Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report

Vu, Trang; Soong, Laura; Hung, Tawny; Fiorillo, Loretta; Joseph, Kurian

doi:10.1177/2050313x20935260

Cited by 4 publications

(6 citation statements)

References 10 publications

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“…Primary cutaneous p16-positive BSCC is a rare and aggressive malignancy. To date there have been eight cases reported in the literature, for which each patient had either nodal or distant metastases at time of diagnosis [ 3 , 5–7 ]. This is the first reported case of p16-positive BSCC of the natal cleft.…”

Section: Discussionmentioning

confidence: 99%

“…Oncogenic variants of HPV (oncogenes E6 and E7 in particular) inhibit tumor suppressors P53 and Rb, which facilitates unregulated cellular proliferation and tumorigenesis [ 2 ]. HPV-16 in particular is commonly found in anogenital/oropharyngeal BSCC [ 3 ]. HPV-related p16-positive cutaneous disease however is a rare clinical entity [ 4 ]; to date, there have been eight reported cases of cutaneous p16-positive BSCC [ 3 , 5–7 ].…”

Section: Introductionmentioning

confidence: 99%

“…HPV-16 in particular is commonly found in anogenital/oropharyngeal BSCC [ 3 ]. HPV-related p16-positive cutaneous disease however is a rare clinical entity [ 4 ]; to date, there have been eight reported cases of cutaneous p16-positive BSCC [ 3 , 5–7 ]. We present a unique case of p16-positive BSCC of the natal cleft which presents a unique clinical dilemma regarding the roles of surgery, chemoradiotherapy, and immunotherapy in a context other than anogenital/oropharyngeal disease.…”

Section: Introductionmentioning

confidence: 99%

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An unusual case of pilonidal p16 positive squamous cell carcinoma—a case report

Khatri,

Chuang,

Swan

2024

Journal of Surgical Case Reports

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Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of squamous cell carcinoma. It is commonly seen in the oropharynx and strongly associated with p16-expressivity and high-risk human papilloma virus (HPV). We report the first case of primary cutaneous p16-positive BSCC in an elderly woman, with a background of chronic inverse psoriasis of the natal cleft. P16-expressivity is a common surrogate marker for oncogenic HPV16, routinely tested for oropharyngeal/anogenital squamous cell carcinoma. This is not routinely done for primary cutaneous disease. Pilonidal disease is uncommon in the elderly population, and malignant transformation is rarer still. Surgical resection is considered the mainstay of treatment for primary cutaneous BSCC, however due to this patient’s broad distribution of cutaneous field change and p16-expressivity, she was effectively treated with primary radiotherapy. This is a unique case of malignant transformation of pilonidal disease in an atypical demographic, with a rare/aggressive disease variant.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An unusual case of pilonidal p16 positive squamous cell carcinoma—a case report

Khatri,

Chuang,

Swan

2024

Journal of Surgical Case Reports

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“…It should be checked whether the same also applies to the cigarette one. Limiting the number of oral sex partners, not smoking, and getting vaccinated against HPV are three strategies for reducing risk [ 50 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus: Current Knowledge and Focus on Oral Health

Fiorillo

Cervino

Surace³

et al. 2021

BioMed Research International

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The human papilloma virus (HPV) is responsible for different pathological manifestations in humans. This agent gives rise to lesions of different types and in different areas of the organism, including the oral cavity. The aim of this study is to show which are the main diseases for which HPV is responsible and to bring to light some of the interceptive and therapeutic strategies. The analysis was conducted by consulting the major scientific databases with the aim of obtaining information on the characteristics of oral HPV and its management; furthermore, the literature was supported by some clinical cases proposed by the authors. The role of dentistry is essential in the early diagnosis of this type of pathologies and above all in knowing how to direct patients towards a path that can lead to patient management, especially in the event that these lesions have a malignant potential. Enhancing the knowledge and role of dentistry can lead to early diagnosis of this type of injury, intercepting a pathology that could have multiorgan implications.

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“…Primarily found in the mucocutaneous and anogenital regions, BSCC is infrequently encountered as a primary skin malignancy. The existing literature has documented few instances of primary cutaneous BSCC (2)(3)(4)(5). We present here a case of primary cutaneous BSCC of the finger.…”

mentioning

confidence: 88%