A Randomized, Clinical Trial Comparing Oral Celecoxib 200 mg, Celecoxib 400 mg, and Ibuprofen 600 mg for Acute Pain

Abstract

No significant difference exists among emergency department (ED) patients treated for acute pain, at five hours, with celecoxib 200 mg, celecoxib 400 mg, or ibuprofen 600 mg, though the power of the study to detect a change was low, 36%. However, the magnitude of pain relief for celecoxib, coupled with the cost of the medication, questions its use in the immediate ED setting.

Single dose oral celecoxib for acute postoperative pain in adults

“…Two studies (Malmstrom 1999; Gimbel 2001) were in the first review. We excluded two studies after reading the full paper (Salo 2003; White 2007). One study (Shirota 2001) is in Chinese and has not been translated.…”

Efficacy and Safety of Combination of NSAIDs and Muscle Relaxants in the Management of Acute Low Back Pain

“…Ibuprofen has been compared to celecoxib, codeine, and acetaminophen for pain relief. In a randomized controlled double-blind study in patients with acute pain ( n = 105), no significant differences in pain intensity were reported with celecoxib 200 mg and 400 mg and ibuprofen 600 mg. Change in VAS at 5 h was − 23.9 mm in the ibuprofen group, and -16.2 mm, and − 12.5 mm in celecoxib 200 mg and 400 mg groups, respectively [24]. In another study, patients with musculoskeletal pain had a greater improvement in pain score in the ibuprofen group (− 24 mm) than those in codeine (− 11 mm) and acetaminophen groups (− 12 mm) at 60 min [25].…”