A Rapid Method for the Determination of Griseofulvin in Fermenter Broth

Holbrook, A.; Bailey, F.; Bailey, Greta M.

doi:10.1111/j.2042-7158.1963.tb11222.x

Cited by 10 publications

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References 2 publications

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“…The culture was incubated on a rotatory shaker at 160 rev/min and 30°C. Samples were withdrawn at regular interval of 24 h and assayed for griseofulvin [14].…”

Section: Cultivation Medium and Culture Conditionsmentioning

confidence: 99%

Optimization of microbiological parameters for enhanced griseofulvin production using response surface methodology

Dasu

Panda

2000

Bioprocess Engineering

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Central composite design was used to determine the optimal levels of microbiological parameters, viz., slant age, seed age and inoculum level, for enhanced griseofulvin production by Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvum MTCC 2004 in shake¯ask fermentation. The optimal levels of slant age, seed age and inoculum level for Penicillium griseofulvum MTCC 1898 were found to be 8.8772 days, 4.2093 days, 12% (v/v) (º17.56 kg dry cell mass/m 3 ) and for Penicillium griseofulvum MTCC 2004, 8.221 days, 3.4875 days and 9% (v/v) (º8.09 kg dry cell mass/m 3 ) respectively. The yield of griseofulvin under optimal conditions was found to be 1.65 times for Penicillium griseofulvum MTCC 1898 and 1.07 times for Penicillium griseofulvum MTCC 2004 higher than that obtained using unoptimized conditions. The fermentation time for maximum production of griseofulvin by Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvum MTCC 2004 decreased by 4 days and 2 days respectively.

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“…The culture was incubated on a rotatory shaker at 160 rev/min and 30°C. Samples were withdrawn at regular interval of 24 h and assayed for griseofulvin [14].…”

Section: Cultivation Medium and Culture Conditionsmentioning

confidence: 99%