Lymph Node Ratio is an Important Prognostic Factor in Curatively Resected Gallbladder Carcinoma, Especially in Node-positive Patients: An Experience from Endemic Region in a Developing Country

Shah, Nehal; Qari, Hasina; Thau, Cao M; Burasakarn, Pipit; Mir, Abdul Wahid; Panday, B B

doi:10.5005/jp-journals-10018-1336

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…Studies describing the local landscape of cancer surgery burden, caseload, operative techniques, outcomes, and barriers are foundational to identifying key intervention targets and to evaluating change over time 15,16 . On a more “microscopic” level, recent studies highlighting differences in tumor pathology and epidemiology between settings have yielded important insights 17–21 . A study among Indian patients status‐post radical cholecystectomy for gallbladder carcinoma supported the utility of evaluating lymph node involvement for determining prognosis 19 .…”

Section: Resultsmentioning

confidence: 99%

“…On a more “microscopic” level, recent studies highlighting differences in tumor pathology and epidemiology between settings have yielded important insights 17–21 . A study among Indian patients status‐post radical cholecystectomy for gallbladder carcinoma supported the utility of evaluating lymph node involvement for determining prognosis 19 . Although some of the cancers investigated may be considered rare, these studies provide critical context for targeted design and informed assessment of effective local interventions.…”

Section: Resultsmentioning

confidence: 99%

“…15,16 On a more "microscopic" level, recent studies highlighting differences in tumor pathology and epidemiology between settings have yielded important insights. [17][18][19][20][21] A study among Indian patients status-post radical cholecystectomy for gallbladder carcinoma supported the utility of evaluating lymph node involvement for determining prognosis. 19 Although some of the cancers investigated may be considered rare, these studies provide critical context for targeted design and informed assessment of effective local interventions.…”

Section: Local Epidemiologic Studiesmentioning

confidence: 95%

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Global cancer surgery in low‐resource settings: A strengths, weaknesses, opportunities, and threats analysis

Sadler

Torio

Golby

2023

Cancer

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Global cancer surgery is an essential and complex component of oncologic care. This study aims to describe global cancer surgery literature since the 2015 Lancet Commission on Global Surgery and Cancer Surgery and perform a strengths, weaknesses, opportunities, and threats (SWOT) analysis. A systematic search was performed in PubMed of global cancer surgery articles. Themes were extracted from the included studies based on the following criteria: (1) performed in low‐ or low‐middle–income countries, (2) published during or after 2015, (3) published in peer‐reviewed journals, (4) written in the English language, and (5) accessible to the authors. Themes were further grouped into strengths, weaknesses, opportunities, and threats (SWOT analysis). The search strategy identified 154 articles published from 1992 to 2022. Forty‐six articles were included in the qualitative synthesis and SWOT analysis. Recurring themes included local epidemiologic studies, local innovations and feasibility studies, prioritizing quality of life outcomes, multidisciplinary team approaches, limited resources, health system gaps, lack of economic analyses, diverse cancer management strategies and priorities, inter‐setting collaboration, research expansion, the coronavirus disease 2019 pandemic, and unchecked technological advancements. These strengths, weaknesses, opportunities, and threats were described and related to the themes of research, surgical systems strengthening, economics and financing, and political framing of the 2015 Lancet Commission on Global Cancer Surgery. SWOT analyses of global cancer surgery may be helpful in suggesting future strategies for this expanding field. Plain language summary Cancer surgery is a resource‐intensive yet essential component of cancer care. In the face of projected growth of cancer burden, the present gap in cancer surgery care in low‐resource settings with stressed health care and surgical infrastructure risks further exacerbation. We present a strengths, weaknesses, opportunities, and threats analysis of recent global cancer surgery literature pertaining to low‐resource settings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Local Epidemiologic Studiesmentioning

confidence: 95%

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Global cancer surgery in low‐resource settings: A strengths, weaknesses, opportunities, and threats analysis

Sadler

Torio

Golby

2023

Cancer

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“…Long-term survival in these patients is still dependant on curative surgical resection. 1 Radical curative surgery has been shown to improve the survival of gallbladder carcinoma. 30 In locally advanced cancers (T3/T4 and nodal disease), to improve the survival, adjuvant chemotherapy after curative resection is a recommended treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

“…The only potential chance for survival is the radical surgery especially if patients are operated in the early stage. 1 , 2 The gallbladder carcinoma incidence is highest in Eastern parts of Europe, some parts of East Asia and Latin America. 3 As the gallbladder carcinoma incidence in the Western world is low, there is a difference in the treatment approach and no standard protocol is available for the management.…”

Section: Introductionmentioning

confidence: 99%

Neoadjuvant Chemotherapy for Advanced Gallbladder Cancer: Do We have Enough Evidence? A Systematic Review

Shah¹,

Qari²,

Thau³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

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A bstract Background Recently for advanced gallbladder carcinoma, neoadjuvant chemotherapy has emerged as an important strategy in place of adjuvant chemotherapy with the hope that it will help to improve the resectability and survival. Aim and objective The goal was to conduct a systematic review of published publications on the benefits of neoadjuvant chemotherapy for advanced gallbladder cancer treatment. Materials and methods This systematic review followed the Meta-analysis Of Observational Studies in Epidemiology standards. The clinical benefit rate of neoadjuvant chemotherapy, curative resectability rate, and R0 resection were the major outcomes of interest. The secondary outcomes of interest were overall and disease-free survival. Results Six published papers were included ( n = 420). One-hundred and twenty-eight cases (30.47%) despite receiving neoadjuvant chemotherapy had disease progression. Although 67.38% of patients (283 of 420) in this systematic review showed good response to the neoadjuvant chemotherapy, just 51.66% (217 of 420 cases) were operated, out of which only 171 cases were deemed to be feasible for surgical resection and had curative resection. Out of the cases that underwent curative surgery, 91.81% had R0 resection (157 out of 171 patients). The overall survival rate was found to be 18.5–50.1 months for patients in whom curative surgery was done and 5.0–10.8 months for nonsurgery patients. Conclusion No sufficient data exist to advocate the regular use of neoadjuvant chemotherapy in advanced gallbladder carcinoma, as data showed that only 1/3 of patients benefited and had a R0 resection. Further research should be the randomized controlled trials to further quantify the benefit of neoadjuvant chemotherapy in advanced gallbladder carcinoma. How to cite this article Naveed S, Qari H, Thau CM, et al . Neoadjuvant Chemotherapy for Advanced Gallbladder Cancer: Do We have Enough Evidence? A Systematic Review. Euroasian J Hepato-Gastroenterol 2021;11(2):87–94.

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Standardized lymph node dissection for gallbladder cancer under laparoscopy: en-bloc resection technique

Cheng

Liu

Dou

et al. 2023

Langenbecks Arch Surg

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Lymph Node Ratio is an Important Prognostic Factor in Curatively Resected Gallbladder Carcinoma, Especially in Node-positive Patients: An Experience from Endemic Region in a Developing Country

Cited by 4 publications

References 22 publications

Global cancer surgery in low‐resource settings: A strengths, weaknesses, opportunities, and threats analysis

Global cancer surgery in low‐resource settings: A strengths, weaknesses, opportunities, and threats analysis

Neoadjuvant Chemotherapy for Advanced Gallbladder Cancer: Do We have Enough Evidence? A Systematic Review

Standardized lymph node dissection for gallbladder cancer under laparoscopy: en-bloc resection technique

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