed.2018.5435/2017

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…All of them with metastatic, inoperable GBC (stage IV) died within 5 months of follow‐up after diagnostic confirmation because of delayed presentation and hepatic failure related to malignant obstructive jaundice. These results were in agreement with a few studies in the literature that reported the mortality rate of GBC was high and accounted for 3830 deaths in the United States 3,44–46 . The main strength of our study is the applicability of the updated patterns of clinical presentation and management modalities of GBC in Sudanese patients to reach excellent practice at Sudanese national surgical centers in spite of significant delay in the diagnosis of advanced GBC.…”

Section: Discussionsupporting

confidence: 91%

Clinical presentation and management modalities of gallbladder cancer in Sudan: A single‐center study

Adam¹,

Abdelrahim²,

Doush

et al. 2023

JGH Open

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Author contributions: Wael Mohialddin Doush was responsible for original manuscript writing, editing, supervision, and critical revision of contents. Wael Mohialddin Doush, Elfatih Yousif Abdelrahim, and Khatab M. Adam were responsible for data collection, data analysis, and manuscript design. Wael Mohialddin Doush and Muataz S. Abdelaziz were responsible for manuscript drafting and revision. All authors read and gave the final approval of the manuscript to be published. Financial support: No financial support or sponsorship was available for this study from any institution.

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Section: Discussionsupporting

confidence: 91%

Clinical presentation and management modalities of gallbladder cancer in Sudan: A single‐center study

Adam¹,

Abdelrahim²,

Doush

et al. 2023

JGH Open

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“…Gallbladder carcinoma is a very aggressive malignancy with a dismal prognosis and about 5-year survival. 1 The only chance for long-term survival is radical surgery mainly if patients are operated on in the early stage. In patients with resected gallbladder cancer, the presence of metastases in lymph nodes is an essential prognostic factor.…”

Section: Introductionmentioning

confidence: 99%

Lymph Node Ratio is an Important Prognostic Factor in Curatively Resected Gallbladder Carcinoma, Especially in Node-positive Patients: An Experience from Endemic Region in a Developing Country

Shah

Qari²,

Thau

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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“…Gallbladder cancer (GBC) is a relatively rare type of cancer, yet it accounts for more than 80 percent of all biliary tract malignancies [1,2]. Despite great improvement in clinical GBC treatment, most GBC patients are usually diagnosed at advanced stages with extremely ominous outcomes [3]. To date, our understanding regarding molecular mechanisms of GBC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

MiR-520b inhibits proliferation, migration and invasion in gallbladder carcinoma by targeting RAB22A

et al. 2021

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Introduction: Previous studies have reported that miR-520b exhibited inhibitory effects on various human tumors, whereas the effects of miR-520b on gallbladder carcinoma (GBC) have remained unclear. To investigate the effects of miR-520b on GBC progression and reveal the underlying mechanisms, this study was performed. Material and methods: MiR-520b and RAB22A mRNA levels were analyzed by quantitative real-time PCR (qPCR). RAB22A protein level was analyzed via Western blot and immunohistochemical (IHC) analysis. The proliferation, colony formation ability, migration and invasion of NOZ cells were measured via MTT, colony formation, wound healing and transwell invasion assay respectively. Results: MiR-520b expression level was lower in human GBC tissues than that in neighboring normal tissues. MiR-520b mimic repressed NOZ cell proliferation, colony formation ability, migration and invasion, whereas miR-520b inhibitor exhibited opposite effects. Dual luciferase reporter assay confirmed that miR-520b could bind to the 3′-untranslated regions of RAB22A mRNA. Moreover, RAB22A overexpression significantly abolished the anti-tumor effects of miR-520b in a NOZ cell model. Western blot, qPCR and IHC analysis proved that human GBC tissues showed a higher RAB22A expression level than neighboring normal tissues. Additionally, there was a negative association between miR-520b and RAB22A expression. Conclusions: MiR-520b had suppressive effects on GBC via targeting RAB22A in vitro.

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A retrospective analysis of patients with gallbladder cancer: surgical treatment and survival according to tumor stage

Cited by 7 publications

References 28 publications

Clinical presentation and management modalities of gallbladder cancer in Sudan: A single‐center study

Clinical presentation and management modalities of gallbladder cancer in Sudan: A single‐center study

Lymph Node Ratio is an Important Prognostic Factor in Curatively Resected Gallbladder Carcinoma, Especially in Node-positive Patients: An Experience from Endemic Region in a Developing Country

MiR-520b inhibits proliferation, migration and invasion in gallbladder carcinoma by targeting RAB22A

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