Determination of griseofulvin by time-resolved phosphorimetry

McDuffie, J.R.; Neely, W. C.

doi:10.1016/0003-2697(73)90381-3

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…The assignments and energies of the excited states of GF, which are of major importance in considering the possibility of excitation energy transfer, have been previously reported by this laboratory (Neely and McDuffie, 1972;McDuffie and Neely, 1973) and were reconfirmed. In addition to the transitions at 320 nm (shoulder at 350 nm), 295 nm, and 236 nm, a smaller and previously unreported peak was also found at 210 nm.…”

Section: Electronic Energy Levelssupporting

confidence: 62%

Binding, Excitation Energy Transfer and Photosensitization in Griseofulvin‐dna Mixtures

Neely

Siraj

1988

Photochem & Photobiology

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The weak and reversible binding of the antifungal drug, griseofulvin (GF), to calf thymus DNA has been demonstrated by difference spectroscopy and the quenching of the fluorescence of G F by DNA observed. The value of K , was determined to be 800 M." by fluorescence quenching titration.Adenosine and guanosine also exhibit difference spectra with G F and quench G F fluorescence indicating that they may be the site of both binding and energy transfer. The in vitro photosensitization of DNA by griseofulvin is shown to occur. It is proposed that the clinically observed in vivo photosensitizing action of griseofulvin may result from binding followed by excitation energy transfer and that this may also be important in the antifungal activity of the drug.

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Section: Electronic Energy Levelssupporting

confidence: 62%

Binding, Excitation Energy Transfer and Photosensitization in Griseofulvin‐dna Mixtures

Neely

Siraj

1988

Photochem & Photobiology

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“…Antibiotics containing amino sugars, such as kanamycin and polyoxin, were assayed by reaction with pyridoxal and zinc ion in pyridine-methanol solution to yield highly fluorescent zinc chelates of iV-pyridoxylidenes (559). Griseofulvin was determined in mixtures with dechlorogriseofulvin, by means of time-resolved phosphorimetry (587), and a detailed study of its luminescence characteristics was reported (641). Luminescence spectra of actinomycin antibiotics in the fungal cultures were found to differ from those in organic solvents (707).…”

Section: )mentioning

confidence: 99%

Fluorometric analysis

Weissler¹

1974

Anal. Chem.

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This review is dedicated to the memory of Prof. Charles E. White, who was at first the sole author and then the senior author of the 13 previous biennial reviews in this series. He was a leader in establishing the value and importance of fluorescence analysis; he was also a good and warm-hearted person, whose death in May 1973 was a real loss.were found to be very sensitive fluorescence reagents for detection of Zn, Al, Sc, Ga, and In, as well as suitable for quantitation of, for example, Zn at pH 6.9-7.2 in 80% EtOH (845). Acridine fluorescence quenching by iodine was proposed for the indirect determination of Au, Cr, Se,

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PMR assay of natural products in pharmaceuticals-III Assay of griseofulvin

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Hassan

1980

Talanta

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Determination of griseofulvin by time-resolved phosphorimetry

Cited by 6 publications

References 12 publications

Binding, Excitation Energy Transfer and Photosensitization in Griseofulvin‐dna Mixtures

Binding, Excitation Energy Transfer and Photosensitization in Griseofulvin‐dna Mixtures

Fluorometric analysis

PMR assay of natural products in pharmaceuticals-III Assay of griseofulvin

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