A randomized controlled trial of a standard 4-week protocol of repetitive transcranial magnetic stimulation in severe treatment resistant depression

Eijndhoven, Philip van; Bartholomeus, Joey; Möbius, Martin; Bruijn, A. de; Ferrari, Gina R. A.; Mulders, Peter; Schene, Aart H.; Schutter, Dennis J.L.G.; Spijker, Jan; Tendolkar, Indira

doi:10.1016/j.jad.2020.05.055

Cited by 10 publications

(20 citation statements)

References 22 publications

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“…In most studies (n = 7), the stimulation was conducted with a Magstim Super Rapid stimulator system [ 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Four studies also applied the MagProX-100 or R30 stimulator [ 35 , 49 , 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…The brain site for rTMS application employed by the studies ranged from the left PFC (n = 5) [ 42 , 46 , 49 , 50 , 53 ] to the left DLPFC (n = 4) [ 35 , 48 , 52 , 56 ]. Four studies indicated DLPFC without specifying either the left or right [ 45 , 47 , 51 , 55 ], with one study evaluating the difference in effectiveness between the left and right DLPFC [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

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Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Adu

Shalaby

Chue

et al. 2022

Behavioral Sciences

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Treatment-resistant depression (TRD) is associated with significant disability, and due to its high prevalence, it results in a substantive socio-economic burden at a global level. TRD is the inability to accomplish and/or achieve remission after an adequate trial of antidepressant treatments. Studies comparing repetitive transcranial magnetic stimulation (rTMS) with electroconvulsive therapy (ECT) and pharmacotherapy have revealed evidence of the therapeutic efficacy of rTMS in TRD. These findings suggest a crucial role for rTMS in the management of TRD. This article aims to conduct a comprehensive scoping review of the current literature concerning the use of rTMS and its therapeutic efficacy as a treatment modality for TRD. PubMed, PsycINFO, Medline, Embase, and Cinahl were used to identify important articles on rTMS for TRD. The search strategy was limited to English articles within the last five years of data publication. Articles were included if they reported on a completed randomized controlled trial (RCT) of rTMS intervention for TRD. The exclusion criteria involved studies with rTMS for the treatment of conditions other than TRD, and study and experimental protocols of rTMS on TRD. In total, 17 studies were eligible for inclusion in this review. The search strategy spanned studies published in the last five years, to the date of the data search (14 February 2022). The regional breakdown of the extracted studies was North American (n = 9), European (n = 5), Asian (n = 2) and Australian (n = 1). The applied frequencies of rTMS ranged from 5 Hz to 50 Hz, with stimulation intensities ranging from 80% MT to 120% MT. Overall, 16 out of the 17 studies suggested that rTMS treatment was effective, safe and tolerated in TRD. For patients with TRD, rTMS appears to provide significant benefits through the reduction of depressive symptoms, and while there is progressive evidence in support of the same, more research is needed in order to define standardized protocols of rTMS application in terms of localization, frequency, intensity, and pulse parameters.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Adu

Shalaby

Chue

et al. 2022

Behavioral Sciences

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“…Furthermore, this indicates that the interactions of neuronal oscillations across multiple frequencies between theta‐alpha amplitude modulation frequency and rhythms could be a potentially pivotal EEG predictive biomarker for the antidepressant effect for monitoring the antidepressant effect of piTBS in the early treatment session, that is, first 2 weeks. Previous studies generally applied 4–6 weeks rTMS treatment as a standard protocol (Blumberger et al, 2018; van Eijndhoven et al, 2020). From the EEG patterns of theta‐alpha amplitude modulation frequency changes after 2 week's treatment in the present study, the NonResponder did not show the entrainment aftereffects by piTBS, which is clearly dissociated from Responder.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, our previous studies have shown that prolonged iTBS (piTBS; 1,800 pulses), which is three times longer than the standard iTBS protocol, as well as 10 Hz rTMS had more effective antidepressant efficacy than a sham condition following a 2‐week treatment session (Li et al, 2014, 2020). In addition, a large double‐blind, sham‐controlled study has demonstrated that the responders who received rTMS showed primary enhancement during the first 2 weeks (O'Reardon et al, 2007), although previous studies used 4–6 weeks rTMS treatment as a standard protocol (Blumberger et al, 2018; van Eijndhoven et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Critical role of rhythms in prefrontal transcranial magnetic stimulation for depression: A randomized sham‐controlled study

Tsai

Liang

et al. 2021

Human Brain Mapping

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Repetitive transcranial magnetic stimulation (rTMS) is an alternative treatment for depression, but the neural correlates of the treatment are currently inconclusive, which might be a limit of conventional analytical methods. The present study aimed to investigate the neurophysiological evidence and potential biomarkers for rTMS and intermittent theta burst stimulation (iTBS) treatment. A total of 61 treatment‐resistant depression patients were randomly assigned to receive prolonged iTBS (piTBS; N = 19), 10 Hz rTMS (N = 20), or sham stimulation (N = 22). Each participant went through a treatment phase with resting state electroencephalography (EEG) recordings before and after the treatment phase. The aftereffects of stimulation showed that theta‐alpha amplitude modulation frequency (fam) was associated with piTBS_Responder, which involves repetitive bursts delivered in the theta frequency range, whereas alpha carrier frequency (fc) was related to 10 Hz rTMS, which uses alpha rhythmic stimulation. In addition, theta‐alpha amplitude modulation frequency was positively correlated with piTBS antidepressant efficacy, whereas the alpha frequency was not associated with the 10 Hz rTMS clinical outcome. The present study showed that TMS stimulation effects might be lasting, with changes of brain oscillations associated with the delivered frequency. Additionally, theta‐alpha amplitude modulation frequency may be as a function of the degree of recovery in TRD with piTBS treatment and also a potential EEG‐based predictor of antidepressant efficacy of piTBS in the early treatment stage, that is, first 2 weeks.

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“…近年来, rTMS 被越来越多地应用到抑郁症、创伤后应激障碍、运动障碍和慢性疼痛等疾病的治疗中 (Blades et al, 2020;Brys et al, 2016;van Eijndhoven et al, 2020;Nardon et al, 2017;Perera et al, 2016)。事实上, 以往研究也表明, rTMS 对包括工作记忆 (Beynel et al, 2019;Yang et al, 2019)、语言 (Zhao et al, 2017;Myczkowski et al, 2018) 以及决策 (Rahnev et al, 2016;Guillaume et al, 2018)在内的多项认知功能具有改善作用, Cotelli et al, 2012;Marra et al, 2015) (Anderkova et al, 2015;Eliasova et al, 2014)…”

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Effects of repetitive transcranial magnetic stimulation on patients with mild cognitive impairment

Chen¹,

He²,

Yang³

et al. 2021

Adv Psychol Sci

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Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia, and there is no high-quality evidence that supports the pharmacologic treatment of MCI. Repetitive transcranial magnetic stimulation (rTMS) can improve the whole brain function by eliciting changes in synaptic plasticity. In this systematic review, the effectiveness and neural mechanisms of rTMS enhance MCI patients were analyzed. Future studies should optimize the localization for TMS, extend the period of the intervention effect evaluation, and explore how rTMS works in the treatment of MCI combining with neuroimaging technologies.

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A randomized controlled trial of a standard 4-week protocol of repetitive transcranial magnetic stimulation in severe treatment resistant depression

Cited by 10 publications

References 22 publications

Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review

Critical role of rhythms in prefrontal transcranial magnetic stimulation for depression: A randomized sham‐controlled study

Effects of repetitive transcranial magnetic stimulation on patients with mild cognitive impairment

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