No significant difference exists among emergency department (ED) patients treated for acute pain, at five hours, with celecoxib 200 mg, celecoxib 400 mg, or ibuprofen 600 mg, though the power of the study to detect a change was low, 36%. However, the magnitude of pain relief for celecoxib, coupled with the cost of the medication, questions its use in the immediate ED setting.
The impermeability of the blood-aqueous barrier to certain antibiotics precludes their use in intraocular infections, and it is very difficult to identify the causative organism if laboratory facilities are not available.With
Material and methodsPatients Those with hypopyon corneal ulceration, for whom there was apparently no chance of retaining eye or vision, were selected for this study, and it was explained to them that the sight could not be restored in any case although it might be possible to save the eye.Anaesthesia i per cent. Anaethain drops were instilled three times every 5 minutes so as to cause surface anaesthesia, and the cornea was incised with a sharp cataract knife at 2 or I0 o'clock inside the limbus. This upper portion was selected to ensure that the drug remained as long as possible in the anterior chamber, by avoiding leakage due to gravity.Surgery Almost all the aqueous was drained out by depressing the posterior lip with an iris repositor. o03 ml. Soframycin was injected into the anterior chamber with a 2 ml. syringe and fine needle.Postoperative care Atropine drops (i per cent.) and Soframycin ointment were applied and the eye was bandaged. No systemic antibiotics were given, but analgesics were given whenever needed. Cleansing, hot fomentations, and atropine and Soframycin eye drops were applied locally. In cases in which a
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