A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder

Mello, Marcelo Feijó de; Yeh, Mary Sau Ling; Neto, Jair Barbosa; Braga, Luciana Lorens; Fiks, Jose Paulo; Mendes, Daniela Deise; Moriyama, Tais; Valente, Nina Leão Marques; Costa, Mariana Caddrobi Pupo; Mattos, Patricia Ferreira; Bressan, Rodrigo A.; Andreoli, Sérgio Baxter; Mari, Jair de Jesus

doi:10.1186/1471-244x-9-28

Cited by 12 publications

(6 citation statements)

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“…Total-I and Total-C of the Nanai people showed significantly strong correlations but were not identical, which was in good accordance with a previous report [28]. However, both seemed to be high compared with previous reports [22][23][24]26]. The ethnic minority status of the Nanai may increase the likelihood of adverse outcomes [13][14][15].…”

Section: Discussionsupporting

confidence: 84%

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Posttraumatic stress disorders in the Nanai after pollution of the Amur River: ethnocultural analysis

Korshunova

Katsuyama

Demura

et al. 2013

Environ Health Prev Med

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Section: Discussionsupporting

confidence: 84%

“…Estimation of total severity scores was performed by summing the frequency and intensity ratings with Total-C ranging from 0 to 136. Total-C was classified as follows: subclinical = 0-19, mild = 20-39, moderate = 40-59, severe = 60-79, and extremely severe C80 [26].…”

Section: Caps (Russian Language Certified Version)mentioning

confidence: 99%

Posttraumatic stress disorders in the Nanai after pollution of the Amur River: ethnocultural analysis

Korshunova

Katsuyama

Demura

et al. 2013

Environ Health Prev Med

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“…Due to an expected refusal rate of 20%, and in order to increase the likelihood of identifying post-traumatic stress disorder cases, the three strata with the highest homicide rates were oversampled, resulting in 1500 interviews. In Sao Paulo, we expected to identify approximately 120 current cases to be referred to a case-control study [23] and to a clinical trial [24] on post-traumatic stress disorder (PTSD). As we expected a 5% one-year prevalence of PTSD, we decided to increase the sample size to 3,000 interviews to allow for the identification of the required PTSD cases.…”

Section: Methodsmentioning

confidence: 99%

The Impact of Epidemic Violence on the Prevalence of Psychiatric Disorders in Sao Paulo and Rio de Janeiro, Brazil

et al. 2013

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BackgroundViolence and other traumatic events, as well as psychiatric disorders are frequent in developing countries, but there are few population studies to show the actual impact of traumatic events in the psychiatric morbidity in low and middle-income countries (LMIC).AimsTo study the relationship between traumatic events and prevalence of mental disorders in São Paulo and Rio de Janeiro, Brazil.MethodsCross-sectional survey carried out in 2007–2008 with a probabilistic representative sample of 15- to 75-year-old residents in Sao Paulo and Rio de Janeiro, Brazil, using the Composite International Diagnostic Interview.ResultsThe sample comprised 3744 interviews. Nearly 90% of participants faced lifetime traumatic events. Lifetime prevalence of any disorders was 44% in Sao Paulo and 42.1% in Rio de Janeiro. One-year estimates were 32.5% and 31.2%. One-year prevalence of traumatic events was higher in Rio de Janeiro than Sao Paulo (35.1 vs. 21.7; p<0.001). Participants from Rio de Janeiro were less likely to have alcohol dependence (OR = 0.55; p = 0.027), depression (OR = 0.6; p = 0.006) generalized anxiety (OR = 0.59; p = 0.021) and post-traumatic stress disorder (OR = 0.62; p = 0.027). Traumatic events correlated with all diagnoses – e.g. assaultive violence with alcohol dependence (OR = 5.7; p<0.001) and with depression (OR = 1.7; p = 0.001).ConclusionOur findings show that psychiatric disorders and traumatic events, especially violence, are extremely common in Sao Paulo and Rio de Janeiro, supporting the idea that neuropsychiatric disorders and external causes have become a major public health priority, as they are amongst the leading causes of burden of disease in low and middle-income countries. The comparison between the two cities regarding patterns of violence and psychiatric morbidity suggests that environmental factors may buffer the negative impacts of traumatic events. Identifying such factors might guide the implementation of interventions to improve mental health and quality of life in LMIC urban centers.

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“…Several cutoff points have been reported as follows: for Total-I, scores ≥25 indicate persons at high risk of PTSD [ 15 , 16 ] and scores ≥34 indicate probable or confirmed PTSD cases [ 15 , 16 ]; additionally, for Total-C, scores of 20–39 indicate mild PTSD [ 17 ] and scores of 40–59 indicate moderate PTSD [ 17 ]. To separate the participants into four groups, cutoff scores of 34 (for the Total-I) and 40 (for the Total-C) were used as cutoffs in the present study; individuals with low Total-I scores (<34) and low Total-C scores (<40) were categorized into the LL group; those with low Total-I scores (<34) and high Total-C scores (≥40) were categorized into the LH group; those with high Total-I scores (≥34) and low Total-C scores (<40) were categorized into the HL group, and those with high Total-I scores (≥34) and high Total-C scores (≥40) were categorized into the HH group.…”

Section: Methodsmentioning

confidence: 99%

Association between posttraumatic stress disorder (PTSD) severity and ego structure of the Nanai people

Ota¹,

Korshunova²,

Demura³

et al. 2017

Environ Health Prev Med

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BackgroundA man-made chemical disaster occurred in the Amur River, leading to posttraumatic stress disorder (PTSD) in the Nanai people indigenous to the river’s surrounding area. PTSD severity measured by the total scores of Impact of Event Scale-Revised (IES-R) (Total-I) and Clinician-Administered PTSD Scale (CAPS) (Total-C) were not always identical in terms of demographic and ethnocultural characters. It is possible that the results derived using the Total-I and Total-C may differ for persons with different backgrounds and/or individual characteristics. In this study, the associations between PTSD severity and personal characteristics were evaluated.MethodsThe study was a field-type survey including 187 randomly selected participants (75 males and 112 females). In addition to Total-I/Total-C, scores for each IES-R/CAPS item, Intrusion, Avoidance, and Hyperarousal, and Ego Structure Test by Ammon (ISTA) score were examined to evaluate their personal characteristics.ResultsNo specific trends in ISTA score were obvious among four groups defined according to Total-I/Total-C. The results of principal component analysis showed that all IES-R/CAPS items contributed positively to the 1st axis but to the 2nd axis in a different manner. ISTA items did not always show correlations to each other, but principal component analysis suggested that Construct contributed positively and Destruct and Deficient (with the exception of Destruct sexuality) contributed negatively. High IES-R scores were associated with Construct Aggression and Deficient Inner demarcation, but high CAPS score was less likely to exhibit Construct Narcissism.ConclusionTo avoid the misdiagnosis of PTSD, usage of both IES-R/CAPS may be required. Simultaneous application of personality/ego tests may be helpful, but appropriate numbers of their questions would be important.

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A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder

Cited by 12 publications

References 34 publications

Posttraumatic stress disorders in the Nanai after pollution of the Amur River: ethnocultural analysis

Posttraumatic stress disorders in the Nanai after pollution of the Amur River: ethnocultural analysis

The Impact of Epidemic Violence on the Prevalence of Psychiatric Disorders in Sao Paulo and Rio de Janeiro, Brazil

Association between posttraumatic stress disorder (PTSD) severity and ego structure of the Nanai people

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