Single dose oral celecoxib for acute postoperative pain in adults

Abstract

Single-dose oral celecoxib is an effective analgesic for postoperative pain relief. Indirect comparison suggests that the 400 mg dose has similar efficacy to ibuprofen 400 mg.

Comparison of Different Loading Dose of Celecoxib on Postoperative Anti-inflammation and Analgesia in Patients Undergoing Endoscopic Nasal Surgery—200 mg Is Equivalent to 400 mg

“…The inability to detect an analgesic efficacy between two different loading doses of celecoxib might be due to the moderate observed postoperative pain in this study rather than the severe pain noted in the Cochrane database [12] and a previous study [11]. This previous study comparing the two loading doses of celecoxib could not detect the difference for pain rescue consumption and patients' satisfaction with pain management either [11].…”

Analgesic efficacy of celecoxib in patients after oral surgery: special reference to time to onset of analgesia and duration of analgesic effect

“…Not much difference has been observed between the Tmax of celecoxib 200 mg group and 400 mg group [16]. However, there is a report that the time to onset of analgesia is significantly shorter in the celecoxib 400 mg group than in the 200 mg group and that the analgesic effect lasts longer [15,17]. Therefore, it is considered appropriate to set the dose for initial administration of celecoxib at 400 mg for postoperative pain after oral surgery.…”

The effect of pregabalin and celecoxib on the analgesic requirements after laparoscopic cholecystectomy: a randomized controlled trial

“…Celecoxib is a tricyclic compound having a pyrazole ring that exhibits an excellent level of anti-inflammatory action against COX-2 enzymes [17,18]. Celecoxib has also been widely investigated in perioperative and periprocedural settings [17,[19][20][21][22].…”

“…Celecoxib has also been widely investigated in perioperative and periprocedural settings [17,[19][20][21][22]. Opioid-sparing effects of COX-2 inhibitors have been demonstrated in laparoscopic cholecystectomy [23].…”