Risk of extrapyramidal side effects comparing continuous vs. bolus intravenous metoclopramide administration: a systematic review and meta‐analysis of randomised controlled trials

Abstract

Continuous infusion is an effective intervention to reduce in patients discomfort caused by the extrapyramidal side effects of metoclopramide. Clinicians also reduce the time spent on alleviating these unwanted effects.

Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors

“…The invention of novel small molecules that are both potent and selective antitumor agents continues to be a serious challenge to medicinal chemistry researchers (Zhong et al, 2014;Iyer, 2015;Lin et al, 2019). In spite of the indispensable advances accomplished over the last decades in the design and development of assorted anticancer agents, current accessible treatments still have two significant limitations, the primary being the shortage of selectivity for cancer tissues (Shafei et al, 2017), inflicting unwanted side effects (Cavero-Redondo et al, 2015;Brewer et al, 2016;Decalf et al, 2017). The second is the acquisition of multiple-drug resistance by cancer cells, rendering them unresponsive to standard therapy (Wu et al, 2014).…”

Efeito extrapiramidal induzido por metaclopramida e outros santidopaminérgicos e antipsicóticos e uso de biperideno na reversão do quadro/Extrapyramidal effect induced by metaclopramide and other antidopaminergics and antipsychotics and use of biperidene in the reversal of the frame

“…Além dos efeitos adversos relacionados ao sistema motor, pacientes com síndrome extrapiramidal induzida por metoclopramida podem apresentar desordens como ansiedade, depressão maior, psicose, síndrome de Tourette e síndrome das pernas inquietas. Devido a essas alterações, que podem envolver transtornos ansiosos e de humor, o diagnóstico diferencial da síndrome extrapiramidal é complexo e muitas vezes não realizado ou realizado de maneira equivocada pelos próprios profissionais da saúde (REDONDO et al, 2015). No entanto, Kirkpatrick, Sogawa e Cleves (2020), apontam que a metoclopramida é amplamente utilizada para dor de cabeça aguda em crianças, porém não é tão observado na pratica.…”

“…Em um estudo realizado por Redondo et al, (2015), percebeu-se que ao comparar o efeito da administração em bolus, infusão intravenosa contínua de metoclopramida, estas produzem menos efeitos colaterais extrapiramidais em 8% (IC 95%,5-11%). Algumas pesquisas, a exemplo de As benzodiazepinas não interferem no equilíbrio dos neurotransmissores, atuando através da indução de um relaxamento muscular e da sedação com alívio dos sintomas enquanto o fármaco é metabolizado.…”

Metoclopramide‐induced acute dystonic reactions in the horse

“…A continuous rate infusion of metoclopramide would not result in peaks and troughs in plasma concentration and may be safer than injections administered intermittently, although the evidence for this based on studies of human patients is not strong (Cavero‐Redondo et al . ). This author also wonders, as do Agass et al .…”

“…over 15 min. A continuous rate infusion of metoclopramide would not result in peaks and troughs in plasma concentration and may be safer than injections administered intermittently, although the evidence for this based on studies of human patients is not strong (Cavero-Redondo et al 2015). This author also wonders, as do Agass et al (2017), if this filly was more prone to developing CNS problems because it appeared to be agitated before metoclopramide was administered and had a history of unpredictable behaviour.…”