A reflectometric interferometric nanosensor for sarcosine

Di̇ltemi̇z, Sibel Emi̇r; Uslu, Okan

doi:10.1002/btpr.1955

Cited by 20 publications

(4 citation statements)

References 41 publications

(69 reference statements)

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“…Furthermore, researchers have explored the use of RIfS for creating specialized sensors. For example, a sarcosine-imprinted RIfS nanosensor was developed using the spin-coating technique, demonstrating excellent linearity with a correlation coefficient of 0.9622 and a detection limit of 45 nM [ 115 ]. Moreover, RIfS has been employed in immuno-sensing applications, as exemplified by a biosensor immobilizing anti-C-reactive protein (CRP) using protein A on an SiN chip [ 116 ].…”

Section: Diagnostic Toolsmentioning

confidence: 99%

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Thenuwara,

Curtin,

Tian

2023

Sensors

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Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by a “one-size-fits-all” paradigm, significantly restricting treatment efficacy. Despite the implementation of multimodal therapeutic strategies, survival rates remain disheartening. The conventional treatment approach, involving surgical resection, radiation, and chemotherapy, grapples with substantial limitations, particularly in addressing the invasive nature of gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), play pivotal roles in outlining tumor characteristics. However, they face limitations, such as poor biological specificity and challenges in distinguishing active tumor regions. The ongoing development of diagnostic tools and therapeutic approaches represents a multifaceted and promising frontier in the battle against this challenging brain tumor. The aim of this comprehensive review is to address recent advances in diagnostic tools and therapeutic approaches for gliomas. These innovations aim to minimize invasiveness while enabling the precise, multimodal targeting of localized gliomas. Researchers are actively developing new diagnostic tools, such as colorimetric techniques, electrochemical biosensors, optical coherence tomography, reflectometric interference spectroscopy, surface-enhanced Raman spectroscopy, and optical biosensors. These tools aim to regulate tumor progression and develop precise treatment methods for gliomas. Recent technological advancements, coupled with bioelectronic sensors, open avenues for new therapeutic modalities, minimizing invasiveness and enabling multimodal targeting with unprecedented precision. The next generation of multimodal therapeutic strategies holds potential for precision medicine, aiding the early detection and effective management of solid brain tumors. These innovations offer promise in adopting precision medicine methodologies, enabling early disease detection, and improving solid brain tumor management. This review comprehensively recognizes the critical role of pioneering therapeutic interventions, holding significant potential to revolutionize brain tumor therapeutics.

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Section: Diagnostic Toolsmentioning

confidence: 99%

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Thenuwara,

Curtin,

Tian

2023

Sensors

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“…On the other hand, another very important advantage of CE not mentioned above is the possibility of connecting it to various types of detector, mostly in a relatively simple way. A comparison of the main parameters of the detection techniques used and discussed below is summarized in Table .…”

Section: Detection Techniques Used With Capillary Electrophoresis‐basmentioning

confidence: 99%

Capillary electrophoresis‐based approaches for the study of affinity interactions combined with various sensitive and nontraditional detection techniques

2019

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Nearly all processes in living organisms are controlled and regulated by the synergy of many biomolecule interactions involving proteins, peptides, nucleic acids, nucleotides, saccharides, and small molecular weight ligands. There is growing interest in understanding them, not only for the purposes of interactomics as an essential part of system biology, but also in their further elucidation in disease pathology, diagnostics, and treatment. The necessity of detailed investigation of these interactions leads to the requirement of laboratory methods characterized by high efficiency and sensitivity. As a result, many instrumental approaches differing in their fundamental principles have been developed, including those based on capillary electrophoresis. Although capillary electrophoresis offers numerous advantages for such studies, it still has one serious limitation, its poor concentration sensitivity with the most commonly used detection method–ultraviolet‐visible spectrometry. However, coupling capillary electrophoresis with a more sensitive detector fulfils the above‐mentioned requirement. In this review, capillary electrophoresis combined with fluorescence, mass spectrometry, and several nontraditional detection techniques in affinity interaction studies are summarized and discussed, together with the possibility of conducting these measurements in microchip format.

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“…Sarcosine sensing has proven to be a valuable tool for assessing the treatment of PCa patients. Although established techniques like electrochemiluminescence [48] and gas chromatography‐mass spectrometry (GC‐MS) [49] exist for sarcosine determination, spectroscopy involving laborious sample processing, use of hazardous chemicals, high costs, and time‐consuming operations have prompted the need for developing a novel approach to sense sarcosine [29a] …”

Section: Introductionmentioning

confidence: 99%

Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

Chaudhari,

Patil,

Nangare

et al. 2024

ChemistrySelect

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Luminescent carbon nanoparticles, such as carbon quantum dots (CQDs) and graphene quantum dots (GQDs), are increasingly utilized for sarcosine detection due to their exceptional water permeability, sustained luminescence, and biocompatibility. Sarcosine as a biomarker holds significance for therapeutic purposes and disease identification. Carbon‐based sensors offer eco‐friendliness, recyclability, and affordability, making them sustainable for sensing applications across various domains. Despite the widespread use of standard sensors for sarcosine measurement, they face limitations. This paper presents a focused review of recent developments in biosensors utilizing luminescent carbon quantum dots and graphene quantum dots for sarcosine detection. Key processes are characterized by their selectivity and sensitivity to different forms of sarcosine and interfering substances like metallic ions and amino acids. The significant reaction mechanisms and detection methods for sarcosine are outlined and compared. Additionally, the challenges in developing functionalized CQDs and GQDs for further investigation are explored. In summary, luminescent carbon nanoparticles offer a promising avenue for sarcosine detection, addressing limitations of standard sensors through their cost‐effectiveness, sensitivity, and rapid response, thus holding potential for diverse sensing applications.

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A reflectometric interferometric nanosensor for sarcosine

Cited by 20 publications

References 41 publications

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review

Capillary electrophoresis‐based approaches for the study of affinity interactions combined with various sensitive and nontraditional detection techniques

Exploring the Significance of Carbon Quantum Dots and Graphene Quantum Dots in Sarcosine Sensing: A Key Biomarker for Prognosticating Prostate Cancer

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