A Rare Case of Breast Malignant Phyllodes Tumor With Metastases to the Kidney

Abstract

Phyllodes tumors are rare breast neoplasms. Surgery is the treatment of choice. The role of postoperative radiotherapy and chemotherapy is still under dispute, as there are no equivocal prognostic factors. Treatment failure results in the occurrence of distant metastasis—mainly to the lungs, bones, liver, and brain. We have described the case of a woman with a malignant phyllodes tumor of the breast that was surgically treated. She did not receive adjuvant therapy because there is no consensus on the role of postoperative chemotherapy and radiotherapy. One year following the surgery, the patient had left-sided nephrectomy performed because of a rapidly growing tumor of the kidney. Renal cancer was suspected; however, a histopathological examination revealed that it was a metastatic phyllodes tumor. At the same time, the patient was diagnosed as having metastases in the other kidney, the lungs, liver, and bones.Our case report describes not only an unusual localization of the metastases (in the kidneys), but also failure of the chemotherapy and the aggressive course of malignant phyllodes tumor. Identification of patients with high risk for distant metastasis and the introduction of uniform rules for the management of adjuvant chemotherapy and radiotherapy would make planning treatment as efficacious as possible.

Distant metastases in phyllodes tumours of the breast: an overview

“…Although the lungs and skeleton are the usual sites of distant metastasis for PT, almost all other organs have been shown to be afflicted, including the adrenal glands [17], brain [7, 9-11, 17, 18], gastrointestinal tract [17,[19][20][21], heart [22], kidney [23], liver [2,10,15,16,24,25], mesentery [26], pancreas and pleura [15], retroperitoneum [16], soft tissues [2,5,15,26,27], spleen and thyroid [19], tonsil [28], uterus [19], and vulva [29].…”

High-dose fulvestrant as third-line endocrine therapy for breast cancer metastasis to the left kidney

“…Another report described a patient with breast malignant phyllodes tumor and metastasis in the kidney. [ 16 ] In the context of invasive ductal carcinoma, 2 case reports are available in the literature. [ 17 , 18 ] The common symptoms of renal metastasis are flank pain and gross hematuria.…”

Atypical Distant Metastasis of Breast Malignant Phyllodes Tumors: A Case Report and Literature Review

“…One patient presented with a thyroid mass two years after a simple mastectomy for a MPT [ 29 ]. One case of left kidney metastasis has been reported [ 30 ] and one case of adrenal metastasis [ 31 ]. The last patient presented with thoracic vertebra and rib metastasis, as well as a pelvic mass [ 32 ].…”