High-dose fulvestrant as third-line endocrine therapy for breast cancer metastasis to the left kidney

Xia, Dandan; Wang, Huiyu; Wang, Runjie; Liu, Chaoying; Xu, Jiankun

doi:10.1097/md.0000000000011115

Cited by 1 publication

(2 citation statements)

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“…Mortality from breast cancer is associated with metastatic spread. The sites of metastasis vary, and the most common sites are lymph nodes, bone, lung, brain, and liver [ 2 ]. However, the number of breast cancer survivors increases with advances in diagnosis and treatment, the development of secondary malignancies and unusual metastatic patterns is being frequently recognized [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Microscopic metastases of primary breast cancer to the kidney are commonly found at autopsy with an incidence of 12.6% [ 4 ]. Yet clinically apparent renal metastasis from breast cancer is rare and there are several case reports describing the radiologic findings and symptoms of kidney metastasis from breast cancer [ 2 , 3 , 5 , 6 ]. In addition, to the best of our knowledge, there are no prior reports of kidney metastasis from breast cancer presenting with a thrombus in the inferior vena cava.…”

Section: Introductionmentioning

confidence: 99%

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Metastasis of breast cancer to the right kidney with a tumor thrombus in the inferior vena cava: a case report

et al. 2022

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Background It is quite rare for breast cancer to metastasize to the kidney with a tumor thrombus in the inferior vena cava. Case presentation A Japanese woman in her forties was diagnosed with cancer of the left breast and underwent left mastectomy with sentinel lymph node biopsy. The final pathological diagnosis was pT1aN0M0, stage IA (ER positive, PgR positive, HER2 negative). Thirteen years later, she presented for care with the complaint of abdominal pain. By imaging findings, right renal carcinoma with a tumor thrombus in the inferior vena cava and lung metastases was suspected. However, her tumors were refractory to molecular targeted therapy. In addition, CT-guided needle biopsy of the kidney and lung lesions was done and it was revealed that lesions of the left lung and the right kidney was breast cancer metastases (ER positive, PgR positive, HER2 negative). The patient started combination therapy consisting of abemaciclib, tamoxifen and leuprorelin. Six months later, she died from progression of her metastatic disease. Conclusions It is sometimes difficult to differentiate between primary renal cancer and kidney metastases from breast cancer on imaging. Renal biopsy is recommended before commencing treatment.

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Section: Introductionmentioning

confidence: 99%