A rapid radioimmunoassay for human placental lactogen

Saxena, B.N.; Refetoff, Samuel; Emerson, Kendall; Selenkow, Herbert A.

doi:10.1016/0002-9378(68)90269-x

Cited by 57 publications

(18 citation statements)

References 15 publications

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“…Placental lactogen has a biological activity similar to growth hormone and could thus be responsible for the raised plasma non-esterified fatty acid and reduced insulin sensitivity, and indeed for the increased responsiveness of the pancreatic islets to an insulinogenic stimulus (Kalkhoff et al 1964;Kalkhoff, Richardson, Beck & Stoddard, 1967). Levels of placental lactogen are consistently detectable after 6 weeks of gestation, rising progressively to reach a plateau after 34 weeks (Beck, Parker <fe Daughaday, 1965;Samaan, Yen, Friesen & Pearson, 1966;Spellacy, Carlson & Birk, 1966;Saxena, Refetoff, Emerson & Selenkow, 1968). Unlike growth hormone, the production of placental lactogen is unaffected by maternal exercise or ingestion of food.…”

Section: Plasma Insulin In Normal Pregnancymentioning

confidence: 99%

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

Baird¹

1969

Journal of Endocrinology

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Section: Plasma Insulin In Normal Pregnancymentioning

confidence: 99%

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

Baird¹

1969

Journal of Endocrinology

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“…This correlation and diagnostic reliability with respect to SGA has been confirmed [40,64,79,80,83,85]. Others found a relation to placen-'tal weight [5, 73,74] not confirmed by SCIARRA et al [75]. The great ränge of normal HPL levels in the last trimester has often been considered to limit the value and clinical use of this test [77,79].…”

Section: Resultsmentioning

confidence: 91%

Ultrasound and biochemical findings in intrauterine growth retardation

Kunz¹,

Keller²

1976

Journal of Perinatal Medicine

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The early recognition of fetal maldevelopment due to chronic placental insufficiency is of decisive importance if perinatal mortality and morbidity are to be further reduced. This can be achieved by direct and indirect methods, i.e. cephalometry and thoracometry using ultrasound on the one hand, and biochemical tests of the function of the fetoplacental unit, on the other. Estriol, pregnandiol and HPL levels and some placental enzymes are here of special interest. In this investigation an attempt was made to asses the diagnostic value of the various parameters and to suggest when they should be used. Jürg KUNZ, born 1942, Zürich, Studied medicine at University of Zürich, 1962-69 Curriculum vitae l Material and methodA total of 83 patients presently, or with a case history of risk hospitalised because of suspect placental insufficiency, was investigated. Twin pregnancies and those with doubtful duration were excluded. In the third trimester of pregnancy the following determinations were made: An average of 4 determinations of the biparietal head diameter using the B-scan method (Vidoson), 10 determinations of estriol and 3 of pregnandiol in urine [13,50] and 6 HPL determinations in the semm [49], 7 determinations of heat stable alkaline phosphatase (HSAP) [9], all per individual case. Biparietal head diameter values were transferred to a Standard curve that was in agreement with the one reported by HOLLÄNDER [42]. Growth retardation was assumed if the last two values showed the same trend with the date being certain and were below two Standard deviations or showed decreased progress. Biochemical parameters were considered to be pathological if they were below 95% of the normal values, with two values being outside this normal ränge or with 3 or more values being continuously below the 95% normal ränge. Maturity was assessed after birth from neurological and somatic signs of maturity according to D u BÖ-WITZ [25]. Infants were diagnosed äs small for date if their birth weight was below the lOth percentile on the LUBCHENKO curve [62]. ResultsFifteen of the 83 newborn were small for dates. Five had a gestational age of less than 37 weeks, 4 in the 35/36 week and one in the 30.5 week. A further 11 prematures was in the group of 68 normotrophic children. However, only 3 out of the 15 small for date infants were below the lower limit of the norm. The remaining 81 (98%) were within nonnal limits, 71 % below the curve for mean values. In twelve SGA infants the head diameter was normal prenatally and increased normally. Fig. 2 shows a very good correlation between weight percentile and the percentage deviation from the normal mean of estriol excretion. In all SGA cases values were found to be decreased. Ten were outside the 95% normal limits and 5 were still at least 40% below those limits. In infants with body weights between the lOth and 50 th percentile estriol values were below, the normal mean in 44%.Weight percentiles and HPL concentration in maternal serum ( Fig. 3) also correlated well. In 8 out of 15 SGA inf...

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“…avec la durée de la grossesse sans cependant trouver de relation entre les taux de celui-ci et le poids de l'enfant ou le poids du placenta. Saxena (1968) trouve une baisse assez nette des taux du H.P.L. en cas d'insuffisance placentaire et de souffrance foetale.…”

Section: Le Dosage De L ' Hormone Lactogène D 'Origine Placentaire Ouunclassified

“…Le H.P.L. est dosé par une méthode radio-immunologique rapide (Saxena, 1968), mais réservée à des laboratoires rompus à cette technique délicate. 60: 185-193 (1955 …”

Section: Le Dosage De L ' Hormone Lactogène D 'Origine Placentaire Ouunclassified

Le dosage des hormones dans l'insuffisance placentaire et le dépistage de la souffrance fœtale chronique

Engelhorn¹,

Šťastný²

1969

Gynecol Obstet Invest

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A rapid radioimmunoassay for human placental lactogen

Cited by 57 publications

References 15 publications

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

Ultrasound and biochemical findings in intrauterine growth retardation

Le dosage des hormones dans l'insuffisance placentaire et le dépistage de la souffrance fœtale chronique

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