A randomized, single‐blind comparison of topical clindamycin + benzoyl peroxide (Duac^®) and erythromycin + zinc acetate (Zineryt^®) in the treatment of mild to moderate facial acne vulgaris

Abstract

CDP + BPO and ERY + Zn are effective treatments for acne but CDP + BPO has an earlier onset of action that should improve patient compliance.

Topical clindamycin in the management of acne vulgaris

“…Topical clindamycin appeared to work as well as or superior to oral tetracycline or minocycline [17,[62][63][64][65][66] , topical tetracycline [67] , topical benzoyl peroxide [72] and topical erythromycin with/without zinc [67][68][69][70][71]74,75] .…”

“…Bioavailability from a 1% foam formulation was similar to or less than that from a 1% gel formulation [47] . Tables 2, 3 , and 4 illustrate English language clinical trial data for open or clindamycin-/vehicle-controlled trials [16,[47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] , monotherapy versus non-clindamycin monotherapy trials [17,[62][63][64][65][66][67][68][69][70][71][72][73] , and monotherapy versus combination therapy trials [39,[74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92...…”

An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders

“…In a randomized, single-blinded clinical trial, Langner et al compared the efficacy of topical clindamycin+benzoyl peroxide (Duac) and topical erythromycin+Zn acetate (Zineryt) in the treatment of mild to moderate facial AV. They observed that clindamycin+benzoyl peroxide had an earlier onset of action with a faster significant reduction in the total lesion counts than erythromycin+Zn acetate [43]. In another study, Heffernan et al assessed the efficacy of picolinic acid gel, a Zn finger therapy, in the treatment of acne.…”

Modern Methods of Acne Treatment in Children

“…Moreover, single application of the drug a day was more convenient for patients and promoted better adherence to the treatment. Both variants of therapy demonstrated high level of safety [14]. Systemic antibacterial therapy remains the main method of treating moderate and severe acne in children.…”

“…Along with higher efficacy and considerable inflammation reduction, according to the common scale of statistical appraisal (Investigator's Static Global Assessment, ISGA), safety of using combined therapy was the same as the safety of benzoyl peroxide monotherapy. In their trial, A. Langner et al compared efficacy of combined local therapy at mild and moderate face acne; in the first case it involved 1% clindamycin and 5% benzoyl peroxide, in the second -4% erythromycin and 1.2% zinc acetate [14]. 72 patients had been receiving treatment with the first combination of drugs OD for 3 months; 75 patients -with the second combination of drugs BID for 3 months.…”