Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood

Phillips, Bob; Gopaul, Shireen; Gibson, Faith; Houghton, Elizabeth; Craig, Jean; Light, Kate; Pizer, Barry

doi:10.1002/14651858.cd007786.pub2

Cited by 45 publications

(48 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The recommendation for the use of a 5-HT3 antagonist plus a corticosteroid for prevention of acute AINV in children receiving HEC is also supported by a meta-analysis which observed that the addition of a corticosteroid to a 5-HT3 antagonist resulted in a relative risk (RR) of complete control of vomiting of 2.03 (95% CI: 1.35, 3.04) [18]. The source guideline [12] recommends palonosetron plus dexamethasone for adults about to receive MEC.…”

Section: What Pharmacological Interventions Provide Optimal Control Omentioning

confidence: 92%

Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients

Dupuis

Boodhan

Holdsworth

et al. 2013

Pediatric Blood & Cancer

121

163

View full text Add to dashboard Cite

This guideline provides an approach to the prevention of acute antineoplastic‐induced nausea and vomiting (AINV) in children. It was developed by an international, inter‐professional panel using AGREE and CAN‐IMPLEMENT methods. Evidence‐based interventions that provide optimal AINV control in children receiving antineoplastic agents of high, moderate, low, and minimal emetogenicity are recommended. Recommendations are also made regarding selection of antiemetic agents for children who are unable to receive corticosteroids for AINV control, the role of aprepitant and optimal doses of antiemetic agents. Gaps in the evidence used to support the recommendations were identified. The contribution of this guideline to AINV control in children requires prospective evaluation. Pediatr Blood Cancer 2013; 60: 1073–1082. © 2013 Wiley Periodicals, Inc.

show abstract

Section: What Pharmacological Interventions Provide Optimal Control Omentioning

confidence: 92%

Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients

Dupuis

Boodhan

Holdsworth

et al. 2013

Pediatric Blood & Cancer

121

163

View full text Add to dashboard Cite

show abstract

“…[123] CINV is a very disturbing issue for children with cancer. They are more prone to vomiting than adults.…”

Section: Discussionmentioning

confidence: 99%

“…Despite this treatment, more than 40% of patients still vomit in response to highly emetogenic chemotherapy. [34] New antiemetic agents such as neurokinin 1 receptor inhibitor, aprepitant, have been reported to improve control of emesis in adults. But, it is not yet established for pediatric use.…”

Section: Introductionmentioning

confidence: 99%

Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children

Emir

Erturgut

Vidinlisan

2013

Indian Journal of Medical and Paediatric Oncology

View full text Add to dashboard Cite

Background:Chemotherapy induced nausea and vomiting (CINV) is one of the most disturbing side-effects in children receiving highly emetogenic chemotherapy. We aimed to assess whether the addition of an antiemetic cocktail containing midazolam and diphenhydramine to granisetron plus dexamethasone combination could ameliorate CINV in this study.Patients and Methods:A total of 23 children aged between 1 and 16 years to receive cisplatin containing chemotherapy in our clinic were included in this study from April 2007 to April 2008. 76 cycles in 23 patients were randomly assigned to receive either antiemetic regimen 1 or antiemetic regimen 2. Antiemetic regimen 1 containing granisetron 0, 04 mg/kg plus dexamethasone 0, 2 mg/kg were given in 45 chemotherapy cycles. In 31 cycles, an antiemetic cocktail containing midazolam 0, 04 mg/kg, diphenhyramine 2, 5 mg/-kg in addition to granisetron plus dexamethasone was given. Number of vomiting, severity of nausea, the use of rescue therapy and adverse events were assessed between day 1 and day 5.Results:Complete response for the acute phase was observed 38/45 (84, 4%) cycles in regimen 1 as compared with 28/31 (90, 3%) in regimen 2, antiemetic cocktail regimen (P > 0.05). Complete response for delayed emesis after 24 h of the beginning of chemotherapy was observed in 29/45 (64, 4 %) in regimen 1 and 16/31 (51, 6%) in regimen 2. Antiemetic cocktail was not superior to the granisetron plus dexamethasone combination in controlling emesis in acute and delayed phase. Furthermore, patients receiving antiemetic regimen 2 were noted significantly more side effects.Conclusion:Our data showed that antiemetic cocktail containing midazolam and diphenhydramine was not better in controlling acute and delayed emesis. A slightly more toxicity with additional drugs was also observed.

show abstract

“…Since these early studies, physicians and nurses have worked side by side to better define, measure, and control not only vomiting, but also the equally unpleasant side effect, nausea 48,49. These efforts have led to valid measurement tools and multi-agent antiemetic regimens that minimize the impact of nausea and vomiting on QOL during childhood cancer treatment 50–52…”

Section: Supportive and Palliative Carementioning

confidence: 99%

Multidisciplinary care in pediatric oncology

Cantrell¹,

Ruble²

2011

JMDH

View full text Add to dashboard Cite

This paper describes the significant advances in the treatment of childhood cancer and supportive care that have occurred over the last several decades and details how these advances have led to improved survival and quality of life (QOL) for children with cancer through a multidisciplinary approach to care. Advances in the basic sciences, general medicine, cooperative research protocols, and policy guidelines have influenced and guided the multidisciplinary approach in pediatric oncology care across the spectrum from diagnosis through long-term survival. Two case studies are provided to highlight the nature and scope of multidisciplinary care in pediatric oncology care.

show abstract

Antiemetic medication for prevention and treatment of chemotherapy induced nausea and vomiting in childhood

Cited by 45 publications

References 80 publications

Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients

Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients

Comparison of granisetron plus dexamethasone versus an antiemetic cocktail containing midazolam and diphenhydramine for chemotherapy induced nausea and vomiting in children

Multidisciplinary care in pediatric oncology

Contact Info

Product

Resources

About