A Randomized Trial of High Dose Bolus Metoclopramide Versus Low-Dose Continuous Infusion Metoclopramide in the Prevention of Cisplatin-Induced Emesis

Risk of extrapyramidal side effects comparing continuous vs. bolus intravenous metoclopramide administration: a systematic review and meta‐analysis of randomised controlled trials

“…In the BG, doses were: 2 mg/kg metoclopramide (Dana et al . , Agostinucci et al . ), 20 mg metoclopramide (Egerton‐Warburton & Povey ), 1 mg/kg metoclopramide (Navari , Mori et al .…”

“…Most studies collected the sample size in terms of number of patients studied (ranging from 9–154 patients), and only one study collected the number of neoplastic treatment per patients, in which the authors compared the efficacy of metoclopramide in 32 courses of chemotherapy of 16 patients (Dana et al . ).…”

“…Some additional drugs were used to prevent or to mitigate undesirable effects on the study carried out: (1) three studies used diphenhydramine and dexamethasone (Dana et al . , Agostinucci et al . , Saito et al .…”

“…, Dana et al . ), visual analogue scales of sedation and nausea (Warrington et al . ) and Prince Henry Akathisia Rating Scale (PHARS) (Thaker ) which is a validated tool for assessment of akathisia, the scale has objective and subjective components rated between 0–3; from absent to severe, respectively (Parlak et al .…”

Advances in the Management of Cytotoxic Drug-Induced Nausea and Vomiting

“…In these trials, 8/21 (38,,) of patients given metoclopramide were free from nausea and vomiting but none of the patients given prochlorperazine or placebo were symptom free. A number of studies have assessed the efficacy of high-dose metoclopramide administered as a continuous infusion (29)(30)(31)(32). This method of administration has a number of proposed advantages: rapid attainment and maintenance of therapeutic serum concentrations and prevention of drug accumulation (reduced toxicity).…”