A chromatographic assay for the determination of griseofulvin is described, employing a hexane : methanol : chloroform : water partition system supported on Celite. Chromatographic separation is followed by ultra-violet measurement of the eluate fractions at 291 rnp.
A method has been devised for the determination of griseofulvin in fermenter broths. This is based on the conversion of griseofulvin to isogriseofulvin with methane sulphonic acid in methanol. The reaction is followed by measuring the resulting change in ultra‐violet absorption. The method is rapid, accurate and suited to the routine examination of a wide variety of samples.
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