Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Kikuchi, Takeshi; Hayashi, Jun-ichiro; Mitani, Akio

doi:10.3390/jpm12101743

Cited by 7 publications

(2 citation statements)

References 187 publications

(198 reference statements)

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“…Laser-generated light energy can interact with tissue in four distinct ways [ 57 , 58 ]. All four of these processes: reflection, transmission, scattering, and absorption, are possible.…”

Section: Light-sources In Dentistry Lasersmentioning

confidence: 99%

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

Luchian

Budală

Baciu

et al. 2023

IJMS

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Light is an emerging treatment approach that is being used to treat many diseases and conditions such as pain, inflammation, and wound healing. The light used in dental therapy generally lies in visible and invisible spectral regions. Despite many positive results in the treatment of different conditions, this therapy still faces some skepticism, which has prevented its widespread adoption in clinics. The main reason for this skepticism is the lack of comprehensive information about the molecular, cellular, and tissular mechanisms of action, which underpin the positive effects of phototherapy. However, there is currently promising evidence in support of the use of light therapy across a spectrum of oral hard and soft tissues, as well as in a variety of important dental subspecialties, such as endodontics, periodontics, orthodontics, and maxillofacial surgery. The merging of diagnostic and therapeutic light procedures is also seen as a promising area for future expansion. In the next decade, several light technologies are foreseen as becoming integral parts of modern dentistry practice.

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“…Laser-generated light energy can interact with tissue in four distinct ways [ 57 , 58 ]. All four of these processes: reflection, transmission, scattering, and absorption, are possible.…”

Section: Light-sources In Dentistry Lasersmentioning

confidence: 99%

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

Luchian

Budală

Baciu

et al. 2023

IJMS

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“…From a clinical point of view, these alterations are translated into inflammatory lesions of the connective tissue around teeth or implants, with progressive bone loss and increased probing depths with an accelerating pattern [ 15 ]. The ongoing homeostasis between the bone resorption matrix and the new bone formation matrix is altered [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis

Baru

Ráduly

Bica

et al. 2023

CIMB

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In recent years, the role of microRNA (miRNA) in post-transcriptional gene regulation has advanced and supports strong evidence related to their important role in the regulation of a wide range of fundamental biological processes. Our study focuses on identifying specific alterations of miRNA patterns in periodontitis compared with healthy subjects. In the present study, we mapped the major miRNAs altered in patients with periodontitis (n = 3) compared with healthy subjects (n = 5), using microarray technology followed by a validation step by qRT-PCR and Ingenuity Pathways Analysis. Compared to healthy subjects, 159 differentially expressed miRNAs were identified among periodontitis patients, of which 89 were downregulated, and 70 were upregulated, considering a fold change of ±1.5 as the cut-off value and p ≤ 0.05. Key angiogenic miRNAs (miR-191-3p, miR-221-3p, miR-224-5p, miR-1228-3p) were further validated on a separate cohort of patients with periodontitis versus healthy controls by qRT-PCR, confirming the microarray data. Our findings indicate a periodontitis-specific miRNA expression pattern representing an essential issue for testing new potential diagnostic or prognostic biomarkers for periodontal disease. The identified miRNA profile in periodontal gingival tissue was linked to angiogenesis, with an important molecular mechanism that orchestrates cell fate.

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Recent advances in nanomaterial-based biosensor for periodontitis detection

Hooshiar,

Moghaddam,

Kiarashi

et al. 2024

J Biol Eng

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Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as the alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose and eventually falling out. Timely identification has a crucial role in preventing and controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is a hunt for alternative diagnostic and monitoring methods due to the progress of technology. Various biomarkers have been assessed using multiple bodily fluids as sample sources. Furthermore, conventional periodontal categorization factors do not provide significant insights into the present disease activity, severity and amount of tissue damage, future development, and responsiveness to treatment. In recent times, there has been a growing utilization of nanoparticle (NP)-based detection strategies to create quick and efficient detection assays. Every single one of these platforms leverages the distinct characteristics of NPs to identify periodontitis. Plasmonic NPs include metal NPs, quantum dots (QDs), carbon base NPs, and nanozymes, exceptionally potent light absorbers and scatterers. These find application in labeling, surface-enhanced spectroscopy, and color-changing sensors. Fluorescent NPs function as photostable and sensitive instruments capable of labeling various biological targets. This article presents a comprehensive summary of the latest developments in the effective utilization of various NPs to detect periodontitis. Graphical Abstract

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Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Cited by 7 publications

References 187 publications

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

The Involvement of Photobiology in Contemporary Dentistry—A Narrative Review

Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis

Recent advances in nanomaterial-based biosensor for periodontitis detection

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