2007
DOI: 10.1517/14656566.8.15.2625
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Topical clindamycin in the management of acne vulgaris

Abstract: A small cadre of antimicrobials are commonly used and regarded as effective and safe, as systemic and topical treatments of acne vulgaris. These include oral tetracycline, doxycycline, minocycline and topical clindamycin and erythromycin. Topical antimicrobials work via both antimicrobial and non-antimicrobial mechanisms: the former due to suppression of the growth of propionibacterial species (especially Propionibacterium acnes and P. granulosum). Clindamycin appears to be superior in efficacy compared with e… Show more

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Cited by 32 publications
(21 citation statements)
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“…Fourth, CL should likely rarely be used alone given its relatively inferior performance and the issue of antibiotic resistance. 8 Lastly, formulation has effects on product performance, as all studies using BPO 1 SA used the same solubilized BPO formulation and outperformed other products at the early end points.…”
Section: Discussionmentioning
confidence: 99%
“…Fourth, CL should likely rarely be used alone given its relatively inferior performance and the issue of antibiotic resistance. 8 Lastly, formulation has effects on product performance, as all studies using BPO 1 SA used the same solubilized BPO formulation and outperformed other products at the early end points.…”
Section: Discussionmentioning
confidence: 99%
“…Topical antibiotics have a direct anti‐inflammatory action and can also reduce the perifollicular lymphocytes involved in comedogenesis 18,31,32 . The substantial increase in resistant strains of P. acnes and other bacteria to clindamycin and erythromycin 33 means that these agents are not recommended as monotherapy for adult female acne, in patients who have received many previous topical antibiotic treatments 34 . The use of topical antibiotics in combination therapy should only be continued until no further clinical improvement is observed 34 …”
Section: Adult Female Acne Therapymentioning
confidence: 99%
“…One of the pathogenic factors of acne is P. acnes [22,23]. Topical antibacterial agents are an essential element of the armamentarium for the treatment of acne vulgaris [24,25]. As P. acnes , a potential pathogenic agent of acne, is extremely sensitive to TauBr, we hypothesized that TauBr may be a good candidate for the topical therapy for acne vulgaris, without the risk of inducing bacterial resistance [26,27].…”
Section: Introductionmentioning
confidence: 99%