A randomized study of the safety and efficacy of fondaparinux versus placebo in the prevention of venous thromboembolism after coronary artery bypass graft surgery

Kolluri, Raghu; Plessa, Anna L.; Sanders, Mark C.; Singh, Nilanchali; Lucore, Charles L.

doi:10.1016/j.ahj.2015.10.013

Cited by 13 publications

(8 citation statements)

References 22 publications

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“…Summary of the evidence. Our systematic search for RCTs identified 3 studies 70,381,382 that fulfilled our inclusion criteria and measured outcomes relevant to this context. Because of the paucity of RCTs, we also systematically searched for observational studies and identified 1 additional study that fulfilled our inclusion criteria.…”

Section: Recommendation 25mentioning

confidence: 99%

“…383 One trial reported the effect of pharmacological prophylaxis vs no intervention on risk of mortality. 381 Two trials reported the effect on the risk of symptomatic PEs and on the risk of any proximal and distal DVTs. 70,381,382 The effect on the risk of major bleeding was reported from an RCT 381 and a nonrandomized controlled study.…”

Section: Recommendation 25mentioning

confidence: 99%

“…381 Two trials reported the effect on the risk of symptomatic PEs and on the risk of any proximal and distal DVTs. 70,381,382 The effect on the risk of major bleeding was reported from an RCT 381 and a nonrandomized controlled study. 383 Surgery-specific baseline risk estimates were obtained from a systematic review and meta-analysis of risk of VTE after cardiac surgery.…”

Section: Recommendation 25mentioning

confidence: 99%

“…384 Harms and burdens. Based on 1 large observational study 383 and supported by a single relevant RCT, 381 the rates of major bleeding may be increased with pharmacological prophylaxis (RR, 1.26; 95% CI, 1.07-1.47; low certainty in the evidence of effects). This corresponds to 4 more (1-6 more) major bleeds per 1000 patients.…”

Section: Recommendation 25mentioning

confidence: 99%

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American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

et al. 2019

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Background:Venous thromboembolism (VTE) is a common source of perioperative morbidity and mortality.Objective:These evidence-based guidelines from the American Society of Hematology (ASH) intend to support decision making about preventing VTE in patients undergoing surgery.Methods:ASH formed a multidisciplinary guideline panel balanced to minimize bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline-development process, including performing systematic reviews. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess evidence and make recommendations, which were subject to public comment.Results:The panel agreed on 30 recommendations, including for major surgery in general (n = 8), orthopedic surgery (n = 7), major general surgery (n = 3), major neurosurgical procedures (n = 2), urological surgery (n = 4), cardiac surgery and major vascular surgery (n = 2), major trauma (n = 2), and major gynecological surgery (n = 2).Conclusions:For patients undergoing major surgery in general, the panel made conditional recommendations for mechanical prophylaxis over no prophylaxis, for pneumatic compression prophylaxis over graduated compression stockings, and against inferior vena cava filters. In patients undergoing total hip or total knee arthroplasty, conditional recommendations included using either aspirin or anticoagulants, as well as for a direct oral anticoagulant over low-molecular-weight heparin (LMWH). For major general surgery, the panel suggested pharmacological prophylaxis over no prophylaxis, using LMWH or unfractionated heparin. For major neurosurgery, transurethral resection of the prostate, or radical prostatectomy, the panel suggested against pharmacological prophylaxis. For major trauma surgery or major gynecological surgery, the panel suggested pharmacological prophylaxis over no prophylaxis.

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Section: Recommendation 25mentioning

confidence: 99%

Section: Recommendation 25mentioning

confidence: 99%

Section: Recommendation 25mentioning

confidence: 99%

Section: Recommendation 25mentioning

confidence: 99%

See 2 more Smart Citations

American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

et al. 2019

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“…Moreover studies examining the efficacy and risk profile of anticoagulants as prophylaxis in cardiac surgery are generally limited. A cohort study by Kulik and coworkers 12 and a placebo-controlled randomized trial by Kolluri and associates 13 both found no benefit for chemical prophylaxis but were limited by lack of statistical power. Given the existing knowledge gap the present study attempted to characterize the national incidence, mortality, and costs associated with DVT and PE after coronary artery bypass grafting (CABG) and valve operations.…”

mentioning

confidence: 99%

Deep Venous Thrombosis and Pulmonary Embolism in Cardiac Surgical Patients

Khoury

Lyons

Sanaiha

et al. 2020

The Annals of Thoracic Surgery

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Pentasaccharides for the prevention of venous thromboembolism

Dong

Song

et al. 2016

Cochrane Database of Systematic Reviews

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Analysis 2.3. Comparison 2 Fondaparinux versus placebo sensitivity analysis inserting Yokote 2011, Outcome 3 total DVT......... Analysis 2.4. Comparison 2 Fondaparinux versus placebo sensitivity analysis inserting Yokote 2011, Outcome 4 proximal DVT..... Analysis 2.5. Comparison 2 Fondaparinux versus placebo sensitivity analysis inserting Yokote 2011, Outcome 5 total PE........... Analysis 2.6. Comparison 2 Fondaparinux versus placebo sensitivity analysis inserting Yokote 2011, Outcome 6 fatal PE........... Analysis 2.7. Comparison 2 Fondaparinux versus placebo sensitivity analysis inserting Yokote 2011, Outcome 7 non-fatal PE...... Analysis 2.8. Comparison 2 Fondaparinux versus placebo sensitivity analysis inserting Yokote 2011, Outcome 8 major bleeding.

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A randomized study of the safety and efficacy of fondaparinux versus placebo in the prevention of venous thromboembolism after coronary artery bypass graft surgery

Cited by 13 publications

References 22 publications

American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

Deep Venous Thrombosis and Pulmonary Embolism in Cardiac Surgical Patients

Pentasaccharides for the prevention of venous thromboembolism

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