A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-α 2 expression in endometriosis women

Khodarahmian, Mahshad; Amidi, Fardin; Moini, Ashraf; Kashani, Ladan; Salahi, Elham; Danaii-mehrabad, Shahla; Nashtaei, Maryam Shabani; Mojtahedi, Maryam Farid; Esfandyari, Sahar; Sobhani, Aligholi

doi:10.1016/j.jri.2020.103248

Cited by 40 publications

(42 citation statements)

References 42 publications

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“…Moreover, it reduced the levels of vascular endothelial growth factor (VEGF) in endometrial tissue, which is efficient for endometriosis therapy [ 150 ]. A randomized exploratory trial in infertile patients with endometriosis (stage III–IV) within the window of implantation revealed that receiving resveratrol (400 mg) for 12–14 weeks significantly attenuated the levels of VEGF and TNF-α genes and protein in the ectopic endometrium compared with the placebo group [ 151 ]. Several studies have reported that sulforaphane (SFN), an isothiocyanate in cruciferous vegetables such as cauliflower, cabbage, and broccoli, has antioxidative, antitumor, anti-inflammatory, and immune-enhancing effects [ 152 , 153 ].…”

Section: Endometriosismentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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Diet and nutrition are fundamental in maintaining the general health of populations, including women’s health. Health status can be affected by nutrient deficiency and vice versa. Gene–nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to diseases, including cancer, through several mechanisms. Gynecological diseases in general are diseases involving the female reproductive system and include benign and malignant tumors, infections, and endocrine diseases. Benign diseases such as uterine fibroids and endometriosis are common, with a negative impact on women’s quality of life, while malignant tumors are among the most common cause of death in the recent years. In this comprehensive review article, a bibliographic search was performed for retrieving information about nutrients and how their deficiencies can be associated with gynecological diseases, namely polycystic ovary syndrome, infertility, uterine fibroids, endometriosis, dysmenorrhea, and infections, as well as cervical, endometrial, and ovarian cancers. Moreover, we discussed the potential beneficial impact of promising natural compounds and dietary supplements on alleviating these significant diseases.

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Section: Endometriosismentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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“…The results from biopsy samples showed that intervention with resveratrol (400 mg, twice a day) for 12-14 weeks led to a significant decrease of these genes' expression. The same group applying the same experimental design and doses, most likely using the same set of samples, subsequently found that intervention with resveratrol resulted in decreased VEGF and TNF-α mRNA as well as protein expression levels in the eutopic endometrium [79]. Thus, the majority of clinical studies tend to support that resveratrol can relieve the endometriotic symptoms by inhibiting the expression of key angiogenic and inflammatory factors in endometriotic tissues.…”

Section: Findings From Human Populationmentioning

confidence: 96%

Phytoestrogens for the Management of Endometriosis: Findings and Issues

et al. 2021

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Endometriosis, a chronic disease characterized by recurrent pelvic pain and infertility, severely impacts the health and life quality of many women worldwide. Since phytoestrogens are commonly found in a variety of foods, and estrogen is a major pathological factor for the pathogenesis of endometriosis, their possible involvement cannot be ignored. This review summarizes data on the relationship between phytoestrogen intake and endometriosis risk, and analyzes the findings from in vitro experiments, rodent endometriotic models, and human intervention trials. While favorable results were often obtained from endometrial primary cultures and animal models for resveratrol, isoflavones and puerarin, only resveratrol showed promising results in human intervention trials. Critical issues concerning the current study efforts are discussed: the possible reasons beneath the discrepant observations of estrogenic/anti-estrogenic effects by phytoestrogens; the complicated interplays between phytoestrogens and endogenous estrogens; the shortage of currently used animal models; the necessity to apply reasonable doses of phytoestrogens in experiments. It is expected that the analyses would help to more properly assess the phytoestrogens’ effects on the endometriosis pathogenesis and their potential values for preventive or therapeutic applications.

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“…The distribution of endometrial cells usually involves the pelvic peritoneum, the ovaries, and the uterosacral and broad ligaments. Its severe symptoms are usually pelvic pain and infertility [ 95 , 96 , 97 ]. Considerably, endometriosis involves approximately 6-10% of all women in the world and is recurrent and refractory because of its hormone-dependence.…”

Section: Exosomes In the Pathophysiology Of Female Reproductionmentioning

confidence: 99%

Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy

Esfandyari

Elkafas

Chugh

et al. 2021

IJMS

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Cell–cell communication is an essential mechanism for the maintenance and development of various organs, including the female reproductive system. Today, it is well-known that the function of the female reproductive system and successful pregnancy are related to appropriate follicular growth, oogenesis, implantation, embryo development, and proper fertilization, dependent on the main regulators of cellular crosstalk, exosomes. During exosome synthesis, selective packaging of different factors into these vesicles happens within the originating cells. Therefore, exosomes contain both genetic and proteomic data that could be applied as biomarkers or therapeutic targets in pregnancy-associated disorders or placental functions. In this context, the present review aims to compile information about the potential exosomes with key molecular cargos that are dysregulated in female reproductive diseases which lead to infertility, including polycystic ovary syndrome (PCOS), premature ovarian failure (POF), Asherman syndrome, endometriosis, endometrial cancer, cervical cancer, ovarian cancer, and preeclampsia, as well as signaling pathways related to the regulation of the reproductive system and pregnancy outcome during these pathological conditions. This review might help us realize the etiology of reproductive dysfunction and improve the early diagnosis and treatment of the related complications.

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A randomized exploratory trial to assess the effects of resveratrol on VEGF and TNF-α 2 expression in endometriosis women

Cited by 40 publications

References 42 publications

Nutrition in Gynecological Diseases: Current Perspectives

Nutrition in Gynecological Diseases: Current Perspectives

Phytoestrogens for the Management of Endometriosis: Findings and Issues

Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy

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