A rapid synthetic method for organic polymer-based monoliths in a room temperature ionic liquid medium via microwave-assisted vinylization and polymerization

Shih, Yung‐Han; Singco, Brenda; Liu, Wanling; Hsu, Chao-Hsiang; Huang, Hsi‐Ya

doi:10.1039/c0gc00803f

Cited by 43 publications

(21 citation statements)

References 88 publications

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“…Previously our laboratory reported the manufacture of monolithic materials by microwave irradiation . This method significantly reduced vinylization and monolith synthesis from several hours for the conventional thermal heating to a few minutes by microwave.…”

Section: Performance Of the Proposed Microwave‐assisted Catecholaminementioning

confidence: 99%

Capillary electrophoresis‐laser‐induced fluorescence detection of rat brain catecholamines with microwave‐assisted derivatization

et al. 2012

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In this study, a rapid and sensitive method is described for the catecholamines detection in rat brain. CE with LIF detection for the determination of FITC derivatized catecholamines (dopamine, epinephrine, and norepinephrine) was demonstrated. Conventional water bath and microwave-assisted derivatization methods were employed and a significant reduction in the derivatization time from 2 h for the conventional water bath at room temperature (ca. 25°C) to 2 min for the microwave-assisted derivatization was achieved. Online sample concentration of field-amplified sample stacking (FASS) method was employed to achieve higher sensitivities (the detection limits obtained in the normal injection mode ranged from 2.6 to 4.5 ng L⁻¹ and in the FASS mode ranged from 22 to 34 pg L⁻¹). Furthermore, this microwave-assisted derivatization CE-LIF method successfully determined catecholamines in rat brain with as low as 100 ng L⁻¹ (FASS mode) to 10 μg L⁻¹ (normal injection mode). This CE-LIF method provided better detection ability when compared to the best reports on catecholamines analyses.

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Section: Performance Of the Proposed Microwave‐assisted Catecholaminementioning

confidence: 99%

Capillary electrophoresis‐laser‐induced fluorescence detection of rat brain catecholamines with microwave‐assisted derivatization

et al. 2012

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“…[7][8][9][10] One of the most valuable advantages of using microwave heating for chemical synthesis is the dramatic reduction in reaction time since microwave irradiation produces efficient internal heating by direct coupling of microwave energy with the molecules that are present in the reaction mixture. Very recently, similar work was published by Huang group, 11 and some typical organic polymer-based monolithic columns were prepared via microwave-assisted vinylization and polymerization, and evaluated comparatively by nano-HPLC and capillary electrochromatography (CEC). The goal of this work is to present a novel procedure for fast "mold preparation" of MIP fibers for SPME in batch reproducibly.…”

Section: Introductionmentioning

confidence: 96%

Rapid Preparation of Monolithic Molecular Imprinted Polymer Fiber for Solid Phase Microextraction by Microwave Irradiation

Jin

Chen

Liu

et al. 2013

J Chinese Chemical Soc

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In this paper, a simple, fast and in situ polymerization strategy to prepare monolithic molecularly imprinted polymer (MIP) fibers for solid phase microextraction (SPME) is developed using silica capillaries as molds. With the help of microwave irradiation, polymerization was carried out in 5.5 min using olivetol as a template molecular, a-methacrylic acid (MAA) as a functional monomer and ethylene dimethacrylate (EDMA) as a crosslinker, toluene and dodecanol as the binary porgens. The resulted MIP fibers were finally obtained after silica being etched away with a controlled length, and subsequently characterized by scanning electron microscope (SEM) and Fourier transform infrared absorption spectroscopy (FT-IR). Under the optimal extraction conditions, a simple method based on the coupling of MIP SPME with high performance liquid chromatography (HPLC) was used for the selective determination of the model mixtures of olivetol, phenol and m-toluidine in lake water and wheat bran samples. The recoveries of olivetol, phenol and m-toluidine for both samples were in the range of 87.3-93.6%, 21.4-27.2%, 18.9-24.8% at three spiked levels, respectively, demonstrating that higher extraction and the specific absorption occurred between the template molecule and the prepared MIP fiber.

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“…15,16 In this work, an ionic liquid (IL) was used as a porogen which was added into the polymerization solution to improve uniformity. 19,20 Recently, ILs have been more and more applied in the preparation of monoliths, which show more advantages than other kinds of reagents. 17,18 ILs have been widely used in the eld of analytical chemistry because of their unique physical and chemical properties.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a porous polymer monolithic column with an ionic liquid as a porogen and its applications for the separation of small molecules in high performance liquid chromatography

et al. 2015

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A novel porous polymer monolithic column was prepared by in situ free radical polymerization and used as a stationary phase for high performance liquid chromatography (HPLC). In this process, an ionic liquid (IL) was used as a porogen and reaction medium to create pores and enhance the flow-through properties of the polymer monoliths. The effect of IL in the polymerization mixture on the performance of the monoliths was studied in detail. The addition of IL can enhance the resolution and column efficiency compared to the monoliths with alcohol as the porogen. The chromatographic performance of the columns was demonstrated by the separation of various small molecules. The monolith exhibited a typical reversed phase chromatographic behavior with a column efficiency of 12 500 plates per m, which outperformed the commonly used porogen alcohol compounds. The results demonstrated that the IL was a potentially efficient porogen for the preparation of polymer monolithic columns. Moreover, the good mechanical stability, permeability, and reproducibility of column fabrication suggested that the proposed monolith can be expected to be an alternative tool for HPLC separation.

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A rapid synthetic method for organic polymer-based monoliths in a room temperature ionic liquid medium via microwave-assisted vinylization and polymerization

Cited by 43 publications

References 88 publications

Capillary electrophoresis‐laser‐induced fluorescence detection of rat brain catecholamines with microwave‐assisted derivatization

Capillary electrophoresis‐laser‐induced fluorescence detection of rat brain catecholamines with microwave‐assisted derivatization

Rapid Preparation of Monolithic Molecular Imprinted Polymer Fiber for Solid Phase Microextraction by Microwave Irradiation

Preparation of a porous polymer monolithic column with an ionic liquid as a porogen and its applications for the separation of small molecules in high performance liquid chromatography

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