A rare presentation of primary cutaneous basaloid squamous cell carcinoma of scalp

Javid, Mohamed; Swaminathan, Shanthi Ponnandai; Jebasingh, Arun Victor; Velayutham, Manivannan; Kawarat, Vikas

doi:10.18203/2349-2902.isj20182523

Cited by 4 publications

(6 citation statements)

References 4 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Primary cutaneous BSCC is a rare clinical entity with seven other cases reported and none of which resulted in brain metastasis. [2][3][4] BSCC portends a worse prognosis given the high propensity for lymph node and distal metastasis. 1 BSCC shows a strong correlation with oncogenic HPV strains, especially HPV16 in oropharyngeal and anogenital areas.…”

Section: Discussionmentioning

confidence: 99%

“…1 To date, seven cases of primary cutaneous BSCC outside the upper aerodigestive tract and mucosal genital regions have been reported. [2][3][4] Having BSCC portends a worse prognosis, as up to 75% of patients have advanced nodal or metastatic disease. 3 BSCC can metastasize to any organ, but brain metastasis rarely occurs.…”

Section: Introductionmentioning

confidence: 99%

“…3 BSCC can metastasize to any organ, but brain metastasis rarely occurs. [2][3][4] Human papillomavirus (HPV) infection upregulates the expression of p16 tumor suppressor in cells. 5,6 Oncogenic HPV16 is strongly associated with BSCC found in oropharyngeal and anogenital areas.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report

Soong

Hung

et al. 2020

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

Basaloid squamous cell carcinoma is an infiltrative and aggressive variant of squamous cell carcinoma with basaloid features. Primary skin-derived basaloid squamous cell carcinoma is rare. Basaloid squamous cell carcinoma is commonly observed in the oropharyngeal and anogenital regions and is associated with high-risk human papillomavirus. We report a case of primary basaloid squamous cell carcinoma overlying the right scapula with metastasis to the regional lymph nodes and brain despite surgical resection and adjuvant chemoradiation. Histopathologic investigations of high-risk cutaneous squamous cell carcinoma do not routinely involve human papillomavirus testing. In contrast, oncogenic human papillomavirus and p16 are screened in head and neck squamous cell carcinoma for prognostication. Since the patient presented with an aggressive variant of squamous cell carcinoma and distal metastasis despite standard therapies, human papillomavirus testing was performed. P16, a surrogate marker for human papillomavirus infection and specifically HPV16 was identified in the tumor. This is a unique report of HPV16 in primary cutaneous basaloid squamous cell carcinoma with distal brain metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report

Soong

Hung

et al. 2020

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

show abstract

“…In contrast to BCC, SCC is typically positive for cytokeratins and EMA but negative for BerEp4 and Bcl2. 18–20…”

Section: Diagnosismentioning

confidence: 99%

“…In contrast to BCC, SCC is typically positive for cytokeratins and EMA but negative for BerEp4 and Bcl2. [18][19][20] Histologic features of poorly differentiated SCC include immature cells, multiple mitotic figures, and scarce keratinization. P63 is highly sensitive in this diagnosis, 21,22 but this marker is also positive in BCC.…”

Section: Table 2 Associations With Metastatic Bccmentioning

confidence: 99%

Metastatic Basal Cell Carcinoma: An Unexpected Diagnosis in a Young Patient With Back Pain

Krooks

Wilhelm²,

Yassi³

et al. 2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Basal cell carcinoma (BCC) portends a notoriously favorable prognosis in most patients with morbidity limited to localized destruction and recurrence. Metastatic BCC (mBCC) is an unexpected outcome affecting less than 1% of patients with a known primary lesion and predominantly involves regional lymph nodes. Reports of isolated bone involvement and spinal cord compression are rare. In the cases we identified in the literature, patients presented with massive primary lesions on the trunk that had been present for years and that were often still present at the time of diagnosis. Additionally, histology of distant metastatic lesions typically reveals aggressive subtypes. Herein, we report a case of mBCC in a patient with a history of BCC involving the cheek; the lesion was excised more than 10 years ago. He was referred to our institution for acutely worsening back pain and multifocal neurologic deficits. Clinical symptoms and radiographic findings demonstrated isolated bone involvement, with multiple lytic bone lesions and spinal cord compression noted on imaging studies. Biopsy revealed nests of small basaloid cells with peripheral palisading and immunohistochemical staining consistent with the unexpected diagnosis of mBCC, nodular subtype. Our case illustrates that a historically resected primary lesion may cause distant metastasis after a decade and that nonaggressive subtypes can also be implicated. We also provide insight into the potential pathogenesis of this manifestation.

show abstract

An unusual case of pilonidal p16 positive squamous cell carcinoma—a case report

Khatri,

Chuang,

Swan

2024

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of squamous cell carcinoma. It is commonly seen in the oropharynx and strongly associated with p16-expressivity and high-risk human papilloma virus (HPV). We report the first case of primary cutaneous p16-positive BSCC in an elderly woman, with a background of chronic inverse psoriasis of the natal cleft. P16-expressivity is a common surrogate marker for oncogenic HPV16, routinely tested for oropharyngeal/anogenital squamous cell carcinoma. This is not routinely done for primary cutaneous disease. Pilonidal disease is uncommon in the elderly population, and malignant transformation is rarer still. Surgical resection is considered the mainstay of treatment for primary cutaneous BSCC, however due to this patient’s broad distribution of cutaneous field change and p16-expressivity, she was effectively treated with primary radiotherapy. This is a unique case of malignant transformation of pilonidal disease in an atypical demographic, with a rare/aggressive disease variant.

show abstract

A rare presentation of primary cutaneous basaloid squamous cell carcinoma of scalp

Cited by 4 publications

References 4 publications

Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report

Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report

Metastatic Basal Cell Carcinoma: An Unexpected Diagnosis in a Young Patient With Back Pain

An unusual case of pilonidal p16 positive squamous cell carcinoma—a case report

Contact Info

Product

Resources

About