Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy

Esfandyari, Sahar; Elkafas, Hoda; Chugh, Rishi Man; Park, Hang-Soo; Navarro, Antònia; Al-Hendy, Ayman

doi:10.3390/ijms22042165

Cited by 83 publications

(65 citation statements)

References 233 publications

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“…In addition, miR-526b regulates the expression of matrix metalloproteinase-1 and hypoxiainducible factor 1-alpha. Finally, miR-1269 controls the expression of the FOXO1 gene as a critical factor in endometrial stromal decidualization and the implantation process [232].…”

Section: Exosomes In the Early Detection Of Pregnancy Complicationsmentioning

confidence: 99%

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

et al. 2021

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Exosomes are extracellular vesicles released by cells, both constitutively and after cell activation, and are present in different types of biological fluid. Exosomes are involved in the pathogenesis of diseases, such as cancer, neurodegenerative diseases, pregnancy disorders and cardiovascular diseases, and have emerged as potential non-invasive biomarkers for the detection, prognosis and therapeutics of a myriad of diseases. In this review, we describe recent advances related to the regulatory mechanisms of exosome biogenesis, release and molecular composition, as well as their role in health and disease, and their potential use as disease biomarkers and therapeutic targets. In addition, the advantages and disadvantages of their main isolation methods, characterization and cargo analysis, as well as the experimental methods used for exosome-mediated drug delivery, are discussed. Finally, we present potential perspectives for the use of exosomes in future clinical practice.

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Section: Exosomes In the Early Detection Of Pregnancy Complicationsmentioning

confidence: 99%

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

et al. 2021

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“…Furthermore, new, emerging biomarkers have been discovered in the fields of genomics and proteomics, like exosomes, which are involved in the cellular cross-talks and related biological processes [16]. Nutrigenomics [17,18], epigenomics [19] and nutriepigenomics [20,21] investigate how dietary habits and nutrition, as well as environmental factors, and their complex, non-linear interactions can finely modulate the human genome and its expression, and impact on human diseases, including gynecological conditions.…”

Section: Gynecology and Omics Datamentioning

confidence: 99%

Gynecology Meets Big Data in the Disruptive Innovation Medical Era: State-of-Art and Future Prospects

Khamisy‐Farah

Furstenau

Kong

et al. 2021

IJERPH

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Tremendous scientific and technological achievements have been revolutionizing the current medical era, changing the way in which physicians practice their profession and deliver healthcare provisions. This is due to the convergence of various advancements related to digitalization and the use of information and communication technologies (ICTs)—ranging from the internet of things (IoT) and the internet of medical things (IoMT) to the fields of robotics, virtual and augmented reality, and massively parallel and cloud computing. Further progress has been made in the fields of addictive manufacturing and three-dimensional (3D) printing, sophisticated statistical tools such as big data visualization and analytics (BDVA) and artificial intelligence (AI), the use of mobile and smartphone applications (apps), remote monitoring and wearable sensors, and e-learning, among others. Within this new conceptual framework, big data represents a massive set of data characterized by different properties and features. These can be categorized both from a quantitative and qualitative standpoint, and include data generated from wet-lab and microarrays (molecular big data), databases and registries (clinical/computational big data), imaging techniques (such as radiomics, imaging big data) and web searches (the so-called infodemiology, digital big data). The present review aims to show how big and smart data can revolutionize gynecology by shedding light on female reproductive health, both in terms of physiology and pathophysiology. More specifically, they appear to have potential uses in the field of gynecology to increase its accuracy and precision, stratify patients, provide opportunities for personalized treatment options rather than delivering a package of “one-size-fits-it-all” healthcare management provisions, and enhance its effectiveness at each stage (health promotion, prevention, diagnosis, prognosis, and therapeutics).

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“…The structures contain protein, DNA, RNA, and/or miRNA of the cells that secrete them. Exosomes have been used as biomarkers in different reproductive diseases [145][146][147][148][149][150][151].…”

Section: Exosomesmentioning

confidence: 99%

“…Wu and coworkers [149] analyzed the miRNA in samples from patients with varying types of endometriosis to understand the regulation of different pathways. They then were able to explore the most relevant miRNA in endometriosis [148][149][150]. This information is critical since directed therapies depending on endometriosis may provide new elements to control the inflammatory disease and aid in fertilization [148][149][150][151][152][153][154][155][156][157][158][159][160][161][162][163][164][165][166].…”

Section: Exosomesmentioning

confidence: 99%

“…The use of endosomes for therapy has raised the interest of several groups in recent years [145][146][147][148][149]. In addition, the experience with other disease has provided new tools for generating individual and targeted analysis to decrease the inflammatory response and provide the critical tissue milieu for implantation and pregnancy [145][146][147][148][149][150][151].…”

Section: Exosomesmentioning

confidence: 99%

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A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Garmendia

Sanctis

2021

Immuno

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NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions. In the endometrium, NK cell populations vary depending on age, hormones, and inflammation. When pregnancy occurs, tissue-resident NK cells and conventional NK cells are recruited to protect the fetus, a tolerogenic response. On the contrary, in the inflamed endometrium, various inflammatory cells down-regulate NK tolerance and impair embryo implantation. Therefore, NK cells’ pharmacological modulation is difficult to achieve. Several strategies have been used, from progesterone, lipid emulsions to steroids; the success has not been as expected. However, new therapeutic approaches have been proposed to decrease the endometrial inflammatory burden and increase pregnancy success based on understanding NK cell physiology.

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Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy

Cited by 83 publications

References 233 publications

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

Gynecology Meets Big Data in the Disruptive Innovation Medical Era: State-of-Art and Future Prospects

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

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