A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health

Eberhard, Jörg; Ruiz, Kate; Tan, Jian; Jayasinghe, Thilini N.; Khan, Shahrukh; Eroğlu, Elif İnan; Adler, Christina; Simpson, Stephen J.; Couteur, David G. Le; Raubenheimer, David; Macia, Laurence; Gosby, Alison K.; Ribeiro, Rosilene V

doi:10.1111/jcpe.13587

Cited by 12 publications

(13 citation statements)

References 53 publications

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“…A cross-sectional study conducted in Denmark suggested an inverse relationship between casein and whey protein intake and periodontitis in adults [ 171 ]. Additionally, a randomised controlled study demonstrated that a higher-fat, semi-vegetarian diet is protective against clinical parameters of periodontitis in healthy adults aged 65–75 years [ 172 ]. In a cross-sectional study, vegetarians aged ~40 years had smaller pocket depth, and less bleeding on probing, compared to non-vegetarians [ 173 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Intake and Oral Health in Older Adults—A Narrative Review

et al. 2022

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Oral health is vital to general health and well-being for all ages, and as with other chronic conditions, oral health problems increase with age. There is a bi-directional link between nutrition and oral health, in that nutrition affects the health of oral tissues and saliva, and the health of the mouth may affect the foods consumed. Evidence suggests that a healthy diet generally has a positive impact on oral health in older adults. Although studies examining the direct link between oral health and protein intake in older adults are limited, some have explored the relationship via malnutrition, which is also prevalent among older adults. Protein–energy malnutrition (PEM) may be associated with poor oral health, dental caries, enamel hypoplasia, and salivary gland atrophy. This narrative review presents the theoretical evidence on the impact of dietary protein and amino acid composition on oral health, and their combined impact on overall health in older adults.

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Section: Discussionmentioning

confidence: 99%

Protein Intake and Oral Health in Older Adults—A Narrative Review

et al. 2022

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“…There is substantial evidence supporting a strong association between periodontitis and micronutrient intake [49][50][51][52][53][54][55]. Varied studies have been conducted in different directions to evaluate the association between periodontitis and micronutrient intake [45,[56][57][58][59][60]. Existing studies tend to explore the correlation using linear models, showing that associations between micronutrient intake and some other diseases were complex and nonlinear [61][62][63][64][65][66][67].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Micronutrient Intake Is Associated with the Risk of Periodontitis: A Dose–response Association Study Based on NHANES 2009–2014

Shang

Yang

et al. 2022

Nutrients

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The association between micronutrient intake and the risk of periodontitis has received much attention in recent years. However, most studies focused on the linear relationship between them. This study aimed to explore the dose–response association between micronutrient intake and periodontitis. A total of 8959 participants who underwent a periodontal examination, and reported their micronutrient intake levels were derived from the US National Health and Nutrition Examination Survey (NHANES, 2009–2014) database. Logistic regression was performed to evaluate associations between micronutrient intake and periodontitis after propensity score matching (PSM), and restricted cubic splines (RCS) analysis was conducted to explore the dose–response associations. Following PSM, 5530 participants were included in the RCS analysis. The risk of periodontitis was reduced with sufficient intake of the following micronutrients: vitamin A, vitamin B1, vitamin B2, and vitamin E. In addition, the risk of periodontitis was increased with excessive intake of the following micronutrients: vitamin B1 (1.8 mg/day, males; 1.3 mg/day, females), vitamin C (90 mg/day, males), and copper (1.1 mg/day, combined). In conclusion, a linear association was found between vitamin A, vitamin B2, vitamin C, and copper and periodontitis—namely, a sufficient intake of vitamin A and vitamin B2 might help reduce the prevalence of periodontitis; by contrast, a high intake of vitamin C and copper increased the risk. In addition, a nonlinear dose–response association was found for the incidence of periodontitis with vitamin B1 and vitamin E. When within reasonable limits, supplemental intake helped reduce the prevalence of periodontitis, while excessive intake did not help significantly and might even increase the risk. However, confounding factors, such as health awareness, should still be considered.

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“…Persons who maintained a normal weight, performed the recommended level of exercise, and ate a high-quality diet were 40% less likely to have periodontitis than those who did not engage in any of these health-promoting behaviors [ 154 ]. Regarding the dietary content, a study in which subjects consumed four experimental diets (omnivorous higher fat or higher carbohydrate, semi-vegetarian higher fat or higher carbohydrate) found that the semi-vegetarian higher fat group showed improved CAL and decreased gingival crevicular fluid volume after the follow-up period [ 155 ]. These studies indicate that lifestyle habits such as an appropriate low-calorie, vegetable-rich diet and moderate exercise can have a positive impact on periodontal tissue health.…”

Section: Next-generation Procedures In Periodontal Diseasementioning

confidence: 99%

Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Kikuchi

Hayashi

Mitani

2022

JPM

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Periodontal disease, a major cause of tooth loss, is an infectious disease caused by bacteria with the additional aspect of being a noncommunicable disease closely related to lifestyle. Tissue destruction based on chronic inflammation is influenced by host and environmental factors. The treatment of periodontal disease varies according to the condition of each individual patient. Although guidelines provide standardized treatment, optimization is difficult because of the wide range of treatment options and variations in the ideas and skills of the treating practitioner. The new medical concepts of “precision medicine” and “personalized medicine” can provide more predictive treatment than conventional methods by stratifying patients in detail and prescribing treatment methods accordingly. This requires a new diagnostic system that integrates information on individual patient backgrounds (biomarkers, genetics, environment, and lifestyle) with conventional medical examination information. Currently, various biomarkers and other new examination indices are being investigated, and studies on periodontal disease-related genes and the complexity of oral bacteria are underway. This review discusses the possibilities and future challenges of precision periodontics and describes the new generation of laboratory methods and advanced periodontal disease treatment approaches as the basis for this new field.

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A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health

Cited by 12 publications

References 53 publications

Protein Intake and Oral Health in Older Adults—A Narrative Review

Protein Intake and Oral Health in Older Adults—A Narrative Review

Abnormal Micronutrient Intake Is Associated with the Risk of Periodontitis: A Dose–response Association Study Based on NHANES 2009–2014

Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

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