Deep-vein thrombosis can be ruled out in a patient who is judged clinically unlikely to have deep-vein thrombosis and who has a negative D-dimer test. Ultrasound testing can be safely omitted in such patients.

Managing patients for suspected pulmonary embolism on the basis of pretest probability and D -dimer result is safe and decreases the need for diagnostic imaging.

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Patients with a first episode of idiopathic venous thromboembolism should be treated with anticoagulant agents for longer than three months.

Management of patients with suspected pulmonary embolism on the basis of pretest probability and results of ventilation-perfusion scanning is safe.

Low-molecular-weight heparin can be used safely and effectively to treat patients with proximal deep-vein thrombosis at home.

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