A randomized, double-blind trial of bromocriptine efficacy in nonfluent aphasia after stroke

Abstract

The authors assessed the efficacy of bromocriptine in nonfluent aphasia after stroke in a 16-week, randomized, double-blind, placebo-controlled clinical trial conducted from June 2002 to April 2004. In all 38 patients after 4 months of treatment, improvement in both the bromocriptine and placebo treatment groups was observed (p < 0.001). The analysis of repeated-measures analysis of variance revealed bromocriptine did not improve nonfluent aphasia.

Current Evidence for Post Stroke Aphasia Treatment

“…It was reported to have beneficial effects in single case and case series studies. However, there was no significant difference compared to placebo in a randomized controlled trial that was published in [15]. A single dose of levodopa (100 mg) administered before every session of language training improved verbal fluency and repetition better than placebo group in post-stroke patients with frontal lobe damage.…”

Pharmacotherapy to Improve the Acquired Aphasia following Brain Damages: A Review Study

“…Among all, bromocriptine agonist of postsynaptic dopamine D2 receptor has been investigated more than others (7,21,23 Ramezani S, et al that the type of aphasia (22,23), the cause of aphasia (98), the treatment plan (99) and dose of medication (100) play a vital role in outcome. Bromocriptine functions on mesocortical dopaminergic neurons which project from mesencephalon to dorsal caudate nucleus of basal gangalia, supplementary motor area (SMA) and anterior cingulum (101).…”

“…Much effort have been put on aphasia pharmacotherapy in past half century particularly revealing conflicting results on dopaminergic agonists. Dopaminergic drugs if taken along with aphasia therapy would be effective in patients with mild to moderate fluent aphasia, though not expected in other conditions (7,(21)(22)(23)(24). The recent two decades has seen accelerated developments in neuroscience research in favor of pharmacotherapy to improve the language deficits (8).…”

The ‘Standard’ for Poststroke Aphasia Recovery

“…Существуют некоторые доказательства в поддержку этой точки зрения [2][3][4][5][6][7][8]. Другие исследователи высказывают предположение, что некоторые лекарственные препараты, такие как ингибиторы холинэстеразы, декстроамфетамин, кофе-ин [9][10][11][12][13][14], или дополнительные методы воздействия -транскраниальная магнитная стимуляция [15] или прямая стимуляция коры головного мозга [16] -могут усиливать эффективность логопедической терапии. Простым способом демонстрации дополнительных преимуществ этих вмешательств является построение графика улучшений показателей у лиц, получавших вспомогательное лечение параллельно с графиком, который R.M.…”