ylie and her mother had just landed from Madrid. Exhausted from the long-haul flight, they drove their rental car straight from the airport to the hospital, arriving in the same leggings and layers that they had put on forty-eight hours earlier. * Their clothing revealed the geography of Kylie's clinical trajectory: Kylie's proud Seahawks sweatshirt reflected her many months spent at Seattle Children's Hospital just after diagnosis, and her mother's cowboy boots divulged Kylie's time at St. Jude Hospital. Souvenirs from Los Angeles and Spain were packed in the six purple roller suitcases they wheeled into the hospital room with them; they had been on the move, away from home, for more than a year. Kylie had been diagnosed with Stage IV osteosarcoma at age 6-about 19 months prior to our (A.S.P.) first encounter. At the time of diagnosis, she had a primary large mass in her left distal femur and three lung metastases. Beyond the unwanted though expected port infections and pancytopenia, roadblocks dotted her clinical course: severe mucositis, multiple episodes of sepsis, repeated transfusions, renal insufficiency, and relapse. Just prior to our initial meeting, while at a complementary medicine center in Spain, she developed severe headaches localized to her left temple and a watery, red right eye. Her family and clinicians feared what MRI and PET-CT confirmed: Kylie's sarcoma had relapsed for a second time with a recurrent periorbital mass. Kylie's mother made plans to rush back to the States for Kylie to restart chemotherapy immediately on a Phase I/II clinical trial. Energized on hour one of my night shift as a pediatrics intern at a midwestern tertiary care hospital, I entered Kylie's room expecting to move quickly through the usual processes of admission: history, physical exam, admission orders, medication reconciliation, and communication with the Pediatric Hematology Oncology team about chemotherapy plans. When I got to medication reconciliation, the process came to a halt. As Kylie's mother unzipped the largest roller suitcase, she began pulling out bottle after bottle of medications labeled with names I did not recognize. The institute they had visited in Spain recommended a non-formulary probiotic, several vitamin combinations, and a handful of other herbal supplements.